检索结果-南通市图书馆

Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

Journal of Integrative Medicine 2021年第1期19卷 66-77页

作者： Pukar Khanal basanagouda M.Patil Department of Pharmacology and Toxicology KLE College of Pharmacy BelagaviKLE Academy of Higher Education and ResearchBelagavi 590010India

Objective:Duranta repens is reported to contain a wide array of secondary metabolites,including aamylase and a-glucosidase inhibitors,and-has potent antioxidant *** present study evaluated the network pharmacology of ***(whole plant)with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of *** in streptozotocin-nicotinamide-induced diabetes mellitus in ***:Phytoconstituents of *** were retrieved from an open-source database and published literature,and their targets were predicted for diabetes mellitus using binding Db and the therapeutic target ***-protein interaction was predicted using STRING,and pathways involved in diabetes mellitus were identified using the Kyoto Encyclopedia of Genes and Genomes pathway ***,ADMET profile(absorption,distribution,metabolism,excretion and toxicity)and cytotoxicity of compounds modulating proteins involved in diabetes were predicted using Mol Soft,admet SAR2.0 and CLC-Pred,*** interaction network among phytoconstituents,proteins and pathways was constructed using Cytoscape,and the docking study was performed using Auto *** hydroalcoholic extract of *** was evaluated using streptozotocin-nicotinamide-induced diabetes mellitus animal model for 28 d,followed by an oral glucose tolerance *** the end of the study,biochemical parameters like glycogen content,hepatic enzymes,antioxidant biomarkers and lipid profiles were ***,the liver and pancreas were collected for a histopathology ***:Thirty-six different secondary metabolites from *** were identified to regulate thirty-one targets involved in diabetes mellitus,in which protein-tyrosine phosphatase 1 b(PTP1 b)was primarily *** analysis of modulated proteins identified 12 different pathways in diabetic pathogenesis in which the phosphatidylinositol 3-kinase-protein kinase b(PI3 K-Ak

关键词： Diabetes mellitus Duranta repens DurantaninⅠ Network pharmacology phosphatidylinositol 3-kinase-protein kinase b signaling pathway protein-tyrosine phosphatase 1b

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：