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Efficacy of Nilotinib versus Imatinib in philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib

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Journal of Cancer Therapy 2018年第11期9卷 883-897页

作者： Amen Hamdy Zaky Aly Ahmed EL Sayed Mohammed Khalifa Esraa Abdallah Abdelkariem Gadallah Department of Medical Oncology South Egypt Cancer Institute Assuit University Assiut Egypt Department of Clinical Oncology Faculty of Medicine Sohag University Sohag Egypt Department of Medical Oncology Sohag Cancer Center Sohag Egypt

Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib at 400 mg BID in CML patients with suboptimal molecular response after at least 12 months of daily dose 400 mg of imatinib therapy. Patients and Methods: This study included a total number of 50 patients, divided into two groups (25 patients each). The first group (Group I): Patients received imatinib at 400 mg BID, second group (Group II): Patients had a suboptimal molecular response to imatinib and received nilotinib at 400 mg BID in early chronic phase. During the two years period of data collection, the primary end included median survival. The secondary end included response rate, type of response, duration of response and progression free survival. Also side effects were recorded. Patients were followed up every month by complete and differential blood counts, liver function test, renal function test and (PCR) every three months for two year. Results: Nilotinib group had significantly higher frequency of major molecular response (MMR) where 23 (92%) patients achieved it while only 16 (64%) patients in Imatinib group achieved MMR (P = 0.01). Nilotinib had better toxicities profile than Imatinib. Conclusion: Both Nilotinib and high dose Imatinib achieved response in CML patients with suboptimal response with rapid and deeper molecular response, better survival outcomes and less side effects in nilotinib.

关键词： Nilotinib Imatinib philadelphia Positive Chronic Myeloid Leukemia Patients Warning Molecular Response

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The philadelphia Orchestra’s Triumphal Return to China

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China & The World Cultural Exchange 1993年第5期59卷 38-40页

MUSIC is an internationalart,enabling people allover the world to com-municate with and understand eachother.The first cultural troupe sentby the American government to visitChina 20 years ago was the Philadel-phia Orchestra.Their perform-ances contributed greatly to Sino-American cultural exchange andpromoted friendship between theAmerican and Chinese people.InMay 1993 the philadelphia Orches-tra came to China again as theAmerican people’s cultural

关键词： philadelphia enabling again music Sonata scene performing honored Minor quickly

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Unusual cytogenetic abnormalities associated with philadelphia chromosome

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World Journal of Hematology 2014年第3期3卷 115-117页

作者： Sanjeev Kumar Sharma Anil Handoo Dharma Choudhary Nitin Gupta Department of Hemato-oncology and Bone Marrow Transplant BL Kapur Superspeciality Hospital

Cytogenetic abnormalities are the hallmark of leukemias. We report here two cases of unusual cytogenetic abnormalities associated with philadelphia chromosome, one with mixed phenotypic acute leukemia showing monosomy 7 and t(9;22)(q34;q11.2) and the other with chronic myeloid leukemia and additional translocation involving chromosomes 10 and 13. Both patients achieved complete remission following imatinib based treatment.

关键词： philadelphia chromosome Cytogenetic abnormalities

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Reconfiguring the Silk Road: New Research on East-West Exchange in Antiquity. philadelphia, PA: University of Pennsylvania Museum of Archaeology and Anthropology

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Journal of Ancient Civilizations 2018年第1期 131-135页

作者： Victor H.MAIR Shi Xueliang IHAC NENU

ISBN:978-1-934536-68-1,pp.136,31 color,9 b/w illus,$59.95.Since"The Belt and Road Initiative"reviving the ancient trade land and maritime trade routes was proposed by the Chinese state at the end of 2013,the routes linking East and West by land and sea,whereby silk,spice,and glass were transported by ship or camel,are frequently mentioned.From East Asia to Europe,it garners increasing attention from institutes,think-tanks,and forums

关键词： In PA philadelphia Reconfiguring the Silk Road University of Pennsylvania Museum of Archaeology and Anthropology New Research on East-West Exchange in Antiquity

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CONVERGENCE OF LEGENDRE METHODS FOR NAVIER-STOKES EQUATIONS

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Journal of Computational Mathematics 1994年第4期12卷 298-311页

作者： CHEN, ZT E, WN LUOYANG EDUC INST LUO YANGPEOPLES R CHINA UNIV CALIF LOS ANGELES DEPT MATHLOS ANGELESCA 90024

This paper is concerned with spectral type of methods using Legendre polynomials. Both Galerkin and collocation approximations for the Navier-Stokes equations are considered and their rates of convergence are obtained. As a consequence, it is shown that these methods achieve spectral accuracy if the solutions to the Navier-Stokes equations are smooth.

关键词： Stokes Navier estimates incompressible discretization philadelphia Heidelberg Berlin Chebyshev Burgers

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Reinforcing the Repertoire

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Beijing Review 2023年第47期66卷 26-27页

作者： Zhao Wei 不详

A journey of musical diplomacy and 50 years of friendship The concert hall of the National Center for the Performing Arts(NCPA)in Beijing erupted in thunderous applause on the evening of November 11.The excitement was palpable as the sound cascaded through the nearly full auditorium.Another wave of enthusiastic cheers echoed as the spotlight shone brightly on cellist Jan Vogler and eight members of the philadelphia Orchestra on stage upon the encore invitation of the young conductor Sun Yifan.

关键词： audit philadelphia invitation

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NCPA May Festival 2019 Closing Concert: The philadelphia Orchestra

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China Today 2019年第5期68卷 9-9页

Date: May 17-18, 2019 Venue: National Center for the Performing Arts Prices: RMB 280, 480, 600, 780, 900, 1080, 1280 The philadelphia Orchestra is one of the preeminent orchestras in the world, renowned for its distinctive sound, desired for its keen ability to capture the hearts and imaginations of audiences, and admired for a legacy of imagination and innovation on and off the concert stage.

关键词： NCPA philadelphia Orchestra

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JAK2 exon 12 mutations in patients with philadelphia(Ph) chromosome-negative myeloproliferative neoplasms

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China Medical Abstracts(Internal Medicine) 2012年第4期29卷 234-234页

作者：王婕妤 Instit Hematol&Blood Dis Hosp CAMS&PUMC

Objective To investigate JAK2 exon 12 mutations in patients with philadelphia (Ph) chromosome-negative myeloproliferative neoplasms (MPN) and the clinical characteristics of patients with JAK2 exon 12 mutants. Methods... 详细信息

关键词： neoplasms chromosome philadelphia mutation sequencing poietin plasmid erythro exogenous cloning

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China Tourism Goes to philadelphia Travel & Adventure Show

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China & The World Cultural Exchange 2019年第3期85卷 7-7页

The Sixth philadelphia Travel & Adventure Show took place at Pennsylvania Convention Center in philadelphia, the USA, from March 9 to 1 0. China National Tourist Office, New York, used pandas and Peking Opera symbolic meaning as the key visual style,"Beautiful China" national tourism brand as the theme to present "China Beyond Imaginations , in philadelphia, delivered news about tourism in China and caught attention of lots of participants.

关键词： Tourism philadelphia Travel participants

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Effect of VE-cadherin on sentitivity to Imatinib in Sup-B15 philadelphia chromosome positive acute lymphoblastic leukemia cells

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China Medical Abstracts(Internal Medicine) 2013年第3期30卷 184-184页

作者：张焕新 Dept Hematol Affil HospXuzhou Med Coll

Objective To investigate the sensitivity of imatinib mesylate (IM) on Sup-B15 Ph+acute lymphoblastic leukemia (ALL) cells knockdown of VE-cadherin (CD144) ,and to further explore its mechanism.Methods CD144in Sup-B15 ... 详细信息

关键词： lymphoblastic cadherin chromosome philadelphia mesylate catenin stably RNA sensitized inhibiting

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