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PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer

Journal of Genetics and Genomics 2021年第7期48卷 640-651页

作者： Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Medical Oncology The First Affiliated HospitaHengyang MedicalSchoolUniversity of South ChinaHengyangHunan 421001China School of Life Science and Technology Shanghai Tech UniversityShanghai 200120China CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to ***,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely *** comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to *** or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly ***,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with *** chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway *** findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment.

关键词： SCLC Heterogeneity Growth pattern phenotype transition Drug resistance PI3K/Akt/mTOR pathway

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Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

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Bioactive Materials 2021年第1期6卷 244-261页

作者： Yiming Niu Zhenzhen Wang Yuchen Shi Lei Dong Chunming Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeMacao SARChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210093China

A coordinated interaction between osteogenesis and osteoimmune microenvironment is essential for successful bone *** particular,macrophages play a central regulatory role in all stages of bone *** on the signals they sense,these highly plastic cells can mediate the host immune response against the exterior signals of molecular stimuli and implanted scaffolds,to exert regenerative potency to a varying *** this article,we first encapsulate the immunomodulatory functions of macrophages during bone regeneration into three aspects,as sweeper,mediator and *** introduce the phagocytic role of macrophages in different bone healing periods(‘sweeper’)and overview a variety of paracrine cytokines released by macrophages either mediating cell mobilisation,vascularisation and matrix remodelling(‘mediator’),or directly driving the osteogenic differentiation of bone progenitors and bone repair(‘instructor’).Then,we systematically classify and discuss the emerging engineering strategies to recruit,activate and modulate the phenotype transition of macrophages,to exploit the power of endogenous macrophages to enhance the performance of engineered bone tissue.

关键词： Macrophages Bone regeneration Biomaterial-host interaction Inflammation phenotype transition

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