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phyllanthi fructus:A modal medicinal and food homologous item in quality evaluation

Chinese Herbal Medicines 2023年第3期15卷 360-368页

作者： Gefei Li Yurou Jiang Dingkun Zhang Li Han Taigang Mo Sanhu Fan Haozhou Huang Junzhi Lin State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Sanajon Pharmaceutical Group Chengdu 610045China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu610072China

phyllanthi fructus is a highly unique medicine and food homologous item,which exhibits distinctive flavor,notable nutritional value,and abundant pharmacological *** has enormous potential in the creation of health products and ***,due to the unique laws of quality formation and transfer of phyllanthi fructus,its appearance,shape,chemical compositions,nutrients,and sensory flavors are frequently greatly influenced by botanical resources,the processing and storage *** a result,the current quality evaluation model is difficult to meet the needs of phyllanthi fructus as a medicine and food homologous item in the development of diversified *** paper constructs the hierarchical utilization mode of phyllanthi fructus based on its unique quality formation and transmission laws,explores the quality evaluation model for food-oriented use and medicinal-oriented use,respectively,and systematically describes the quality evaluation idea under diversified application *** paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of phyllanthi fructus.

关键词： flavor homology of medicine and food phyllanthi fructus Phyllanthus emblica L. polyphenol quality evaluation sensory evaluation

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An Herbal Formula (GPC) Suppresses the Releases of Pro-Inflammatory Effectors in Lipopolysaccharide/Peptidoglycan-Activated RAW264.7 Macrophages and Reduces the Extent of Chemical-Induced Acute/Chronic Inflammation in Rodents

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Chinese Medicine 2016年第4期7卷 153-165页

作者： Pou Kuan Leong Hoi Yan Leung Wing Man Chan Jihang Chen Huawei Zhu Jialing Ning Yiting Yang Chung Wah Ma Kam Ming Ko Division of Life Science Hong Kong University of Science and Technology Hong Kong China Infinitus (China) Company Ltd. Guangzhou China

Pharyngitis (an inflammation in the pharynx) is a commonly occurring symptom of upper respiratory tract infection in patients suffering from common cold. The high prevalence of upper respiratory tract infection necessitates a safe and effective antiinflammatory agent for pharyngitis. Chinese herbal medicine, which has been clinically prescribed for thousands of years, may offer a basis for the treatment of common cold as well as the amelioration of pharyngitis. In the present study, we investigated the in vitro and in vivo anti-inflammatory activities of a Chinese herbal formula, namely GPC, which is comprised of Glycyrrhiza Radix, Platycodonis Radix, Citri Reticulatae Pericarpium, phyllanthi fructus and Taraxaci Herba. Incubation with GPC (30, 100 and 300 μg/mL) suppressed the releases of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and nitric oxide in lipopolysaccharide/peptidoglycanactivated RAW264.7 macrophages. In addition to the cell-based study, long-term treatment with GPC (0.35, 1.05 and 2.10 mL/kg/day × 30 doses) was found to reduce the extent of inflammation in animal models of carrageenan-induced paw edema (acute inflammation) as well as cotton pellet-induced granuloma formation (chronic inflammation) in mice. The ability of GPC to enhance the tracheobronchial expectorant action suggested its immunomodulatory activity in the respiratory tract. This postulation was supported by the observation that GPC reduced the degree of pharyngitis and reversed the changes in plasma TNF-α and IL-6 levels in capsaicininduced pharyngitis in rats. The ensemble of results suggests that GPC may offer a promising prospect for alleviating the extent of pharyngitis by virtue of antiinflammatory activities.

关键词： Pharyngitis Glycyrrhiza Radix Platycodonis Radix Citri Reticulatae Pericarpium phyllanthi fructus Taraxaci Herba

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