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Benefit in physical function and quality of life to nonsurgical treatment of varicose veins: Pilot study

World Journal of Clinical Cases 2024年第3期12卷 517-524页

作者： Gwon-Min Kim BoKun Kim Minwoo Jang Jong-Hwan Park Miju Bae Chung Won Lee Jong Won Kim Up Huh Medical Research Institute Pusan National University School of MedicineYangsan 50612South Korea Future Convergence Research Institute Changwon National UniversityChangwon 51140South Korea Department of Convergence Medical Science School of MedicinePusan National UniversityYangsan 50612South Korea Health Convergence Medicine Laboratory Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Studies on varicose veins have focused its effects on physical function;however,whether nonsurgical treatments alter muscle oxygenation or physical function remains ***,the differences in such functions between individuals with varicose veins and healthy individuals remain *** To investigate changes in physical function and the quality of life(QOL)following nonsurgical treatment of patients with varicose veins and determine the changes in their muscle oxygenation during *** We enrolled 37 participants(those with varicose veins,n=17;healthy individuals,n=20).We performed the following measurements pre-and post-nonsurgical treatment in the varicose vein patients and healthy individuals:Calf muscle oxygenation during the two-minute step test,open eyes one-leg stance,30 s sit-to-stand test,visual analog scale(VAS)for pain,Pittsburgh sleep quality index,physical activity assessment,and QOL *** Varicose veins patients and healthy individuals differ in most variables(physical function,sleep quality,and QOL).Varicose veins patients showed significant differences between pre-and post-nonsurgical treatment—results in the 30 sit-to-stand test[14.41(2.45)to 16.35(4.11),P=0.018],two-minute step test[162.29(25.98)to 170.65(23.80),P=0.037],VAS for pain[5.35(1.90)to 3.88(1.73),P=0.004],and QOL[39.34(19.98)to 26.69(17.02),P=0.005];however,no significant difference was observed for muscle *** Nonsurgical treatment improved lower extremity function and QOL in varicose veins patients,bringing their condition close to that of healthy *** studies should include patients with severe varicose veins requiring surgery to confirm our findings.

关键词： Varicose vein Nonsurgical treatment physical function Quality of life Near infrared spectroscopy

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Muscle capacity and physical function in older women:What are the impacts of resistance training?

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Journal of Sport and Health Science 2014年第3期3卷 179-188页

作者： Anne O.Brady Chad R.Straight Department of Kinesiology The University of North Carolina at Greensboro Department of Kinesiology University of Georgia

The number of older adults （individuals ≥65 years）, particularly women, in our society is increasing and understanding the impact of exercise on muscle capacity （e.g., strength and power） and subsequently physical function is of utmost importance to prevent disability and maintain independence. Muscle capacity declines with age and this change negatively impacts physical function in older women. Exercise, specifically resistance training, is recommended to counteract these declines; however, the synergistic relationships between exercise, muscle capacity, and physical function are poorly understood. This review will summarize the literature regarding age-related changes in the aforementioned variables and review the research on the impact of resistance training interventions on muscle capacity and physical function in older women. Recommendations for future research in this area will be discussed.

关键词： Muscle capacity Older women physical function Resistance training

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Evaluating the Impact of a Pilates Intervention on physical function in Children with Hypermobility Spectrum Disorder: A Study Protocol Using Single-Case Experimental Design

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Open Journal of Pediatrics 2021年第1期11卷 55-70页

作者： Elizabeth A. Hornsby Leanne M. Johnston School of Health and Rehabilitation Sciences The University of Queensland Brisbane Australia Kids Care Physiotherapy Brisbane Australia

Background: Pilates has been shown to be an effective intervention for adults with musculoskeletal conditions with only a few examples available in the literature for children. As musculoskeletal pain is a major symptom experienced by children with Hypermobility Spectrum Disorder (HSD), they may benefit from practicing Pilates to improve postural alignment, strength and motor control to effectively distribute movement load and decrease adverse load through involved joints. Method: This study aims to evaluate the impact of a Physiotherapy-led Pilates intervention on school aged children with HSD and the benefits of this approach on pain, physical function and quality of life when delivered in a community-based model of care. A single-case experimental design (SCED) that incorporates a multiple baseline design will be used. Children with HSD, aged from 8 to 12 years, will commence concurrently in this study. Participants will undergo multiple assessments through all phases of the study which incorporates an A-B-A withdrawal design. The initial baseline period will be randomised from 5 to 7 weeks duration, then participants will enter the intervention period for 8 weeks followed by a withdrawal period of 5 weeks. The Physiotherapy-led Pilates intervention will consist of individual, 45 minute bi-weekly sessions, performed on both mat and the Pilates Reformer with an additional home program of mat exercises performed weekly. The study hypotheses are that children will show: 1) a decrease in pain;2) an increase in their physical function as measured by muscle strength, postural control, fatigue and physical activity levels;and 3) an improvement in their Health Related Quality of Life in the domains of physica

关键词： Pilates Pain physical function Hypermobility Children

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Association of Oral Diadochokinesis, physical function and Swallowing function in Community-Dwelling Elderly People

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Advances in Aging Research 2022年第1期11卷 16-25页

作者： Kumiko Sakaguchi Shuichi Hara Department of Department of Speech Language and Hearing Therapy Faculty of Health Sciences Mejiro University Saitama Japan School of Health Science Kyusyu University of Health and Welfare Miyazaki Japan

Objective: Oral diadochokinesis (ODK) has been shown to be associated with oral frailty. In this study, we investigate the relationship between physical function, swallowing function, nutritional evaluation, and each syllable of ODK. Methods: The subjects are 26 elderly people living in an area where they can walk. ODK, tongue pressure, modified water swallowing test, EAT-10, grip strength, MNA-SF, skeletal muscle index, height, weight, and BMI were evaluated. For statistical analysis based on ODK values, the subjects were divided into two groups on the basis of the number of times the syllables /pa/, /ta/, and /ka/ were repeated: 1) The first group with >6 repetitions exceeded six; 2) the second group with ≤5 repetitions. Both groups were compared using the Mann-Whitney U test (Model 1). In addition, the syllables /pa/, /ta/, and /ka/ were also divided among the groups and a comparison was performed (Model 2). Results: In Model 1, the tongue pressure value was significantly higher in the good group (p Conclusion: In community-dwelling elderly people, tongue pressure was positively associated with ODK values for the syllables /pa/ and /ta/, suggesting that tongue pressure may be associated with strength of the lip and tongue tip muscles. Furthermore, it was suggested that the ODK values may even be lower than normal values in the elderly who maintain skeletal muscle mass and thus have adequate tongue pressure;therefore, these indicators may be used as a guideline to assess oral frailty.

关键词： Oral Frailty Oral Diadochokinesis Community-Dwelling Elderly Swallowing function physical function

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Effects of Cardiac Rehabilitation Exercise Protocols on physical function in Patients with Chronic Heart Failure: An Experience from a Resource Constraint Nation

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International Journal of Clinical Medicine 2016年第8期7卷 547-557页

作者： Taofeek O. Awotidebe Rufus A. Adedoyin Michael O. Balogun Rasaq A. Adebayo Victor O. Adeyeye Kayode I. Oke Rita N. Ativie Anthony O. Akintomide Mukadas O. Akindele Department of Medical Rehabilitation College of Health Sciences Obafemi Awolowo University Ile-Ife Nigeria Department of Medicine College of Health Sciences Obafemi Awolowo University Ile-Ife Nigeria Cardiac Care Unit Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife Nigeria Department of Physiotherapy School of Medical Sciences University of Benin Benin Nigeria Department of Medical Rehabilitation College of Health Sciences and Technology University of Nigeria Enugu Campus Enugu Nigeria Department of Physiotherapy College of Allied Health Sciences Bayero University Kano Kano State Nigeria

Objective: This study investigated the effects of cardiac rehabilitation exercise protocols on physical function (PF) in patients with chronic heart failure (CHF). Study Design and Setting: This randomized controlled trial recruited 70 patients who are in stage II CHF with ejection fraction (≤40%) from a Nigerian university teaching hospital. They were randomly assigned into Exercise Group (EG: n = 35) or Control Group (CG: n = 35). physical function, activity of daily living (ADL), distance walked in six minutes and grip strength were assessed using a validated ADL questionnaire, six minute walk test and a hand dynamometer respectively. In addition to medication, EG underwent aerobic and upper extremity resistance exercises thrice weekly for eight weeks while CG used medications only. Data were analyzed using descriptive and inferential statistics. Alpha level was at p p > 0.05). Significant improvements were noticed at fourth week among participants’ ADL (30.0% ± 6.0%), 6MWD (321.7 ± 26.3 m) and VO2 max (8.9 ± 0.4 mL/kg/min) variables within the exercise EG but no significant changes were observed in the CG (p > 0.05). Participants in EG demonstrated more significant improvements in ADL (15.0% ± 5.0%), 6MWD (406.0 ± 29.7 m) and VO2 max (10.3 ± 0.5 mL/kg/min) (p p > 0.05). Conclusions: Cardiac rehabilitation exercise protocols involving self-paced walking, sit-to-stand and upper extremity dynamic strength training improved activity of daily living, walking and functional capacity in patients with stable chronic heart failure.

关键词： Cardiac Rehabilitation Exercise physical function Heart Failure

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Serum 1, 25-Hydroxyvitamin D: A Useful Index of Cognitive and physical functional Impairment in Healthy Older Adults in Japan: A Pilot Study

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Health 2016年第15期8卷 1679-1686页

作者： Noboru Hasegawa Miyako Mochizuki Mayumi Kato Takako Yamada Nobuko Shimizu Akihisa Torii Department of Health and Medical Sciences Ishikawa Prefectural Nursing University Kahoku Japan Kyoto Bunkyo Junior College Uji Japan Aichi Medical College for physical and Occupational Therapy Kiyosu Japan

We enrolled 23 Japanese men (age: 76.0 ± 8.7) and 17 women (age: 78.3 ± 9.3) in this study. The physical function of even a person getting on a wheelchair could be tested in all subjects. Blood was collected by venipuncture and the serum 1, 25-hydroxy vitamin D (1, 25OHD) concentration was measured. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment-Japanese version (MoCA-J) was used for the cognitive function test. physical function was measured objectively using the Timed UP and Go (TUG) and 4-m walking test (4MWS). A significant positive correlation was found between serum 1, 25OHD and MMSE or MoCA-J. It is expected that an elderly person can maintain a mean serum 1, 25OHD level of about 100 pg/mL for preventing early cognitive disorder. In the present study, a significant positive correlation was found between urinary 25-hydroxy vitamin D (25OHD)/creatinine and MMSE or MoCA-J. Our results showed that urinary 25OHD might be a useful biomarker for predicting cognitive disorder. There was a significant negative correlation between serum 1, 25OHD and TUG or 4MWS. These findings suggest that serum 1, 25OHD levels might serve as a useful index to improve cognitive and physical functional impairment.

关键词： Serum 1 25-Hydroxyvitamin D Cognitive function physical function Aging Urinary 25-Hydroxyvitamin D

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DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

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Military Medical Research 2022年第1期9卷 1-11页

作者： Gang Xu Yi-Kun Shi Bin-Da Sun Lu Liu Guo-Ji E Shu He Jian-Yang Zhang Bao Liu Qiu Hu Jian Chen Yu-Qi Gao Er-Long Zhang Institute of Medicine and Equipment for High Altitude Region College of High Altitude Military MedicineArmy Medical UniversityChongqing 400038China Key Laboratory of Extreme Environmental Medicine Ministry of Education of ChinaChongqing 400038China Key Laboratory of High Altitude Medicine People's Liberation ArmyChongqing 400038China

Background:Studies have revealed the protective effect of DL-3-n-butylphthalide(NBP)against diseases associated with ischemic ***,the role of NBP in animals with hypobaric hypoxia has not been *** study investigated the effects of NBP on rodents with acute and chronic hypobaric ***:Sprague-Dwaley rats and Kunming mice administered with NBP(0,60,120,and 240 mg/kg for rats and 0,90,180,and 360 mg/kg for mice)were placed in a hypobaric hypoxia chamber at 10,000 m and the survival percentages at 30 min were ***,the time and distance to exhaustion of drug-treated rodents were evaluated during treadmill running and motor-driven wheel-track treadmill experiments,conducted at 5800 m for 3 days or 20 days,to evaluate changes in physical *** frequency of active escapes and duration of active escapes were also determined for rats in a shuttle-box experiment,conducted at 5800 m for 6 days or 27 days,to evaluate changes in learning and memory *** levels were measured in the gastrocnemius muscle and malonaldehyde(MDA),superoxide dismutase(SOD),hydrogen peroxide(H_(2)O_(2)),glutathione peroxidase(GSH-Px),and lactate were detected in sera of rats,and routine blood tests were also ***:Survival analysis at 10,000 m indicated NBP could improve hypoxia tolerance *** time and distance to exhaustion for mice(NBP,90 mg/kg)and time to exhaustion for rats(NBP,120 and 240 mg/kg)significantly increased under conditions of acute hypoxia compared with control *** treatment also significantly increased the time to exhaustion for rats when exposed to chronic ***,240 mg/kg NBP significantly increased the frequency of active escapes under conditions of acute ***,the levels of MDA and H_(2)O_(2) decreased but those of SOD and GSH-Px in the sera of rats increased under conditions of acute and chronic ***,ATP levels in the gastrocnemius muscle significantly incre

关键词： DL-3-n-butylphthalide Hypobaric hypoxia physical function Learning and memory function Oxidative stress Energy metabolism

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Androgen effects on skeletal muscle： implications for the development and management of frailty

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Asian Journal of Andrology 2014年第2期16卷 203-212,I0007,I0008页

作者： Matthew DL O'Connell Frederick CW Wu The Irish Longitudinal Study on Ageing Department of Medical Gerontology Trinity College Dublin Ireland Andmlogy Research Unit Institute of Human Development Centre for Endocrinology and Diabetes University of Manchester Manchester UK.

Androgens have potent anabolic effects on skeletal muscle and decline with age in parallel to losses in muscle mass and strength. This loss of muscle mass and function, known as sarcopenia, is the central event in development of frailty, the vulnerable health status that presages adverse outcomes and rapid functional decline in older adults. The potential role of falling androgen levels in the development of frailty and their utility as function promoting therapies in older men has therefore attracted considerable attention. This review summarizes current concepts and definitions in muscle ageing, sarcopenia and frailty, and evaluates recent developments in the study of androgens and frailty. Current evidence from observational and interventional studies strongly supports an effect of androgens on muscle mass in ageing men, but effects on muscle strength and particularly physical function have been less clear. Androgen treatment has been generally well-tolerated in studies of older men, but concerns remain over higher dose treatments and use in populations with high cardiovascular risk. The first trials of selective androgen receptor modulators （SARMs） suggest similar effects on muscle mass and function to traditional androgen therapies in older adults. Important future directions include the use of these agents in combination with exercise training to promote functional ability across different populations of older adults, as well as more focus on the relationships between concurrent changes in hormone levels, body composition and physical function in observational studies.

关键词： ageing androgens body composition frailty muscle physical function sarcopenia selective androgen receptor modulators sex hormones testosterone

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Effects of video game-based therapy in an adolescent with cerebral palsy: A case report

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World Journal of Clinical Cases 2023年第36期11卷 8595-8602页

作者： Huda Aliah Mohd Iqbal Wei Sheng Ho Asfarina Zanudin Hafifi Hisham Nor Azlin Mohd Nordin Physiotherapy Programme Centre for Rehabilitation and Special Needs StudiesFaculty of Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul AzizKuala Lumpur 50300Malaysia

BACKGROUND Herein,we report the case of a 13-year-old boy with spastic quadriplegia cerebral palsy(CP)at Gross Motor function Classification System(GMFCS)level II,en-gaging in a 6-wk video game-based therapy(VBT)*** study aimed to offer essential insights regarding VBT’s impact on enhancing the physical function and improving the quality of life(QoL)of adolescents diagnosed with *** report provides a distinctive viewpoint that can inform and direct future clinical practices and research *** SUMMARY The boy presented with moderate mobility,balance,and overall *** faced challenges with diminished lower limb strength,which affected his daily living and physical fitness *** participant was diagnosed with spas-tic quadriplegic CP at GMFCS level *** participated in a 6-wk program of VBT using a play *** innovative approach incorporates warm-up exercises,interactive activities,and cool-down routines,targeting various movements,in-cluding single-leg stance,weight shifting,kicking,jumping,marching,and *** VBT,the strength of the left hip extensor significantly increased from 199.3 N to 541.3 *** covered as part of a 6-min walk test increased by 82 *** Paediatric QoL Inventory score increased dramatically by 25.9%.CONCLUSION VBT is an innovative,individualized therapy that enhances physical function and QoL in CP,emphasizing its role in ambulatory patients.

关键词： Video game physical function Quality of life Cerebral Palsy Case report

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Impact of community-based exercise program participation on aerobic capacity in women with and without breast cancer

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World Journal of Clinical Oncology 2021年第6期12卷 468-481页

作者： Jordan T Lee Chad W Wagoner Stephanie A Sullivan Dean J Amatuli Kirsten A Nyrop Erik D Hanson Lee Stoner Brian C Jensen Hyman B Muss Claudio L Battaglini Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNC 27599United States Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC 27599United States Department of Medicine Division of CardiologyUniversity of North Carolina at Chapel HillChapel HillNC 27599United States Lineberger Comprehensive Cancer Center University of North CarolinaChapel HillNC 27599United States

BACKGROUND Evidence for exercise as an efficacious strategy to improve aerobic capacity of breast cancer survivors(BCS)has come largely from intervention studies conducted in laboratory *** is an increasing need to translate to community-type settings,but the efficacy of those interventions using gold standard evaluation is not *** To investigate whether similar improvement in aerobic capacity(maximal oxygen consumption[VO2])measured with gold standard testing can be achieved through a community-based setting in *** A peak cardiopulmonary exercise test(VO2peak),6-min walk test(6MWT),and timed up and go test(TUG)were assessed pre-and post-16 wk of progressive intensity aerobic and strength training exercise at a community *** The sample consisted of 31 early BCS(physical function for early-stage BCS but potentially not to the same extent observed in laboratory-based randomized controlled *** research is needed to explore barriers and facilitators of exercise engagement in community-based centers to maximize training benefits for adults with cancer.

关键词： Aerobic capacity Breast cancer Community-based Exercise physical function

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