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LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation

Acta Pharmaceutica Sinica B 2024年第7期14卷 2942-2958页

作者： Shishi He Guowei Huang Rong Lei Rurong Jia Zhanghai He Jiewen Chen Hongyan Huang Zixian Huang Ailifeire Yilihamu Xun Li Zilin Zhuang Mengjia Han Xueman Chen Di Huang Yan Nie Guangdong Provincial Key Laboratory of Malignant tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology Shantou University Medical CollegeShantou 515041China School of Basic Medical Science Southern Medical UniversityGuangzhou 510515China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Breast Medicine Affiliated Foshan Maternity and Child Healthcare HospitalSouthern Medical UniversityFoshan 528000China Department of Breast Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Breast phyllodes tumor(PT)is a rare fibroepithelial neoplasm with potential malignant *** non-coding RNAs(lncRNAs)play multifaceted roles in various cancers,but their involvement in breast PT remains largely *** this study,microarray was leveraged for the first time to investigate the role of lncRNA in *** identified lncRNA ZFPM2-AS1 was significantly upregulated in malignant PT,and its overexpression endowed PT with high tumor grade and adverse ***,we elucidated that ZFPM2-AS1 promotes the proliferation,migration,and invasion of malignant PT in *** ZFPM2-AS1 through nanomaterial-mediated siRNA delivery in patient-derived xenograft(PDX)model could effectively inhibit tumor progression in ***,our findings showed that ZFPM2-AS1 is competitively bound to CDC42,inhibiting ACK1 and STAT1 activation,thereby launching the transcription of *** conclusion,our study provides evidence that ZFPM2-AS1 plays a pivotal role in the pathogenesis of breast PT,and suggests that ZFPM2-AS1 could serve as a prognostic indicator for patients with PT as well as a promising novel therapeutic target.

关键词： LncRNA phyllodes tumor ZFPM2-AS1 Cell division cycle 42 Activated cdc42 kinase 1 Signal transducer and activator of transcription 1 TNF receptor superfamily member 19 Nano particles

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Pulmonary metastases 12 years after a mastectomy for borderline phyllodes tumor

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Chinese Medical Journal 2011年第24期124卷 4376-4377页

作者： NIE Xiao-meng WANG Yang YAO Xiao-peng Department of Respiratory DiseasesChanghai Hospital the Second Military Medical University Shanghai 200433 China Department of Pathology Changhai Hospital the Second Military Medical University Shanghai 200433 China

phyllodes tumor is a rare breast tumor. A 45-year-old woman who underwent left mastectomy 12 years ago was found to have infiltrates in both lungs in a health examination. Combining histological examinations of the lung and breast samples the diagnosis of borderline phyllodes tumor metastases to the lung was made. It is the longest interval to our knowledge that the metastases occurred 12 years after primary phyllodes tumor.

关键词： phyllodes tumor neoplasm metastasis breast neoplasms

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Giant phyllodes tumor of the breast:a case report

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The Chinese-German Journal of Clinical Oncology 2010年第11期9卷 674-676页

作者： Dong Xia Huaiquan Zuo Yi Quan Hongliang Dong Liang Xu Department of General Surgery The First Affiliated Hospital Luzhou Medical College Luzhou 646000 China

Objective： The aim of the study was to report a case with a giant phyllodes tumor of the left breast and discuss the diagnostic and management challenges. Methods： A 47-year-old female patient was admitted to our center （Department of General Surgery, the First Affiliated Hospital, Luzhou Medical College, China） due to a large left breast mass for about 2.5 years. Core tissue biopsy showed mixed epithelial-stromal proliferation suggestive of a phyllodes tumor. Left modified radical mastectomy with dissection of level Ⅰ and level Ⅱ lymph nodes was performed. Results： The pathologic findings of this proce- dure were consistent with borderline phyllodes tumor. The tumor measured 47.5 cm× 37,0 cm× 28.0 cm and weighed 9.79 kg ex vivo. Conclusion： To our knowledge, this patient presented one of the biggest phyllodes tumors of breast in all cases reported in English-language publications so far.

关键词： phyllodes tumor breast diagnosis surgery

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