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Possible prediction of myeloid and lymphoid crises in chronic myelocytic leukemia at onse by determining the methylation status of the major breakpoint cluster region

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南通大学学报(医学版) 2003年第1期 116-116页

作者： Tanaka K Mansyur A Tazawa H Iwato K Kyo T Dohy H Kamada N

To investigate the relationship between the pattern of methylation at the major breakpoint cluster region(M-BCR) and transformation of chronic myelocytic leukemia(CML) from the chronic to the blastic phase,the M-BCR methylation status was examined serially from chronic to blastic phase in 23 CML *** DNA of mononuclear cells from bone marrow or peripheral blood was digested with restriction enzymes HpaⅡand BgⅢ,and hybridized with a 5’ M-BCR *** methylation status was stable during evolution of CML from chronic to the myeloid blastic *** in both phases showed consistent methylation patterns consisting of fully methylated rearranged fragments of variable size,4.8,3.1/3.0,and 2.7/2.5 ***,there was substantial heterogeneity in methylation patterns in patients with lymphoid *** lymphoid-crisis patients studied in blastic phase showed a pattern distinct from that of the chronic phase in the same patient,as well as from the myeloid pattern,suggesting cell lineage-specific M-BCR ***,in four of six patients with lymphoid crisis,the chronic-phase patterns were different from those of cases with myeloid ***-positive and -negative acute lymphocytic leukemia(ALL) showed methylation patterns different from those of lymphoid crisis in *** the number of patients with lymphoid crisis studied has been limited,these results suggest that analysis of M-BCR methylation status may be of clinical use in distinguishing lymphoid from myeloid crises and predicting the cell lineage of a crisis when the disease is still in the chronic phase.(C) 2001 Elsevier Science *** rights reserved.

关键词： chronic myelogenous leukemia tumor-suppressor gene receptor CPG island philadelphia-chromosome DNA methylation BCR hypermethylation lineage sites

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