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phenolic extract of Morchella angusticeps peck inhibited the proliferation of HepG2 cells in vitro by inducing the signal transduction pathway of p38/MAPK

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Journal of Integrative Agriculture 2020年第11期19卷 2829-2838页

作者： LI Fu-hua ZHENG Shao-jie ZHAO Ji-chun LIAO Xia WU Su-rui MING Jian College of Food Science Southwest UniversityChongqing 400715P.R.China Research Center of Food Storage&Logistics Southwest UniversityChongqing 400715P.R.China Kunming Edible Fungi Institute All China Federation of Supply and Marketing CooperativesKunming 650223P.R.China

Morchella angusticeps Peck,one of the most popular edible mushrooms,has attracted great attention due to its delicious taste and healthy ***,both its biological effects and the possible mechanism of action have not yet been *** investigated the anti-proliferative activity of the phenolic extract derived from Morchella angusticeps Peck(MPE)against HepG2 human hepatocellular carcinoma *** showed that MPE at non-cytotoxicity doses significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner with inhibitory rates ranging from 18 to 90%(P<0.01).The possible mechanism might be that MPE induced apoptosis through initiating the mitochondrial death pathway by regulating Bax,Bcl-2 and cleaved *** the other hand,MPE might trigger cell cycle arrest at G0/G1/S phases by managing p21,Cyclin D1,cyclin-dependent kinases-4(CDK4)and proliferating cell nuclear antigen(PCNA).Additionally,MPE downregulated TRAF-2 and p-p53,while upregulated p-ASK1 and ***,it could be inferred that MPE might induce the anti-proliferative function to HepG2 cells through the p38/MAPK signal transduction pathway.

关键词： Morchella angusticeps Peck phenolic extract cell cycle apoptosis anti-proliferation

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Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells

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Food Science and Human Wellness 2023年第5期12卷 1510-1518页

作者： Wen Xia Ersheng Gong Yanyun Lin Bisheng Zheng Wenhan Yang Tong Li Sheng Zhang Peng Li Ruihai Liu Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health(111 Center) School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510641China School of Public Health and Health Management Gannan Medical UniversityGanzhou 341000China Key Laboratory of Tropical Crop Products Processing of Ministry of Agriculture and Rural Affairs Agricultural Products Processing Research InstituteChinese Academy of Tropical Agricultural SciencesZhanjiang 524001China Department of Food Science Cornell UniversityIthaca 14853USA Stem Cell Research and Cellular Therapy Center Affi liated Hospital of Guangdong Medical UniversityZhanjiang 524001China

Polyphenol-rich foods have been shown to be good for cancer prevention as powerful antioxidants. In this study, the mechanisms of wild pink bayberry free phenolic extract(WPBFE)inhibiting the proliferation and inducing apoptotic of MDA-MB-231 breast cancer cells was examined. The main phenolic acids and flavonols in WPBFE were gallic acid((18.83 ± 0.44)μg/g FW)and myricetin((1.52 ± 0.05)μg/g FW), respectively. The maximum inhibition rate of WPBFE at non-cytotoxicity dose(below 80 mg/mL)was 81%. Western blotting analysis showed that WPBFE could cause the arrest of cell cycle in G0/G1 phase by down-regulating expression levels of PCNA, CDK4, cyclin D1 and up-regulating the expression level of p21. Meanwhile, WPBFE induced apoptosis through initiating the mitochondrial death pathway by up-regulating cleaved caspase-3 and enhancing the ratio of Bax/Bcl-2, with the maximum expression levels of 1.29 and 2.03 folds that of control group, respectively. Further study of the upstream protein, we found that WPBFE down-regulated TRAF2, while upregulated p-ASK1, p-p38 and p-p53. Furthermore, WPBFE could down-regulate the expression of p-PI3K and p-Akt. These observations indicated that WPBFE might play an anticancer role through regulating the p38 MAPK together with PI3K/Akt pathway.

关键词： phenolic extract Breast cancer Cell cycle Apoptosis Cell proliferation

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phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways

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Food Science and Human Wellness 2023年第4期12卷 1071-1080页

作者： Fuxia Hu Chao Liu Fengqin Wang Changxin Zhou Maotong Zhu Dongxiao Sun-Waterhouse Zhaosheng Wang Key Laboratory of Food Processing Technology and Quality Control in Shandong Province College of Food Science and EngineeringShandong Agricultural UniversityTaian 271018China Key Laboratory of Novel Food Resources Processing Ministry of Agriculture and Rural AffairsKey Laboratory of Agro-Products Processing Technology of Shandong ProvinceInstitute of Agro-Food Science and TechnologyJinan 250100China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand

Chaenomeles speciosa(Sweet)Nakai cultivated widely in temperate regions possesses anti-inflammatory properties,however,the underlying molecular mechanisms remain not fully *** this study,a purified phenolic extract of *** rich in chlorogenic acid,procyanidin B1 and catechin(determined by HPLC-Q-TOF-MS/MS)exhibited dose-dependent anti-inflammatory effects on lipopolysaccharide(LPS)-treated RAW264.7 *** extract at 30μg/mL was most potent and enabled most cells in normal morphology under LPS stimulation without causing *** extract suppressed the levels of nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β),and the mRNA and protein expressions of nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2).The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B(NF-κB)and mitogen-activated protein kinase(MAPK)signaling ***,the phenolic extract from *** is a desirable anti-inflammatory agent for inflammatory conditions to meet the rising demand for natural and cost-effective therapeutics.

关键词： Chaenomeles speciosa phenolic extract Purification Anti-inflammatory

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Fermented Psidium guajava leaves regulate the gut microbiota and improve metabolic alterations in diabetic mice

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Food Bioscience 2023年第1期51卷 220-234页

作者： Zhenfeng Huang Zheng Fang Anping Wu Fei Shen Zhenqiang Wu School of Biology and Biological Engineering South China University of TechnologyGuangzhou510006PR China Pan Asia(Jiangmen)Institute of Biological Engineering and Health Jiangmen529080PR China

The phenolic extract from fermented Psidium guajava leaves(PFGL)helps to improve diabetes;however,its hypoglycemic and hypolipidemic mechanisms remain *** this study,gut microbiota modulation and glucose-lipid metabolism was *** results showed that dietary supplement of PFGL enriched in quercetin glucosides significantly improved serum glucose-lipid profiles as well as insulin resistance in diabetic *** gut microbiota of diabetic mice was modulated by PFGL(200 mg/kg),causing an abundance of Bacteroidetes,Prevotellaceae,and Alistipes and a reduced the presence of Firmicutes and *** levels of short-chain fatty acids(SCFA)activated G protein-coupled receptor signaling that induced peptide YY release to promote insulin ***-induced serum metabolite disorders that are involved in glycerophospholipid metabolism and tryptophan metabolism were restored by *** protein expression of metabolic enzymes including phospho-adenosine 5’-monophosphate-activated protein kinase,fatty acid synthase,acyl-coenzyme A oxidase,and diacylglycerol aeyltransferase 2 were also regulated to promote glucoselipid *** particular,gut microbiota enriched with Alistipes genera and SCFA metabolic regulation were closely correlated with diabetes-related *** findings provide a theoretical support for the development and application of PFGL for the treatment of diabetes.

关键词： Fermented Psidium guajava leaves phenolic extract Gut microbiota Host metabolism Hypoglycemic Hypolipidemic

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