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Treatment of Localized Vitiligo with 1% Pimecrolimus Cream versus 0.05% Clobetasol Propionate Cream—Single, Blinded, Comparative Therapeutic Trial

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第2期5卷 107-115页

作者： Khalifa E. Sharquie Hayder R. Al-Hamamy Adil A. Noaimi Kholod A. Ali Scientific Council of Dermatology and Venereologyl Iraqi and Arab Board for Medical Specializations Department of Dermatology Collage of Medicine University of Baghdad Baghdad Iraq Scientific Council of Dermatology and Venereology Iraqi Board for Medical specializations Baghdad Teaching Hospital Medical City Baghdad Iraq Department of Dermatology & Venereology Baghdad Teaching Hospital Baghdad Iraq

Background: Calcineurin inhibitors like tacrolimus and pimecrolimus are new modality of treatment of localized vitiligo. Objective: To compare the effectiveness and side effects of 1% pimecrolimus cream in comparison with 0.05% clobetasol propionate cream as a treatment of localized type of vitiligo. Patients and Methods: Fifty two patients with localized vitiligo were included in this single, blind, comparative therapeutic trial. Full history and examination for each patient was done. Wood’s light was used when needed to confirm the diagnosis. Thirty (57.7%) were females and 22 (42.3%) males, female to male ratio of 1.36:1. Their ages ranged between 3 - 40 (13.15 ± 7.9) years, while disease duration ranged from 6 - 84 (29.62 ± 20.56) months. Total numbers of lesions were 114 lesions with a mean of 2.2 lesions per patient. The surface area of the lesions ranged between 1 - 31 (7.15 ± 6.98) cm2. Vitiliginous patches were most commonly located on face 48 (42.1%) lesions, and lower limbs 35 (30.7%) lesions. Patients were divided in to two groups according to the type of therapeutic modality.?Group?A?consisted of 25 patients (52 lesions) receiving 1% pimecrolimus cream and?Group?B?27 patients (62 lesions) treated with 0.05% clobetasol propionate cream, both used twice daily. The amount of cream per area was applied according to rule of fingertip unit. Measuring the surface area of the lesions and calculating the reduction rate were done every month till the end of the 6th?month. Then patients were asked to stop the use of medication to be re-evaluated again after 3 months without any treatment and to record any local or systemic side effects. Results: After 6 months of treatment there was 79.67% reduction in the surface area of lesions in?Group?A, while inGroup?B?there was 82.59% reduction in the surface area with no statistically significant difference between the two groups. The reduction rate was early as there was statistically significant reduction for both groups

关键词： Localized Vitiligo pimecrolimius Clobetasol Propionate

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