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Histological Studies of Atrazine Toxicity on the Thyroid Gland in Rats

Biomedical and Environmental Sciences 1996年第1期9卷 60-66页

作者： I. N. KORNILOVSKAYA M. V. GORELAYA V. S. USENKO L. V. GERBILSKY AND V. A. BEREZIN(Dept. of Histology, Dniepropetrovsk Medical Institute, Dept. of Biochemistry, Dniepropetrovsk State University, Gagarin Ave. 72,Dniepropetrovsk 320625,Ukraine) Dept. of Histology Dniepropetrovsk Medical Institute Ukraine.

Little is known about the toxic activity of the atrazine (a herbicide, commonly used in agricultural production) on the thyroid gland. In this study the compound was administered orally in female albino rats at sublethal exposure equivalent to 0.2 LD50 doses for 6 and 12 days. At termination of dosing the anesthetized animals were killed and blood was drawn for the determination of serum triiodothyronine (T3) and thyroxin (T4). A dose-dependent decrease of serum T3 concentration was observed in all the groups (control: 0.57 nmol·L-1; 6 days: 0.35 nmol·L-1; 12 days: 0.21 nmol·L-1). The thyroid gland was examined light-microscopically. Bouin's solution-fixed thyroids were embedded in paraffin and sections cut at 6 μm, stained separately with toluidine blue according to Slinchenko's method. Histologically in experimental groups epithelium featured small cuboidal cells and occasional structures of the follicles confluence within epitheliomers. A dose-dependent changes of the following parameters were observed: (a) increasing of number of follicle-building thyroid cells; (b) increasing of follicular volume, (c) decreasing of nucleus volume. Investigation of the whole population of thyroid mast cells disclosed no change in degranulation intensity. By contrast, degranulation intensity was decreased in perifollicular mast cells from groups treated with atrazine in dose-dependent *** are no changes observed in degranulation of stromal mast cells. These results suggesting that differences in response to the atrazine might account for an aspect of the functional heterogeneity within the rat thyroid mast cell population.

关键词： cytes Histol micrometer pharmacol Girard Stevens Fournier Minsk Behaviour chloro

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CARDIOVASCULAR SYSTEM

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China Medical Abstracts(Internal Medicine) 2004年第4期21卷 204-214页

2004474 Clinical efficacy and safety of torasemide in congestive heart failure patients. Li Yishi (李一石), et al. Dept Clin pharmacol, Cardiovasc Instit & Fuwai Hosp, CAMS & PUMC,Beijing 100037. Chin Cir J 2004;19(4)... 详细信息

关键词： CAMS congestive pharmacol false restenosis grafted stent radial grafting dimer

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Acknowledgments to reviewers of World Journal of Gastrointestinal pharmacology and Therapeutics

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World Journal of Gastrointestinal pharmacology and Therapeutics 2012年第1期3卷 7-7页

Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastrointestinal pharmacology and *** editors and authors of the articles submit... 详细信息

关键词： reviewers expertise submitted grateful editing evaluating Australia Neuroscience Assistant pharmacol

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Acknowledgments to reviewers of World Journal of Gastrointestinal pharmacology and Therapeutics

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World Journal of Gastrointestinal pharmacology and Therapeutics 2010年第5期1卷 123-123页

Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastrointestinal

关键词： reviewers expertise grateful evaluating editing submitted Immunology rejected pharmacol Australia

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Acknowledgments to reviewers of World Journal of Gastrointestinal pharmacology and Therapeutics

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World Journal of Gastrointestinal pharmacology and Therapeutics 2012年第5期3卷 83-83页

We acknowledge our sincere thanks to our *** reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of our World Series *** the editors of the journals and authors of the manuscripts submitted to the journals are grateful to the following reviewers for reviewing the articles(either published or rejected) over the past period of time.

关键词： reviewers expertise submitted grateful reviewing rejected Australia Assistant pharmacol Surgery

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Acknowledgments to reviewers of World Journal of Gastrointestinal pharmacology and Therapeutics

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World Journal of Gastrointestinal pharmacology and Therapeutics 2011年第1期2卷 9-9页

Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastrointestinal

关键词： reviewers expertise grateful evaluating editing submitted Surgery rejected pharmacol Australia

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Acknowledgments to reviewers of World Journal of Gastrointestinal pharmacology and Therapeutics

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World Journal of Gastrointestinal pharmacology and Therapeutics 2011年第6期2卷 52-52页

Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastrointestinal pharmacology and Therapeutics. The editors

关键词： reviewers expertise grateful evaluating editing submitted Neuroscience Vancouver rejected pharmacol

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Acknowledgments to reviewers of World Journal of Gastrointestinal pharmacology and Therapeutics

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World Journal of Gastrointestinal pharmacology and Therapeutics 2012年第3期3卷 36-36页

We acknowledge our sincere thanks to our reviewers. Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of our World Series Journals. Both the editors ... 详细信息

关键词： reviewers expertise submitted grateful Australia reviewing Brazil Neuroscience Assistant pharmacol

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Instructions to authors

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World Journal of Gastrointestinal pharmacology and Therapeutics 2010年第4期1卷 89-92页

GENERAL INFORMATION World Journal of Gastrointestinal pharmacology and Therapeutics (World J Gastrointest pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI:10.4292),is a bimonthly,openaccess (OA),peer-reviewed

关键词： bimonthly pharmacol reviewers pharmacology editorial citation comment http contributions figures

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***

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外科研究与新技术 1993年第4期 222-223页

***930711 A new experimental model of acute haemor-rhagic necrotizing pancreatitis in *** Jie,et *** pharmacol,Hubei TCM & PharmChina Medical Abstracts(Internal Medicine)

关键词： necrotizing retrograde Hubei pharmacol hundred fifty differentiated Wuhan abnormal 金永

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