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Differential modulation of bradykinin-induced relaxation of endothelin-1 and phenylephrine contractions of rat aorta by antioxidants

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Acta Pharmacologica Sinica 2007年第10期28卷 1566-1572页

作者： Ogechukwu ANOZIE Richonda ROSS Adebayo O OYEKAN Momoh A YAKUBU Vascular Biology UnitCenter for Cardiovascular Diseases College of Pharmacy and Health Sciences Texas Southern University Houston Texas 77004 USA

Aim:We tested the hypothesis that bradykinin （BK）-induced relaxation of phe-nylephrine （PE） and endothelin-1 （ET-1） contractions can be differentially modu-lated by reactive oxygen species （ROS）.Methods:Aortic rings isolated fromSprague-Dawley rats were used for the *** contribution of ROS to PE(1×10-9-1×10-5mol/L)-and ET-1 (1×10-10-1×10-8mol/L)-induced contractions andthe influence of ROS in BK (1×10-9-1×10-5mol/L) relaxation of PE (1×10-7mol/L) orET-1 (1×10-9mol/L)-induced tension was evaluated in the aorta in the presence orabsence of the following antioxidants:catalase （CAT,300 U/mL）,superoxidedismutase （SOD,300 U/mL）,and vitamin C (1×10-4mol/L).Results:Tension gen-erated by ET-1 (1×10-9mol/L) or PE (1×10-7mol/L) was differentially relaxed by BK(1×10-5mol/L),producing a maximal relaxation of 75%±5% and 35±4%,*** BK (1×10-5mol/L)-induced relaxation of PE (1×10-7mol/L) tension was signifi-cantly enhanced from 35%±4% （control） to 56%±9%,60%±5%,and 49%±6% bySOD,CAT,and vitamin C,respectively （P<0.05,n=8）.However,the relaxation ofET-1 (1×10-9mol/L) tension was significantly attenuated from 75%±5% （control）to 37%±9%,63%±4%,and 39%±7% by SOD,CAT,and vitamin C,respectively（P<0.05,n=8）.On the other hand,CAT had no effect on PE-induced tension,whileSOD enhanced PE-induced tension （36%,P<0.05,n=10） and vitamin C attenuated（66%,P<0.05,n=8） the tension induced by *** contrast,SOD or vitamin C hadno effect,but CAT attenuated （44%,P<0.05,n=9） the tension induced by ***:We have demonstrated that O2-and H2O2differentially modulate BKrelaxation in an agonist-specific manner.O2-attenuates BK-induced relaxation ofPE contraction,but contributes to the relaxation of ET-1 contraction.O2-seems toinhibit PE contraction,while H2O2contributes to ET-1-induced ***,ROS differentially modulate vascular tone depending on the vasoactive agentthat is used to generate the tone.

关键词： bradykinin endothelin-1 phenylephrine reactive oxygen species superoxide hydrogen peroxide relaxation contraction antioxidants

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Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)

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World Journal of Gastroenterology 2014年第6期20卷 1594-1601页

作者： Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura Center for Genetic Engineering and Biotechnology "Juan B. Zayas" Hospital National Center for the Coordination of Clinical Trials

AIM: To compare the efficacy and safety of recombinant streptokinase (rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.

关键词： Streptokinase Suppository phenylephrine Thrombolysis Hemorrhoids Randomized clinical trial

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Effects　of　Isoprenaline，phenylephrine　on　Heart　and　Influence　of　Nifedipine　on　These　Effects

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1994年第4期14卷 216-219页

作者：马业新余枢赵华月 Department of Internal Medicine Tongji Hospital Tongji Medical University Wuhan

In a perfused isovolumetrically contracting rat heart model, the effects of isoprenaline(IPN) and phenylephrine (PE) on myocardial contraction and relaxation were investigated,and the influence of nifedipine on these effects was studied. Both IPN and PE increased the myocardial contraction and improved its relaxation, but some differences *** (10 nmol/L)substantially inhibited the PE-mediated inotropic effect, but in case of IPN-mediated inotropic ones, it did *** was assumed that there may be various types of slow channels, one was activated by IPN,and the other, by PE.

关键词： isoprenaline phenylephrine nifedipine myocardial contraction myocardial relaxation slow channel

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Bolus norepinephrine and phenylephrine for maternal hypotension during elective cesarean section with spinal anesthesia:a randomized,double-blinded study

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Chinese Medical Journal 2020年第5期133卷 509-516页

作者： Xian Wang Mao Mao Su-Su Zhang Zhao-Hui Wang Shi-Qin Xu Xiao-Feng Shen Department of Anesthesiology Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Background:In recent years,norepinephrine has attracted increasing attention for the management of maternal hypotension during elective cesarean section with spinal *** bolus is a widely used administration paradigm for vasopressors in obstetric anesthesia in ***,in this randomized,double-blinded study,we compared the efficacy and safety of equivalent bolus norepinephrine and phenylephrine for rescuing maternal post-spinal ***:In a tertiary women’s hospital in Nanjing,China,102 women were allocated with computer derived randomized number to receive prophylactic 8 mg norepinephrine(group N;n=52)or 100 mg phenylephrine(group P;n=50)immediately post-spinal anesthesia,followed by an extra bolus of the same dosage until delivery whenever maternal systolic blood pressure became lower than 80%of the *** primary outcome was standardized maternal cardiac output(CO)reading from spinal anesthesia until delivery analyzed by a two-step *** hemodynamic parameters related to vasopressor efficacy and safety were considered as secondary *** side effects and neonatal outcomes were collected as ***:Compared to group P,women in groupNhad a higherCO(standardizedCO5.8±0.9 vs.5.3±1.0 L/min,t=2.37,P=0.02)and stroke volume(SV,standardized SV 73.6±17.2 vs.60.0±13.3 mL,t=4.52,P0.05).Conclusions:Compared to equivalent phenylephrine,intermittent bolus norepinephrine provides a greater CO for management of maternal hypotension during elective cesarean section with spinal anesthesia;however,no obvious maternal or neonatal clinical adv

关键词： Norepinephrine phenylephrine Cardiac output Cesarean section

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Effect of administration of phenylephrine immediately after low dose insemination on pregnancy rates in mares

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Open Journal of Obstetrics and Gynecology 2013年第10期3卷 722-726页

作者： Theresa Beachler Renan Sper C. Scott Bailey James Shewmaker C. Nick Buchanan Anne Josson-Schramme Michael Whitacre College of Veterinary Medicine North Carolina State University Raleigh USA School of Veterinary Medicine Ross University Basseterre Saint Kitts and Nevis

There is considerable pressure on equine veterinarians to achieve good pregnancy rates with very small doses of semen. phenylephrine administration in the rabbit increased numbers of oviductal, uterine, and cervical sperm, myometrial contractions, and fertilized ova after low dose insemination. The use of phenylephrine to enhance uterine contractility and fertility has not been investigated in the mare. Thus, the objective of this study was to determine if phenylephrine administration would result in clinically acceptable pregnancy rates in mares bred by low dose insemination. The hypothesis (Ha) was that pregnancy rates would be significantly higher in mares receiving phenylephrine compared to saline controls. Six pony mares and eight horse mares were enrolled in this study. Mares were inseminated within 24 hours of ovulation with 30 million progressively motile spermatozoa from a single fertile stallion. Immediately following insemination, mares were administered either phenylephrine (0.06 mg/kg) or 1mL of saline via IV injection. Pregnancy status was determined 14 days following ovulation via transrectal ultrasonography. Pregnancy rates in phenylephrine treated mares were 44% (4/9) while 22% (2/9) in saline-treated mares (P > 0.05).

关键词： Artificial Insemination Low Dose Insemination Equine phenylephrine

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Comparison the effect of ephedrine and phenylephrine in treatment of hypotension after spinal anesthesia during cesarean section

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 192-196页

作者： Atashkhoyi Simin Fardiazar Zahra Hatami Marandi Pouya Torab Reza AnesthesiologyAnesthesiology Alzahra Hospital Tabriz University of Medical Sciences Tabriz Iran Obstetrics & Gynecology Alzahra Hospital Tabriz University of Medical Sciences Tabriz Iran Tabriz University of Medical Sciences Alzahra Hospital Tabriz University of Medical Sciences Tabriz Iran

Background and Objective: The effectiveness of ephedrine and/or phenylephrine, in treatment of hypotension secondary to spinal anesthesia for cesarean section and their effects on fetal/neonatal outcome were studied. Methods and Materials: Sixty healthy parturients were randomly assigned to two groups;group E (n = 33) received boluses 5 mg/ml increments ephedrine and group P (n = 27) received a boluses of phnylephrine 100 μg/ml increments for treatment of hypotension after spinal block during cesarean section. Changes in maternal blood pressure and heart rate, and incidence of nausea-vomiting, neonatal Apgar score at 1 and 5 minutes of delivery, and umbilical arterial blood gas values were recorded. Results: There were no differences in treatment of hypotension following sympathectomy after spinal block with two drugs. Neonatal outcome was similar in two groups. There were not significant differences in umbilical arterial values in two groups. Conclusion: Ephedrine and phenylephrine are both effective vasopressores for treatment of hypotension associated to spinal block during cesarean section without adverse effects on infants/neonates.

关键词： Cesarean Section Spinal Anesthesia Hypotension Ephedrine phenylephrine Fetal/Neonatal Outcome

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Separation of chiral drugs with sulfobutylether-β-cyclodextrin bycapillary zone electrophoresis

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Chinese Chemical Letters 1999年第1期10卷 39-42页

作者： Jun Ying LIU Yi Yang DONG Tian Song WANG Hu Wei LIU Al Jin HUANG yi Liang SUNI Zeng Pei SUN(Department of Chemistry． Peking University． Beijing 100871)(Natlonal Institute for the Control of Pharmaceutical and Biological Products，Beijing 100050) Department of Chemistry Peking University Beijing 100871 China Natl. Inst. Contr. Pharmaceutical B. Beijing 100050 China

Sulfobutylether－β－cyclodextrin（SBE－β－CD）was used as a chiral selector tor separatingten chlral drugs with resolution 1．2 by capillary zone electrophoresls（CZE）， The backgroundelectrolylc solution comprised of 120 mmol／L Britton－Robinson buffer（BRB） containing1 ～10mmol／L SBE－β－CD with the pH value adjusted from 5．0－6．8． Five of the drugs were better resolvedthan those previously reported with neutral CDs．

关键词： Chiral separation sulfobutylether-β-cyclodextrin capillary zone electrophoresis anlsodamlne bencynonate econazole esmolol glycopynonate lobeline methoxamine phenylephrine plnacidll terazosin

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Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study

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World Journal of Transplantation 2021年第4期11卷 114-128页

作者： Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu Department of Anesthesiology University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Department of Surgery Miami Transplant Institute/University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Division of Nephrology of the Department of Medicine University of Miami/Jackson Memorial HospitalMiamiFL 33136United States

BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney *** exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is *** To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 *** primary outcome was the occurrence of *** The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressurephenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/*** We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine.

关键词： Delayed graft function Outcome Kidney transplant Risk factors phenylephrine Mean arterial pressure

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EFFECT OF THE EXCITATION OF ADRENOCEPTORS ON THE PACEMAKER CURRENT I_f OF SHEEP CARDIAC PURKINJE FIBRES IN “ISCHEMIA”SOLUTION

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Medical Bulletin of Shanghai Jiaotong University 1995年第2期18卷 74-82页

作者：徐有秋张照高汝

The effect of ischemia like solution and high concentration of isoprenaline and phenylephrine in that solution on normal pacemaker current If of sheep cardiac Puekinje fibres were observed After perfusing the preparations with “ischemia” solution 15, 30, and 60 min, the amplitude of If current at all measured membrane potentials (from -60 to -120 mV) decreased (n=7,pphenylephrine decreased the amplitude of If current further in “ischemia” solution (n= 7, P<0.05-0.01), the activatior curve of If current shifted to left side further. The above results indicate that the normal pacemaker current was inhibited in “ischemia” condition even in the presence of high concentration of beta and alpha adrenoceptor agonists so the genesis of ischemic ventricular arrhythmia is hardly due to the abnormal enhancement of normal ventricular pacemaker activity.

关键词： pacemaker current ischemia cardiac Purkije fibres isoprenaline phenylephrine

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Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats

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Open Journal of Medicinal Chemistry 2012年第3期2卷 61-71页

作者： Joyce Cristina de Oliveira Carla Renata Kitanish Antonietto Angélica Cristina Scalabrini Talita Sanches Marinho Larissa Pernomian JoséWilson NCorrêa Carolina Baraldi Araujo Restini School of Nutrition University of Ribeirao PretoRibeirao PretoBrazil School of Pharmaceutical Sciences University of Ribeirao PretoRibeirao PretoBrazil Department of Physics and Chemistry Faculty of Pharmaceutical Sciences from Ribeirao PretoLaboratory of PharmacologyUniversity of Sao PauloRibeirão PretoBrazil Federal University of Amazonas ManausBrazil School of Medicine Animal Experimental LaboratoryUniversity of Ribeirao PretoRibeirao PretoBrazil

Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.

关键词： Hypertension Aorta Superoxide Resveratrol phenylephrine Reactive Species of Oxygen(ROS)

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