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Effects of aqueous extract from red Liriope platyphylla on phthalic-anhydride-induced atopic dermatitis in Interleukin-4/Luciferase/Consensus non-coding sequence-1 transgenic mice evaluated in terms of luciferase signal and general phenotype biomarkers

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Journal of Traditional Chinese Medicine 2017年第4期37卷 475-485页

作者： Moon Hwa Kwak Ji Eun Kim Jun Go Hong Joo Son Hee Seob Lee Jin Tae Hong Dae Youn Hwang College of Natural Resources and Life Science/Life and Industry Convergence Research Institute Pusan National UniversityMiryang 627-706South of Korea College of Human Ecology Pusan National UniversityBusan 609-735south of Korea College of Pharmacy and Medical Research Center Chungbuk National UniversityChungju 361-763south of Korea College of Pharmacology Chungbuk National UniversityChungju 361-763south of Korea

OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 ***: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot ***: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated ***: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia.

关键词： Dermatitis, Atopic Liriope plant Interleukin-4 Luciferases Mice, transgenic phthalic anhydrides Immunoglobulin E

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Copper（I）-Catalyzed Trifluoromethylation of phthalic Anhydride Derivatives with （Trifluoromethyl）trimethylsilane

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Chinese Journal of Chemistry 2013年第7期31卷 945-949页

作者： Mingxi Wu Mingjin Wang Song Cao Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

An efficient copper-catalyzed trifluoromethylation of substituted phthalic anhydrides using （trifluoromethyl） trimethylsilane （Me3SiCF3） as a nucleophilic trifluoromethylating reagent in the presence of 1,10-phenanthroline and KF, followed by quenching the reaction mixture with water has been developed. A possible mechanism was suggested.

关键词： trifluoromethylation copper(l)-catalyzed phthalic anhydrides (trifluoromethyl)trimethylsilane

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