检索结果-南通市图书馆

Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3983-4000页

作者： Li, Ru Wei, Riqing Liu, Chenxin Zhang, Keying He, Sixiao Liu, Zhifeng Huang, Junhao Tang, Youyong An, Qiyuan Lin, Ligen Gan, Lishe Zhao, Liying Zou, Xiaoming Wang, Fudi Ping, Yuan Ma, Qiang Southern Med Univ Affiliated Hosp 7 Foshan 528244 Peoples R China Southern Med Univ Sch Lab Med & Biotechnol Dept Biopharmaceut Guangzhou 510000 Peoples R China Southern Med Univ Sch Lab Med & Biotechnol Guangdong Prov Key Lab Immune Regulat & Immunother Guangzhou 510000 Peoples R China Gen Hosp Southern Theatre Command PLA Med Crit Care Med Guangzhou 510000 Peoples R China Chinese Peoples Liberat Army Gen Hosp Natl Clin Res Ctr Geriatr Dis Guangdong Branch Ctr Guangzhou 510000 Peoples R China University Macao Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Ave Univ Macau 999078 Peoples R China Zhejiang Chinese Med Univ Sch Pharmaceut Sci Hangzhou 311402 Peoples R China Southern Med Univ Nanfang Hosp Sch Clin Med 1 Dept Gen Surg Guangzhou 510000 Peoples R China Zhejiang Univ Affiliated Hosp 4 Affiliated Hosp 1 Inst Translat MedSch MedSch Publ HlthState Key Hangzhou 310000 Peoples R China Univ South China Affiliated Hosp 1 Affiliated Hosp 2 Hengyang Med SchSch Publ HlthBasic Med Sci Hengyang 421200 Peoples R China Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310000 Peoples R China Zhejiang Univ Med Ctr Liangzhu Lab Hangzhou 310000 Peoples R China

With the escalating prevalence of global heat waves, heat stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms of liver injury, heat stroke-induced damage is characterized by heat cytotoxicity and heightened inflammation, directly contributing to elevated mortality rates. While clinical assessments have identified elevated bilirubin levels as indicative of Kupffer cell dysfunction, their specific correlation with heat stroke liver injury remains unclear. Our hypothesis proposes the involvement of Kupffer cell ferroptosis during heat stroke, initiating IL-1,beta-mediated inflammation. Using single-cell RNA sequencing of murine macrophages, a distinct and highly susceptible Kupffer cell subtype, Clec4F(+)/CD206(+), emerged, with heme oxygenase 1 (HMOX-1) playing a pivotal role. Mechanistically, heat-induced HMOX-1, regulated by early growth response factor 1, mediated ferroptosis in Kupffer cells, specifically in the Clec4F(+)/CD206(+) subtype (KC2), activating phosphatidylinositol 4-kinase beta and promoting PI4P production. This cascade triggered NLRP3 inflammasome activation and maturation of IL-1,beta. These findings underscore the critical role of targeted therapy against HMOX-1 in ferroptosis within Kupffer cells, particularly in Clec4F(+)/CD206(+) KCs. Such an approach has the potential to mitigate inflammation and alleviate acute liver injury in the context of heat stroke, offering a promising avenue for future therapeutic interventions. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association andInstitute of Materia Medica, Chinese Academy of Medical Sciences.

关键词： Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1 NLRP3 INFLAMMASOME PROTECTIVE ROLE MACROPHAGES EXPRESSION HO-1 ACTIVATION IL-1-beta DEATH SUSCEPTIBILITY PYROPTOSIS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：