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Amphipathic phenylalanine-Induced Nucleophilic-Hydrophobic Interface Toward Highly Reversible Zn Anode

Nano-Micro Letters 2024年第9期16卷 95-109页

作者： Anbin Zhou Huirong Wang Fengling Zhang Xin Hu Zhihang Song Yi Chen Yongxin Huang Yanhua Cui Yixiu Cui Li Li Feng Wu Renjie Chen Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Technology Research Institute Beijing Institute of TechnologyJinan 250300People’s Republic of China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081People’s Republic of China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621900People’s Republic of China

Aqueous Zn^(2+)-ion batteries(AZIBs),recognized for their high security,reliability,and cost efficiency,have garnered considerable attention.However,the prevalent issues of dendrite growth and parasitic reactions at the Zn electrode interface significantly impede their practical application.In this study,we introduced a ubiquitous biomolecule of phenylalanine(Phe)into the electrolyte as a multifunctional additive to improve the reversibility of the Zn anode.Leveraging its exceptional nucleophilic characteristics,Phe molecules tend to coordinate with Zn^(2+)ions for optimizing the solvation environment.Simultaneously,the distinctive lipophilicity of aromatic amino acids empowers Phe with a higher adsorption energy,enabling the construction of a multifunctional protective interphase.The hydrophobic benzene ring ligands act as cleaners for repelling H_(2)O molecules,while the hydrophilic hydroxyl and carboxyl groups attract Zn^(2+)ions for homogenizing Zn^(2+)flux.Moreover,the preferential reduction of Phe molecules prior to H_(2)O facilitates the in situ formation of an organic-inorganic hybrid solid electrolyte interphase,enhancing the interfacial stability of the Zn anode.Consequently,Zn||Zn cells display improved reversibility,achieving an extended cycle life of 5250 h.Additionally,Zn||LMO full cells exhibit enhanced cyclability of retaining 77.3%capacity after 300 cycles,demonstrating substantial potential in advancing the commercialization of AZIBs.

关键词： Zn anode phenylalanine Adsorption energy Solvation sheath

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phenylalanine diminishes M1 macrophage inflammation

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Science China(Life Sciences) 2023年第12期66卷 2862-2876页

作者： Qingzhuo Zhang Siyuan Chen Yan Guo Fang He Jian Fu Wenkai Ren Guangdong Laboratory of Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and Technology Southwest UniversityChongqing 400715China

Emerging evidence suggests that amino acids dictate the effector functions of immune cells;however, whether and how phenylalanine(Phe) orchestrates the polarization of macrophages is not understood. Here, we determined that Phe attenuated lipopolysaccharide(LPS) and P. multocida serotype A strain CQ2(PmCQ2) infection-induced inflammation in vivo. Furthermore, we demonstrated that Phe inhibited the production of interleukin(IL)-1β and tumor necrosis factor(TNF)-α in proinflammatory(M1) macrophages. Phe reprogrammed the transcriptomic and metabolic profiles and enhanced oxidative phosphorylation in M1 macrophages, which reduced the activation of caspase-1. Notably, the valine-succinyl-CoA axis played a critical role in Phe-mediated inhibition of IL-1β production in M1 macrophages. Taken together, our findings suggest that manipulating the valine-succinyl-CoA axis provides a potential target for preventing and/or treating macrophage-related diseases.

关键词： IL-1β macrophage phenylalanine succinyl-CoA valine

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Journal of Integrative Plant Biology 2023年第4期65卷 879-880页

作者： Jingjing Tan Ping He De‐Yu Xie Journal of Integrative Plant Biology Institute of BotanyCASChina Department of Plant and Microbial Biology North Carolina State UniversityRaleighNC27695USA

How plants produce the important defense hormone salicylic acid(SA)has been studied for almost 50 years.The current understanding is that in land plants,SA is biosynthesized from chorismate through the isochorismate(I... 详细信息

关键词： phenylalanine insight ammonia

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Study on the Extraction of L-phenylalanine with Organo-phosphoric Acid in Two and Three-phase System

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Chinese Journal of Chemistry 2002年第12期20卷 1499-1505,1460页

作者：张莉傅洵胡正水李秋红徐婷 Department of Applied Chemistry Qingdao University of Science and Technology Qingdao Shandong 266042 China

The extraction behaviors of L-phenylalanine by di-(2,4,4-trimethylpentyl) phosphinic acid, di-(2,4,4-trimethylpentyl)-monothiophosphinic acid and di-(2-ethylhexyl) phosphoric acid were studied in both two-phase and th... 详细信息

关键词： extraction three-phase Cyanex272 Cyanex302 phenylalanine

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Hydrogenation of phenylpyruvic acid to phenylalanine catalyzed by Ni-B/SiO_2

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Journal of Natural Gas Chemistry 2008年第3期17卷 303-308页

作者： Qunfang Liang Aiqing Zhang Lin Li Key Laboratory of Catalvsis and Materials Science of the State Ethnic Affairs Commission ＆ Ministry of Education College of Chemistry and MateriaLs Science South-Central University for Nationalities Wuhan 430074 Hubei China

phenylalanine （Phe） is a significant amino acid that cannot be synthesized by human themselves but must be taken from environment. It was initially found that the nanosized amorphous Ni-B/SiO2 alloy prepared by the chemical reduction method was an effective catalyst for the preparation of Phe from phenylpyruvic acid （PPA） by amination and hydrogenation. It has been found that the amorphous Ni-B/SiO2 alloy catalyst exhibits superior activity and selectivity to the traditional catalysts Raney Ni and Urushibara nickel. The effects of reaction time, amounts of catalysts and ammonia solution, reaction temperature, and H2 pressure on the reaction have been investigated systematically. The results indicated that the yield of Phe was 97.9%, and the selectivity for Phe reached 98.9% when the reaction was carried out for 3 h at 333 K and 2.0 MPa of H2 with m（Cat.）： m（PPA） = 0.6 ： 1.0 and n（NH3）： n（PPA） = 3 ： 1. The catalysts were characterized by XRD, AAS, XPS, BET, and TEM, and the relationship between the catalyst structure and the catalytic activity was discussed in detail. It was found that the reason why Ni-B/SiO2 amorphous alloy catalyst was much more active for the preparation of Phe could be accounted for by the presence of electron-rich Ni due to electron donation from alloying B; the smaller size of Ni-B particles, the larger specific surface area of Ni-B/SiO2.

关键词： Ni-B/SiO2 amorphous alloy phenylalanine phenylpyruvic acid hydrogenation catalyst

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Sucrose as chiral selector for determining enantiomeric composition of phenylalanine by UV-vis spectroscopy and chemometrics

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Chinese Chemical Letters 2012年第9期23卷 1055-1058页

作者： Qian Qian Li Jia Duan Li Jun Wu Yue Huang Guo Tang Shun Geng Min College of Science China Agricultural UniversityChina Beijing 100193

The determination of enantiomeric composition by partial least squares （PLS） modeling of UV-vis spectral data was investigated for samples of phenylalanine （phe） using sucrose as a chiral auxiliary. And a new data preprocess method, reference band normalization, was introduced to eliminate the spectral variations due to the changes of total concentration of phe. The determination coefficient （R2） and the standard error of calibration set （SEC） of 13 standard samples are 0.9987 and 0.0128 respectively. The standard error of validation set （SECV） of 7 validation samples is 0.0049. The standard error of predict （SEP） of 6 blind samples for evaluating the robustness of the model is 0.0366. The regression model is robust to determine enantiomeric composition when total concentration varied. It is demonstrated that the reference band normalization is a convenient method of compensating for variations in total concentrations without knowing that in advance.

关键词： Chiral analysis Partial least squares Sucrose Enantiomer phenylalanine

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THE IMMOBILIZATION OF AMINOACYLASE AND THE RESOLUTION OF D,L-phenylalanine

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Science China Chemistry 1991年第6期34卷 641-650页

作者：韩际宏姜坪何炳林 Dept.of Biochem. Graduare School of medical SciencesCornell UniversityNew YorkNY 10021USA Institute of Polymer Chemistry Nankai University Tianjin 300071 PRC

A polymer with suitable physical characters and matched functional groups was synthesized,and used as a supporter to immobilize aminoacylase. The results showed that this supporterhad high immobilizing capacity and high selectivity for aminoacylase. Immobilized amino-acylase had high specific activity. In this paper, we determine the physical and chemicalcharacters of aminoacylase for resolution of D,L--phenylalanine, including its optimum tem-perature, pH, ion concentration, activated ion, substrate concentration, thermal stability anddenaturation. The immobilized aminoacylase was used to resolve the D,L-phenylalaninecontinuously. Thc resolved products was separated and purified with ion-exchange resins. L-phenylalanine solution was concentrated by vacuum evaporation and its hydrochloride wasformed. Checking of final product with polarimeter showed high yield and purity.

关键词： aminoacylase immobilization phenylalanine racemate resolution

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Effect of Chloride Ions and Dissolved Oxygen on the Deactivation of phenylalanine Ammonia-lyase

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Chinese Science Bulletin 1994年第19期39卷 1620-1623页

作者：李清彪由英才陶雪何炳林 Institute of Polymer Chemistry Nankai University Tianjin 300071 PRC

With the method of synthesizing the L-phenylalanine by trans-cinnamic acid and ammonia in the presence of phenylalanine ammonialyase (PAL) under high pH and high concentration of cinnamic acid, it is not favorable for... 详细信息

关键词： phenylalanine ammonia-lyase deactivation L-phenylalanine chloride ion dissolved oxygen.

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Demand for L-phenylalanine Increases Rapidly

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China Chemical Reporter 2007年第17期18卷 21-21页

L-phenylalanine is an important aminoacid with biological activity.Man andanimal can not synthesize it themselvesand have to get it from the outsideworld.It is one of the eight indispens-able amino acids and also an

关键词： thousand phenylalanine synthesize eliminated ferme

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Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia

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World Journal of Pediatrics 2019年第1期15卷 66-71页

作者： Pei-Zhong Bao Jun Ye Lian-Shu Han Wen-Juan Qiu Hui-Wen Zhang Yong-Guo Yu Jian-Guo Wang Xue-Fan Gu Department of Endocrinology and Genetics Shanghai Institute of PediatricsXinhua HospitalShanghai Jiaotong University School of Medicine1665 Kong Jiang RoadShanghai 200092China

Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis.Methods We compared the urine neopterin (N),biopterin (B),isoxanthopterin (Iso),B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD,and found the most specific pterin biomarkers by ROC analysis.A positive cut-off value of urine pterins was determined.The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated,and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared.The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined.Results (1) Urinary B,B%,Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P phenylalaninemias and improve the accuracy of diagnosis.This approach is worthy of further development and increased utilization.

关键词： 6-Pyruvoyltetrahydropterin synthase Hyperphenylalaninemia Isoxanthopterin phenylalanine hydroxylase Pterin

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