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The marriage of sealant agent between structure transformable silk fibroin and traditional Chinese medicine for faster skin repair

引用

Chinese Chemical Letters 2022年第3期33卷 1599-1603页

作者： Rongjun Zhang Youbin Zheng Tianqing Liu Ning Tang Lianzhi Mao Lihan Lin Jiahui Ye Luoyijun Xie Wenwen Hu Weiwei Wu Wenzhen Liao Miaomiao Yuan The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhen 518033China Institute of Molecular Medicine(IMM) Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China Department of Chemical Engineering and Russell Berrie Nanotechnology Institute Technion-Isr1ael Institute of TechnologyHaifa 3200003Israel School of Advanced Materials and Nanotechnology Interdisciplinary Research Center of Smart SensorsXidian UniversityXi'an 710126China Department of Nutrition and Food Hygiene School of Public HealthSouthern Medical UniversityGuangzhou 510515China

Fast skin repair is critical for less infection, less pain and high quality of life, which is still limited with undesirable rehabilitation speed and side effects. Currently, laser-activated silk sealant agent without suture and gauze has been demonstrated promising for fast skin repair taking advantage of its structural transformation after heating. Nevertheless, more efficient healing effects and less side effects of laseractivated silk sealant agent remains challenging due to absence of suitable photo-thermal materials and robust/biomimetic protein materials. In this work, the marriage between silk protein and Rehmanniae radix preparata(a kind of the traditional Chinese herb) has been demonstrated as a novel and effective way to achieve an excellent healing effect for skin repair. The non-toxicity, high photothermal conversion efficiency and healing mechanism are systematically studied and proved. This new methodology might shed a new light for combining dark traditional Chinese medicine and silk fibroin for advanced wound healing technology.

关键词： Rehmanniae radix preparata Silk fibroin Sealant agent photo-thermal effect Skin repair

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