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phytic acid-modified CeO_(2) as Ca^(2+) inhibitor for a security reversal of tumor drug resistance

Nano Research 2022年第5期15卷 4334-4343页

作者： Zhimin Tian Junlong Zhao Shoujie Zhao Huicheng Li Zhixiong Guo Zechen Liang Jiayuan Li Yongquan Qu Dongfeng Chen Lei Liu Department Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Cancer Biology Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China The State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400042China

Ca^(2+)plays critical roles in the development of diseases,whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and *** solve this issue,with the help of Ca overexpressed tumor drug resistance model,the phytic acid(PA)-modified CeO_(2) nano-inhibitors have been rationally designed as an unprecedentedly safe and efficient Ca2+inhibitor to successfully reverse tumor drug resistance through Ca^(2+)negative regulation *** doxorubicin(Dox)as a model chemotherapeutic drug,the Ca^(2+)nano-inhibitors efficiently deprived intracellular excessive free Ca2+,suppressed P-glycoprotein(P-gp)expression and significantly enhanced intracellular drug accumulation in Dox-resistant tumor *** Ca^(2+)negative regulation strategy improved the intratumoral Dox concentration by a factor of 12.4 and nearly eradicated tumors without obvious adverse ***,nanocerias as pH-regulated nanozyme greatly alleviated the adverse effects of chemotherapeutic drug on normal cells/organs and substantially improved survivals of *** anticipate that this safe and effective Ca^(2+)negative regulation strategy has potentials to conquer the pitfalls of traditional Ca inhibitors,improve therapeutic efficacy of common chemotherapeutic drugs and serves as a facile and effective treatment platform of other Ca^(2+) associated diseases.

关键词： Ca^(2+)nano-inhibitor nanoceria tumor drug resistance phytic acid nanozyme

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phytic acid-assisted hybrid engineering of MOF-derived composites for tunable electromagnetic wave absorption

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Journal of Materials Science & Technology 2024年第19期186卷 164-173页

作者： Xiang Zhang Kai Yao Xiao Wang Jinli Wang Hongtao Guo Xiaona Ma Yang Yang Hongjing Wu Wei Lu Shanghai Key Lab.of D&A for Metal-Functional Materials School of Materials Science&EngineeringTongji UniversityShanghai 201804China School of Science Northwestern Polytechnical UniversityXi’an 710072China

Hybrid engineering is gradually deemed as a powerful approach to solving the bottleneck problem of metal-organic framework (MOF) derived absorbers for practical application. Herein, a new type of semiconductor/carbon-based hybrid material was successfully prepared by phytic acid (PA) modification and carbonization of MOF/bacterial cellulose (BC) precursors, which remedied the drawbacks of structural instability, lethal byproducts and complicated steps reported previously. Specifically, the obtained Fe(PO3)2@C/phosphorus-doped carbon foam (Fe(PO3)2@C/PCF) had a 3D hybrid micro-nanostructure that integrated spatial microcurrent network, multi-level pores, heterogeneous interfaces and lattice defects, showing its unique advantages of low filler content (15 wt.%), moderate surface reflectivity, multi-band microwave absorption and radar stealth. The experimental analysis and CST simulation further revealed that PA dosage can precisely adjust the hybrid phase content, pore texture and electromagnetic parameters of the final product to achieve synergistic enhancement of multiple dielectric response, impedance matching and attenuation capacity. As a result, an effective bandwidth (EAB) of 6 GHz and a minimum reflection loss (RLmin) of -57.0 dB were obtained in the Ku- and C-bands, respectively. These encouraging results may advance the development of novel MOF-derived absorbents based on the hybridization principle.

关键词： Hybrid engineering MOF derivatives phytic acid Microwave absorption

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phytic acid-derived fabrication of ultra-small MoP nanoparticles for efficient CO methanation: Effects of P/Mo ratios

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Journal of Energy Chemistry 2020年第8期29卷 248-255,I0009页

作者： Jun Zhao Zijia Yin Baowei Wang Zhenhua Li Yan Xu Xinbin Ma Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Molybdenum phosphide(MoP) catalyst has been widely applied in hydrogenation reactions, while the preparation of unsupported MoP catalysts with ultra-small size and large specific surface area(SBET) is still challenging. Herein, we have provided a facile method for preparing a series of MoP-x(x=P/Mo ratios ranging from 1 to 5) catalysts by pyrolyzing phytic acid(PA)-derived Mo complexes in a H2 atmosphere. The physicochemical properties and the catalytic activity of MoP catalysts were investigated. The results showed that the obtained MoP-5 catalyst had the largest SBETand exhibited ultra-small nanoparticle diameter of 3.6 nm, which ascribed to the chelation of PA and the confinement of deposited *** the content of PA increased, the synthetic mechanism of MoP was also affected, which led to the difference in the valence of surface Mo species. The characterization results further confirmed that Moδ+ sites in MoP catalysts are active sites for methanation reaction and its content on the surface of MoP-x catalysts determines the catalytic activity.

关键词： Molybdenum phosphide phytic acid P/Mo ratios Ultra-small nanoparticle CO methanation

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phytic acid Contents of Wheat Flours from Different Mill Streams

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Agricultural Sciences in China 2010年第11期9卷 1684-1688页

作者： WU Peng ZHAO Tao TIAN Ji-chun State Key Laboratory of Crop Biology Shandong Agricultural University Tai ＇an 271018 P.R.China College of Food Science and Engineering Shandong Agricultural University Tai＇an 271018 P.R.China College of Horticulture Science and Engineering Shandong Agricultural University Tai ＇an 271018 P.R. China

The phytic acid contents of eight fractions of wheat flours from different mill streams and those in wheat brans, which were separated by different sieves into various sizes, were determined and analyzed. A rapid method for phytic acid assay by adding thioglycolic acid （mercapto acetic acid） with 2,2-bipyridine was used, with an acidic iron-Ⅲ-solution of known iron content. The amount ofphytate was indicated by the decrease in iron in the supernatant. Significant differences were observed in phytic acid content among different milling streams and different cultivars （P〈0.05）. On an average, coarse bran had the highest phytic acid content （53.85 mg g^-1）, and the shorts had 28.48 mg g^-1. The B5 break flour had a higher phytic acid content （4.8 mg g^-1） than the B7 （2.75 mg g^-1） and B8 （2.03 mg g^-1） reduction flours. Lower values were found in the B3, B6 and B7 flours （1.07, 0.79, and 0.76 mg g^-1, respectively）. The phytic acid contents of bran decreased with smaller bran sizes, ranging from 54 to 5.09 mg g^-1.

关键词： phytic acid wheat mill streams bran flour

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Effect of Post Heat Treatment on Corrosion Resistance of phytic acid Conversion Coated Magnesium

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Journal of Materials Science & Technology 2013年第2期29卷 180-186页

作者： R.K. Gupta K. Mensah-Darkwa D. Kumar Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB) Department of Mechanical Engineering North Carolina A&T State University 1601 East Market Street Greensboro NC 27411 USA

An environment friendly chemical conversion coating for magnesium was obtained by using a phytic acid solution. The effect of post-coating 1heat treatment on the microstructures and corrosion properties of phytic acid conversion coated magnesium was investigated. It was observed that the microstructure and corrosion resistive properties were improved for the heat treated samples. The corrosion current density for bare magnesium, phytic acid conversion coated magnesium, and post-coating heat treated magnesium was calculated to be 2.48 ×10^-5, 1.18×10^-6, and 9.27 × 10^7 A/cm^2, respectively. The lowest corrosion current density for the heat treated sample indicated its highest corrosion resistive effect for the magnesium. The maximum corrosion protective nature of the heat treated sample was further confirmed by the largest value of impedance in electrochemical impedance spectroscopy studies.

关键词： Magnesium phytic acid Corrosion Impedance spectroscopy Scanning electron microscopy

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Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis

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Journal of Integrative Plant Biology 2024年第10期66卷 2109-2125页

作者： Yuying Ren Mengdan Jiang Jian-Kang Zhu Wenkun Zhou Chunzhao Zhao Key Laboratory of Plant Design National Key Laboratory of Plant Molecular GeneticsShanghai Center for Plant Stress BiologyCAS Center for Excellence in Molecular Plant Sciencesthe Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100190China State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China Ministry of Agriculture and Rural Affairs Key Laboratory of Gene Editing Technologies Nanfan Research InstituteChinese Academy of Agricultural SciencesSanya 572024China

Generation of crops with low phytic acid(myoinositol-1,2,3,4,5,6-hexakisphosphate(InsP6))is an important breeding direction,but such plants often display less desirable agronomic *** this study,through ethyl methanesulfonate-mediated mutagenesis,we found that inositol 1,3,4-trisphosphate5/6-kinase 4(ITPK4),which is essential for producing InsP6,is a critical regulator of salt tolerance in *** of function of ITPK4 gene leads to reduced root elongation under salt stress,which is primarily because of decreased root meristem length and reduced meristematic cell *** itpk4 mutation also results in increased root hair density and increased accumulation of reactive oxygen species during salt *** sequencing assay reveals that several auxin-responsive genes are down-regulated in the itpk4-1 mutant compared to the ***,the itpk4-1 mutant exhibits a reduced auxin level in the root tip and displays compromised gravity response,indicating that ITPK4 is involved in the regulation of the auxin signaling *** suppressor screening,it was found that mutation of Multidrug Resistance Protein 5(MRP5)5 gene,which encodes an ATP-binding cassette(ABC)transporter required for transporting InsP6from the cytoplasm into the vacuole,fully rescues the salt hypersensitivity of the itpk4-1 mutant,but in the itpk4-1 mrp5 double mutant,InsP6remains at a very low *** results imply that InsP6homeostasis rather than its overall amount is beneficial for stress tolerance in ***,this study uncovers a pair of gene mutations that confer low InsP6content without impacting stress tolerance,which offers a new strategy for creating“low-phytate”crops.

关键词： ITPK4 MRP5 phytic acid root elongation salt stress

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RNAi-Mediated Silencing of ITPK Gene Reduces phytic acid Content,Alters Transcripts of phytic acid Biosynthetic Genes,and Modulates Mineral Distribution in Rice Seeds

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Rice science 2020年第4期27卷 315-328页

作者： Aritra KARMAKAR Sananda BHATTACHARYA Shinjini SENGUPTA Nusrat ALI Sailendra Nath SARKAR Karabi DATTA Swapan K.DATTA Laboratory of Translational Research on Transgenic Crops Department of BotanyUniversity of CalcuttaKolkata 700019West BengalIndia Plant Nutrition Department Centre Mondial de I’Innovation RoullierSaint Malo 35400France

phytic acid is the principal storage form of phosphorus in plant seeds and an essential signalling molecule in several regulatory processes of plant ***,it is known as an anti-nutrient compound owing to its potent chelating ***,reducing the phytic acid content in crops is *** involving regulation of MIPS and IPK1 genes to generate low phytate rice have been reported ***,the functional significance of OsITPK and the effect of its down-regulation on phytic acid content and the associated pleiotropic effects on rice have not yet been *** this study,tissue specific RNA interference(RNAi)-mediated down-regulation of a major ITPK homolog(OsITP5/6K-1)resulted in 46.2%decrease in phytic acid content of T2 transgenic seeds with a subsequent 3-fold enhancement in the inorganic phosphorus *** of OsITP5/6K-1 altered the transcript levels of essential phytic acid pathway genes,without significantly affecting the transcript levels of other OsITPK ***,the mapping of elements through X-ray microfluorescence analysis revealed significant changes in the spatial distribution pattern and translocation of elements in low phytate ***,low phytate polished seeds exhibited 1.3-fold and 1.6-fold enhancement in iron and zinc content in the grain endosperm,*** of OsITP5/6K-1 also altered the amino acid and myo-inositol content of the transgenic *** results successfully established that RNAi-mediated silencing of OsITP5/6K-1 gene significantly reduced the phytate levels in seeds without hampering the germination potential of seeds and plant *** present study provided an insight into the mechanism of phytic acid biosynthesis pathway.

关键词： inositol triphosphate kinase-1 phytic acid mineral content RNA interference silencing X-ray microfluorescence

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Identification of Quantitative Trait Loci for phytic acid Concentration in Maize Grain Under Two Nitrogen Conditions

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Journal of Integrative Agriculture 2013年第5期12卷 765-772页

作者： LIU Jian-chao HUANG Ya-qun MAWen-qi ZHOU Jin-feng BIAN Fen-ru CHEN Fan-jun MI Guo-hua Key Lab of Plant-Soil Interaction Ministry of Education/College of Resources and Environmental SciencesChina Agricultural University Key Lab of Biology and Genetic Improvement of Maize in Arid Area of Northwest Region Ministry of Agriculture/College of AgronomyNorthwest A&F University College of Agronomy Agricultural University of Hebei College of Resources and Environmental Sciences Agricultural University of Heibei

phytic acid （PA） is the main storage form of phosphorus （P） in seeds. It can form insoluble complexes with microelements, thereby reducing their bioavailability for animals. Identification of quantitative trait loci （QTLs） associated with grain PA concentration （PAC） is essential to improve this trait without affecting other aspects of grain nutrition such as protein content. Using a recombinant inbred line （RIL） population, we mapped QTL for grain PAC, as well as grain nitrogen concentration （NC） and P concentration （PC） in maize under two N conditions in 2 yr. We detected six QTLs for PAC. The QTL for PAC on chromosome 4 （phi072-umc 1276） was identified under both low-N and high-N treatments, and explained 13.2 and 15.4% of the phenotypic variance, respectively. We identified three QTLs for grain NC, none of which were in the same region as the QTLs for PAC. We identified two QTLs for PC in the low-N treatment, one of which （umc1710-umc2197） was in the same interval as the QTL for PAC under high-N conditions. These results suggested that grain PAC can be improved without affecting grain NC and inorganic PC.

关键词： maize nitrogen phosphorus phytic acid QTL

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Genome editing toward biofortified soybean with minimal trade-off between low phytic acid and yield

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aBIOTECH 2024年第2期5卷 196-201页

作者： Wenxin Lin Mengyan Bai Chunyan Peng Huaqin Kuang Fanjiang Kong Yuefeng Guan Sanya Institute of China Agricultural University Sanya 572000China College of Agronomy China Agricultural UniversityBeijing 100193China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Innovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China

phytic acid(PA)in grain seeds reduces the bioavailability of nutrient elements in monogastric animals,and an important objective for crop seed biofortification is to decrease the seed PA ***,we employed CRISPR/Cas9 to generate a PA mutant population targeting PA biosynthesis and transport genes,including two multi-drug-resistant protein 5(MRP5)and three inositol pentose-phosphate kinases(IPK1).We characterized a variety of lines containing mutations on multiple IPK and MRP5 *** seed PA was more significantly decreased in higher-order mutant lines with multiplex ***,such mutants also exhibited poor agronomic *** the population,we identified two lines carrying single mutations in ipk1b and ipk1c,*** mutants exhibited moderately reduced PA content,and regular agronomic performance compared to the wild *** study indicates that moderately decreasing PA by targeting single GmIPK1 genes,rather than multiplex mutagenesis toward ultra-low PA,is an optimal strategy for low-PA soybean with a minimal trade-off in yield performance.

关键词： Genome editing phytic acid Soybean Agronomic traits CRISPR/Cas9

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Raman Spectroscopy Detection of phytic acid in Plant Seeds Reveals the Absence of Inorganic Polyphosphate

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Molecular Plant 2015年第5期8卷 826-828页

作者： Bernadett Kolozsvari Steven Firth Adolfo Saiardi Department of Chemistry University College London London WC1H 0AJ UK

Dear Editor The fully phosphorylated myo-inositol ring, inositol hexakisphos- phate （IP6） is commonly known as phytic acid. It is the most abundant form of organic phosphate in soil （Raboy, 2003）. phytic acid is able to regulate a broad range of intracellular processes, controlling many aspects of cell physiology both directly or as its derivative inositol pyrophosphates （Wilson et al., 2013）. One such process is phosphate homeostasis, as IP6 regulates the level of inorganic polyphosphate （polyP）, a linear polymer of phosphate groups that buffers cellular phosphate by regulation of its synthesis/degradation （Saiardi, 2012）. The quantification of seed phosphate levels, and the identification and localization of phosphate-containing molecular species, is of fundamental importance for the biotechnology industry. Several studies have reported the biochemical extrac- tion and analysis of the levels of phytic acid in plant seeds （Thavarajah and Thavarajah, 2014）. Direct experimental tools to visualize the phytic acid cellular distribution have not yet been developed, although DAPI fluorescence shift has been used to visualize the cellular presence of polyP.

关键词： RAMAN spectroscopy phytic acid

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