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Hand self-Shiatsu for sleep problems in p ersons with chronic pain: a pilot study

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Journal of Integrative Medicine 2014年第2期12卷 94-101页

作者： Cary A.Brown Geoff Bostick Leisa Bellmore Dilesha Kumanayaka Department of Occupational Therapy Faculty of Rehabilitation MedicineUniversity of Alberta Department of Physical Therapy Faculty of Rehabilitation MedicineUniversity of Alberta Shiatsu Therapist Artists’ Health CentreToronto Western Hospital

OBJECTIVE： Difficulty falling asleep （sleep latency） and staying asleep （sleep maintenance） are common problems for persons living with pain. Research demonstrates that sleep problems are, in turn, related to exacerbation of chronic pain. There is a growing body of evidence for a range of pragmatic, non-pharmacological sleep interventions that can potentially be incorporated into pain management programs. This study looks at the outcome of teaching patients with musculoskeletal pain standardized pre-bedtime hand self-Shiatsu （HSS） to reduce sleep latency. METHODS： A case series design, with participants acting as their own controls, was selected to facilitate hypothesis generation for this novel, under-researched intervention. Sleep efficiency, latency and maintenance, sleep beliefs, pain intensity and basic participant demographics were collected at baseline with actigraphy and standardized self-report questionnaires. After one week of baseline data collection, the HSS intervention was taught to participants. Follow-up data were collected at 2 and 8 weeks post-intervention. RESULTS： Data collected at baseline and the two follow-up periods revealed no apparent changes in the objective actigraphy data. However a trend toward improved self-reported sleep latency （time to fall asleep） and sleep duration （time spent asleep） emerged. A number of participants reported they were more concerned with increasing their period of unbroken sleep as opposed to their total sleep time and it is possible that HSS may be useful to be applied during nighttime awakenings as well as before bed. None of the participants reported adverse effects of the intervention. CONCLUSION： These preliminary findings are promising and future studies exploring the mechanism of action and with stronger control of treatment fidelity are indicated.

关键词： Shiatsu self-management pain sleep insomnia pilot study

Effect of a novel dietary supplement on pH levels of healthy volunteers:a pilot study

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Journal of Integrative Medicine 2013年第6期11卷 384-388页

作者： Stephen Douglas Anton Xiaomin Lu Ginny Bank Kacey Heekin Debbie Saha Pamela J.Dubyak Heather Ann Hausenblas Department of Aging and Geriatric Research University of Florida Department of Clinical and Health Psychology University of Florida Department of Biostatistics University of Florida RFI Ingredients Department of Sport and Exercise Sciences University of Florida Department of Sport and Exercise Sciences Jacksonville University

OBJECTIVE： To examine the effects of a greens alkalizing dietary supplement on urinary pH levels in individuals with lower-than-average pH levels. METHODS： The present study investigated the effects of an alkalizing formula （Reserveage Wholeganic GreensTM） on four individuals who had average urinary pH levels below 6.0 for three consecutive days. Following the three-day, baseline period, participants received Reserveage Wholeganic GreensTM for four consecutive days and were instructed to continue to measure their urine pH levels. Paired samples t-tests were used to examine pH levels before and after a four-day treatment period with Reserveage Wholeganic GreensTM. RESULTS： Compared to baseline, mean urine pH levels in all volunteers were significantly higher following the supplementation with Reserveage Wholeganic GreensTM （5.89 ±0.20 vs 5.56 ± 0.23; P〈0.01）. Participants＇ pH levels were also significantly higher than baseline on days 5, 6, and 7 of the treatment period （P 〈 0.05）. Noteworthy, on day 7, participants＇ mean pH levels were significantly higher than at the beginning of the treatment period （6.03 ± 0.15 at day 7 vs 5.65 ± 0.24 at day 4; P 〈 0.01）. CONCLUSION： The findings of this study suggest that supplementation with Reserveage Wholeganic GreensTM has an alkalizing effect on the body and can increase the urine pH levels in individuals with lower-than-average pH levels.

关键词： dietary supplements urinalysis acidosis pilot study

A pilot study about the First Cases of Coronary Angioplasty in Democratic Republic of Congo/Kinshasa: Patient Profile

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Case Reports in Clinical Medicine 2023年第10期12卷 371-388页

作者： David Ipungu Gondele Eulethère Vita Kintoki Yves Lubenga Georges Ngoyi Trésor Mvunzi Dominique Mupepe Nathan Buila Zéphirin Kamuanga Fahd Qureshi Aliosha Nkodila Jean Robert Rissasi Makulo Jean René M’buyamba-Kabangu Cardiology Unit University of Kinshasa Hospital Kinshasa The Democratic Republic of Congo Cardiology Unit Centre Hospitalier Victor Dupouy Argenteuil France Cardiology Unit H.J. Hospitals Kinshasa The Democratic Republic of Congo Public Health and Familly Medecine Protestant University of Congo Kinshasa The Democratic Republic of Congo Nephrology Unit University of Kinshasa Hospital Kinshasa The Democratic Republic of Congo

Background: The objective of this pilot study was to describe clinical profile, electric, echocardiographic and angiographic caracteristics with procedural outcome of congolease patients undergoing coronarography in the first and only one cardiac catheterization center opened in Kinshasa. Methods: An analytical cross-sectional study was carried out over a period from October 2019 (date of establishment of the first coronary angiography unit in DR Congo) to March 2021. We proceeded to a serial sampling of the consecutive cases of all the patients who have an angiographic exploration of coronary arteries. Clinical, ECG and cardiac ultrasound data were collected in all patients. The indications for the coronary angiography examination were set by differents cardiologists on the basis of repolarization troubles in the electrocardiogram, cinetic troubles in echocardiography, positive stress test and chest pain in patients with cardiovascular risq factors. Results: The serie (47 patients) was predominantly male with a sex ratio M/W of 2.6. The average age was 59.8 ± 10.5 years. Arterial hypertension (HBP) was the main risk factor (89.4%);followed by diabetes mellitus (14.9%). Chest pain was the main functional sign with an atypical character in 44.7%. The ECG showed ST segment depression (17%) and T wave inversion (17%), the anterior region being the most affected. Hypokinesia was the most common echocardiographic abnormality (34%), followed by akinesia (10.6%). The anteroseptal and apical territories were affected in 12.8%. Dilated myocardiopathy (DMC) was significantly predominant in the male sex (29.4% vs 7.7%;p = 0.011). With radial puncture as the main approach, coronary angiography was pathological in 44% revealing mono-truncal lesions. The left coronary network was the most affected: the middle inter ventricular artery (12.8%), the proximal interventricular artery (10.6%) and the proximal circonflex artery (10.6%). In multivariate logistic regression analysis, age

关键词： Heart Disease Coronary Angioplasty Patient Profile pilot study Democratic Republic of Congo

Results and analysis:a pilot study on quality of life of soldiers in the first response army

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Journal of Medical Colleges of PLA(China) 2006年第6期21卷 388-392页

作者：汤明新郭强阎小妍郭鹏飞 Department of Health Administration Faculty of Health Services Second Military Medical University Training Department Second Military Medical University Department of Health Statistics Faculty of Health Services Second Military Medical University

Objective： To explore the fundamental theory, methods and data of the quality of life （QOL） of soldiers and its influence factors in the first response army. Methods： Totally 215 soldiers in the first response army of a military area in China were inquired by using self-regulating questionnaire and WHOQOL-BREF （Chinese Edition）. Resalts： WHOQOL-BREF had good acceptability, reliability and validity in the first response army. QOL of soldiers in the first response army was middling. The influencing factors of QOL of the soldiers in first army includes self-report health, different areas where the army men come from, different arms of services, whether only child in family. And the difference was statistically significant. Conclusion： WHOQOL-BREF is fit for evaluating the quality of life of soldiers in the first response army. There are differences of the quality of life among the soldiers in the first response army. So we should take appropriate measures to improve the soldiers＇ quality of life.

关键词： first response army quality of life pilot study WHOQOL-BREF

Intravenous thrombolytic therapy for acute ischemic stroke (A pilot study in China)

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中国临床神经科学 2000年第Z1期8卷 16-页

作者： Qingtang CHEN, MD First Hospital of Beijing Medical University Beijing 100034 CHINA

Object: To introduce our experience of therapy with T-PA in cerebral infarction in China, contraposed to a French document with a series of 100 cases. Methods: Inclusion criteria were same with Trouillas' protocol. Location attached was limited within the territory of internal carotid artery (ICA). The dose of rT-PA was 0.8-0.85mg/Kg. An initial bolus of 10% of the total dose was infused before 90% of the total dose was dropped byvein over 90 minutes. Calcic Nadroparin was continued after 12 hours ofthrombolysis for 10 days. At same time, 20% of Marnitol was administed according to the disorder state. The Scandinavia Stroke Score (SSS) were utilized to evaluate to the neurological function impaired before and after treatment for 24 hours, one week, one month and 3 months and modified Rankin′s Score (mRS) to the capability of life when 90 days after the ***: (1) Total 16 cases, who come from Shanghai of China, 8 cases of male and 8 cases of female, with 68.44±7.63 years old, were observed. The mean interval is 278.44±73.73 minutes. There are no significant different for baseline SSS, SSS at day 1, Day 7, Day 30 and Day 90 between our data and the data published. (P ＞0.05) In our group, there are 5 cases (31.25%) with absolute recovery, 4 cases (25%) with remarkable sequels, 2 cases with incapability himself because obvious sequels and 5 cases died in this group. Our study result is no difference with the document observed on Lyon of French. (P ＞0.05 ) (2) There are 10 cases of baseline SSS＜20. In this subgroup, the prognosis is significant difference with 6 cases of subgroup of baseline SSS ＞20. (P ＜0.05) The worse the SSS of baseline was, the worse prognosis is. No evidence of hemorrhage in the CT scans. It is important causes that result in bad prognosis: serious heart failure and cerebral infarction with great territory. (3) There are 5 cases died in our group. Among them, 60% died within 72 hours and 2 cases died at 4th day. The area of cerebral inf

关键词： ischemic stroke thrombolytic therapy cerebral hemorrhage time window clinical trial blood pressure pilot study low density neurological deficit low molecular weight cerebral infarctions clinical features mortality rate CT scan

Biodegradable stent or balloon dilatation for benign oesophageal stricture: pilot randomised controlled trial

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World Journal of Gastroenterology 2014年第48期20卷 18199-18206页

作者： Anjan Dhar Helen Close Yirupaiahgari K Viswanath Colin J Rees Helen C Hancock A Deepak Dwarakanath Rebecca H Maier Douglas Wilson James M Mason Department of Gastroenterology County Durhamand Darlington NHS Foundation Trust Co. Durham DL14 6ADUnited Kingdom Durham Clinical Trials Unit School of Medicine Pharmacy and Health Durham University Queen’s Campus Wolfson Research Institute University Boulevard Stockton-on-Tees TS17 6BH United Kingdom Department of Surgery James Cook University Hospital Marton Road Middlesbrough TS4 3BW United Kingdom Department of Gastroenterology South Tyneside Hospitals NHS Foundation Trust Harton Lane South Shields NE34 0PL United Kingdom Department of Gastroenterology University Hospitals of North Tees Hardwick Stockton on Tees TS19 8PE United Kingdom

AIM: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures.

关键词： Benign oesophageal stricture Biodegradable stent Endoscopic balloon dilatation pilot study Randomised controlled trial Dysphagia

A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis: a pilot trial

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Journal of Integrative Medicine 2013年第1期11卷 17-25页

作者： Martin Schencking Stefan Wilm Marcus Redaelli Institute for General Practice and Family Medicine University Witten/Herdecke58448 Witten Germany

BACKGROUND： An increasingly aging population implies an increasing prevalence of osteoarthritis （OA） of hip or knee. It has been ascertained that unspecific hydrotherapy of OA according to Sebastian Kneipp not only improves the range of mobility but also reduces pain significantly and increases the quality of life of the patients affected. OBJECTIVE： The main aim of this pilot study was to determine the effects of hydrotherapy in comparison to conventional physiotherapy, and to analyze the feasibility of the study design under clinical circumstances. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： The study design is a prospective randomized controlled three-arm clinical pilot trial, carried out at a specialist clinic for integrative medicine. Thirty patients diagnosed with symptomatic OA of hip or knee and radiologic findings were randomly assigned to one of two intervention groups and a control group： hydrotherapy （group 1）, physiotherapy （group 2）, and both physiotherapy and hydrotherapy （group 3, control group） of the affected joint. MAIN OUTCOME MEASURES： Primary outcome： pain intensity of the affected joint in the course of inpatient treatment; secondary outcome： health-related quality of life, joint-specific pain and mobility in the course of the study. RESULTS： Concerning the main outcome, intervention group 1 showed most beneficial effects in the course of inpatient treatment, followed by groups 3 and 2, and also the indirect flexion ability of hip or knee together with the general patient mobility through the ＂timed up and go＂ test were mainly improved within group 1 followed by groups 3 and 2. CONCLUSION： The results of this pilot study demonstrate beneficial effects of hydrotherapy. The study design is feasible. For statistically significant evidence and a robust conclusion of efficacy of Kneipp＇s hydrotherapy, a larger sample size is necessary. TRIAL REGISTRATION NUMBER： NCT 00950326.

关键词： hydrotherapy physical therapy osteoarthritis pain measurement pilot study

Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome

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Neural Regeneration Research 2015年第11期10卷 1856-1859页

作者： Michael Alexander Malahias Elizabeth O.Johnson George C.Babis Vasileios S.Nikolaou Second Department of Orthopedics Athens University Department of Anatomy School of Medicine Athens University

Both in vitro and in vivo experiments have confirmed that platelet-rich plasma has therapeutic effects on many neuropathies, but its effects on carpal tunnel syndrome remain poorly understood. We aimed to investigate whether single injection of platelet-rich plasma can improve the clinical symptoms of carpal tunnel syndrome. Fourteen patients presenting with median nerve injury who had suffered from mild carpal tunnel syndrome for over 3 months were included in this study. Under ultrasound guidance, 1-2 m L of platelet-rich plasma was injected into the region around the median nerve at the proximal edge of the carpal tunnel. At 1 month after single injection of platelet-rich plasma, Visual Analogue Scale results showed that pain almost disappeared in eight patients and it was obviously alleviated in three patients. Simultaneously, the disabilities of the arm, shoulder and hand questionnaire showed that upper limb function was obviously improved. In addition, no ultrasonographic manifestation of the carpal tunnel syndrome was found in five patients during ultrasonographic measurement of the width of the median nerve. During 3-month follow-up, the pain was not greatly alleviated in three patients. These findings show very encouraging mid-term outcomes regarding use of platelet-rich plasma for the treatment of carpal tunnel syndrome.

关键词： nerve regeneration carpal tunnel syndrome platelet-rich plasma ultrasound guidance pilot study neural regeneration

pilot Trial on the Efficacy and Safety of a Natural Mineral Water Rich in Hydrogen Carbonate on Functional Dyspepsia and Heartburn

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Open Journal of Gastroenterology 2016年第3期6卷 88-96页

作者： Ute Pohl Annegret Auinger Gordana Bothe Ralf Uebelhack Analyze & realize GmbH Berlin Germany

Background: Dyspepsia and heartburn are among the most frequent complaints of the upper gastrointestinal tract impacting quality of life. The present study aimed to investigate the impact of drinking a natural mineral water (medicinal product category “Heilwasser” in Germany) high in hydrogen carbonate (Staatl. Fachingen STILL) on functional dyspeptic complaints and heartburn. Methods: 56 men and women with self-reported heartburn were enrolled to this one-arm pilot study. They had to drink 1.5 L of a hydrogen carbonate rich mineral water each day over a course of six weeks. Participants reported the number and duration of heartburn episodes in a daily dairy. The Reflux Disease Questionnaire (RDQ), Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) and the Gastrointestinal Quality of Life Index (GILQI) were used to assess the therapeutic course of the treatment and the Short Form Health Survey (SF-12) to assess general quality of life. Mean ± standard deviation were calculated and pre- and post-treatment changes were compared using the Wilcoxon test. Results: The consumption of a hydrogen carbonate rich mineral water decreased the number of heartburn episodes per week significantly by 4.8 ± 8.2 at the end of the study (p pilot study provides evidence that supplementation with natural mineral water rich in hydr

关键词： Heartburn Dyspepsia Natural Mineral Water “Heilwasser” pilot study Hydrogen Carbonate