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Current Medical Science 2020年第3期40卷 407-421页

作者： Yi-fan WANG Meng-meng PAN Xu YU Li XU School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Fluorescent nanoparticles have good chemical stability and photostability,controllable optical properties and larger stokes *** light of their designability and functionability,the fluorescent nanoparticles are widely used as the fluorescent probes for diverse *** enhance the sensitivity and selectivity,the combination of the fluorescent nanoparticles with the molecularly imprinted polymer,*** imprinted fluorescent nanoparticles(MIFN),was an effective *** sensor based on MIFN(the MIFN sensor)could be more compatible with the complex sample matrix,which was especially widely adopted in medical and biological *** this mini-review,the construction method,detective mechanism and types of MIFN sensors are *** current applications of MIFN sensors in pharmaceutical analysis,including pesticides/herbicide,veterinary drugs/drugs residues and human related proteins,are highlighted based on the literature in the recent three ***,the research prospect and development trend of the MIFN sensor are forecasted.

关键词： fluorescent sensor molecularly imprinted polymer pharmaceutical analysis fluorescent nanoparticles

Measurement uncertainty in pharmaceutical analysis and its application

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Journal of pharmaceutical analysis 2014年第1期4卷 1-5页

作者： Marcus Augusto Lyrio Traple Alessandro Morais Saviano Fabiane Lacerda Francisco Felipe Rebello Lourencon Department of Pharmacy Faculty of Pharmaceutical Sciences University of Sao Paulo

The measurement uncertainty provides complete information about an analytical result. This is very important because several decisions of compliance or non-compliance are based on analytical results in pharmaceutical industries. The aim of this work was to evaluate and discuss the estimation of uncertainty in pharmaceutical analysis. The uncertainty is a useful tool in the assessment of compliance or non-compliance of in-process and final pharmaceutical products as well as in the assessment of pharmaceutical equivalence and stability study of drug products.

关键词： Measurement uncertainty Method validation pharmaceutical analysis Quality control

Determination of Vitamin B_1 in pharmaceutical Preparations by Flow-injection analysis with Biamperometric Detection

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Chemical Research in Chinese Universities 2005年第6期21卷 650-653页

作者： LI Li-jun CHENG Hao ZHAO Chuan HU Xiao-ge Department of Biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 P. R. China Institute of Analytical Science Northwest University Xi＇an 710069 P. R. China

A new electrochemical method for the on-line determination of vitamin B1 is presented. Based on dead-stop endpoint biamperometry by using two platinum foil electrodes with an applied potential difference of 150 mV, vitamin B1 can be oxidized by hexacyanoferrate （ Ⅲ ） in a sodium hydroxide medium via a reversible indicating couple Fe（ CN）6^4- /Fe（CN）6^3- The cell current is linear with the concentration of vitamin B1 in the concentration range of 4. 0 × 10^-6-1.0 × 10^ -3 mol/L with a detection limit of 8.0 ×10 ^-7 mol/L（0. 27 μg/mL）. Most familiar excipients, ions and vitamins do not interfere with the determination of vitamin B1. The method displays the advantages of simplicity, high efficiency（ 180 samples/h）, and high selectivity, and is suitable for the determination of vitamin B1 in pharmaceutical preparations.

关键词： pharmaceutical analysis Biamperometry Vitamin B1 How-injection analysis

Research and application of fluorescence system on norfloxacin-terbium-phen-SDBS

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Journal of Rare Earths 2012年第8期30卷 842-846页

作者：吕玉光李烨赵悦辉杨立滨江欣王莹吴兴华 College of Pharmacy Jiamusi University Provincial Key Laboratory of Biological Agents College of PharmacyJiamusi University Institute for Drug Control of Jiamusi

Fluorescence characteristics of complex system of rare earth terbium （Tb3＋）, norfloxacin, 1,10-phenanthroline（1,10-phen） and sur- factant sodium dodecyl benzene sulfonate （SDBS） had been studied by using fluorescence spectroscopy. In a buffer solution （pH=6.3）, the fluorescence intensity of the norfloxacin-Tb3＋（NFLX-Tb3＋） system had been remarkably enhanced by SDBS and 1,10-Phen. When excited at 335 nm, a good linear relationship between fluorescence intensity of NFLX-Tb3＋ system and NFLX concentration was obtained in the range of 8× 10-8-4× 10-6 mol/L, and the linear equation was F=2× 10^8 CNFLX＋22.7 with correlation coefficient of 0.9959. In addition, this method was compared with some previous literatures, the proposed method had relatively higher sensitivity and lower detect limit. The method was sim- ple, rapid, sensitive, practical and suitable for direct analysis of pharmaceutical preparation. It was successfully applied to determine the cap- sules, human serum and urine in real pharmaceutical samples.

关键词： norfloxacin terbium 1,10-phenanthroline sodium dodecyl benzene sulfonate fluorescence spectra pharmaceutical analysis rare earths

Microneedle-based interstitial fluid extraction for drug analysis:Advances,challenges,and prospects

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Journal of pharmaceutical analysis 2023年第2期13卷 111-126页

作者： Shuwen Ma Jiaqi Li Lixia Pei Nianping Feng Yongtai Zhang Department of pharmaceutical Sciences Shanghai University of Traditional Chinese MedicineShanghai201203China Institute of Traditional Chinese Medicine Surgery Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200032China

Similar to blood,interstitial fluid(ISF)contains exogenous drugs and biomarkers and may therefore substitute blood in drug ***,current ISF extraction techniques require bulky instruments and are both time-consuming and complicated,which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with ***,microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent *** integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring,while the integration of monitoring and delivery functions in wearable devices allows real-time dose ***,we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges.

关键词： Microneedle Interstitial fluid Biomarker pharmaceutical analysis Diagnosis

Automated and miniaturized screening of antibiotic combinations via robotic-printed combinatorial droplet platform

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1801-1813页

作者： Fangchi Shao Hui Li Kuangwen Hsieh Pengfei Zhang Sixuan Li Tza-Huei Wang Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Department of Mechanical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA

Antimicrobial resistance(AMR)has become a global health crisis in need of novel *** this end,antibiotic combination therapies,which combine multiple antibiotics for treatment,have at-tracted significant attention as a potential approach for combating *** facilitate advances in anti-biotic combination therapies,most notably in investigating antibiotic interactions and identifying synergistic antibiotic combinations however,there remains a need for automated high-throughput plat-forms that can create and examine antibiotic combinations on-demand,at scale,and with minimal reagent *** address these challenges,we have developed a Robotic-Printed Combinatorial Droplet(RoboDrop)platform by integrating a programmable droplet microfuidic device that generates antibiotic combinations in nanoliter droplets in automation,a robotic arm that arranges the droplets in an array,and a camera that images the array of thousands of droplets in *** further implement a resazurin-based bacterial viability assay to accelerate our antibiotic combination *** a demonstration,we use RoboDrop to corroborate two pairs of antibiotics with known interactions and subsequently identify a new synergistic combination of cefsulodin,penicillin,and oxacillin against a model *** *** therefore envision RoboDrop becoming a useful tool to efficiently identify new synergistic antibiotic combinations toward combating AMR.

关键词： Droplet microfluidics Antimicrobial resistance Antibiotic combinatorial screening Contact printing Robotics pharmaceutical analysis High-throughput Antibiotic interactions

High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides with an 8-channel electrical titrator

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Chinese Chemical Letters 2018年第9期29卷 1391-1394页

作者： Xuzhi Zhang Qianqian Yang Xuchang Zhang Pingping Wang Zhihui Hao Jun Zhao Keming Qu Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao National Laboratory for Marine Science and Technology Department of Hematology Longgang District People’s Hospital School of Chemistry and pharmaceutical Sciences Qingdao Agriculture University

High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides were performed by employing an automatic 8-channel electrical titrator. Silver nitrate （AgNO3） and sodium tetraphenylborate （NaTPB） were used as titrants. When AgNO3 was used for measuring the drugs in pure form, recoveries were 97.6%-102.0% with RSD values ≤1.0%; for measuring them in pharmaceutical formulations, recoveries were 96.6%-99.1% with RSD values ≤1.0%. Batch samples of eight could be measured simultaneously and maximally 30 measurements per minute could be completed. When NaTPB was used for measuring the drugs in pure form, the recoveries were 96.8%-102.6% with RSD values 〈0.8%; for measuring them in pharmaceutical formulations, the recoveries were 97.5%-102.7% with RSD values ≤0.9%. For all analyses, no auxiliary devices or chemicals were needed and there was no requirement for changing or cleaning working electrodes between measurements. The efficiency, accuracy and precision of the proposed method make it an alternative for routine quality control analyses.

关键词： Eight-channel electrical titrator Ciprofloxacin hydrochloride Clomipramine hydrochloride Fexofenadine hydrochloride High throughput measurement pharmaceutical analysis

Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2120-2126页

作者： Shuai Guo Kening Li Yanwen Chen Bin Li State Key Laboratory of Natural Medicines and School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 210009China

Accurate localization of central nervous system(CNS)drug distribution in the brain is quite challenging to matrix-assisted laser desorption/ionization(MALDI)mass spectrometry imaging(MSI),owing to the ionization competition/suppression of highly abundant endogenous biomolecules and MALDI ***,we developed a highly efficient sample preparation technique,laser-assisted chemical transfer(LACT),to enhance the detection sensitivity of CNS drugs in brain tissues.A focused diode laser source transilluminated the tissue slide coated with α-cyano-4-hydroxycinnamic acid,an optimal matrix to highly absorb the laser radiation at 405 nm,and a very thin-layer chemical film mainly containing drug molecule was transferred to the acceptor glass ***,MALDI MSI was performed on the chemical film without additional sample *** major advantage of LACT is to minimize ionization competition/suppression from the tissue itself by removing abundant endogenous lipid and protein *** superior performance of LACT led to the successful visualization of regional distribution patterns of 16 CNS drugs in the mouse ***,the dynamic spatial changes of risperidone and its metabolite were visualized over a 24-h ***,the brain-to-plasma(B/P)ratio could be obtained according to MALDI MSI results,providing an alternative means to assess brain penetration in drug discovery.

关键词： pharmaceutical analysis Laser-assisted chemical transfer Mass spectrometry imaging Drug distribution Brain penetration

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4075-4097页

作者： Shilin Chen Zheng Li Sanyin Zhang Yuxin Zhou Xiaohe Xiao Pengdi Cui Binjie Xu Qinghe Zhao Shasha Kong Yuntao Dai Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China State Key Laboratory of Component Traditional Chinese Medicine College of Pharmaceutical Engineering of Traditional Chinese MedicineHaihe Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China China Military Institute of Chinese Medicine Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

pharmaceutical analysis is a discipline based on chemical, physical, biological, and information technologies. At present, biotechnological analysis is a short branch in pharmaceutical analysis;however, bioanalysis is the basis and an important part of medicine. Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety, which are important characteristics of drug quality. Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results, some biotechnological analysis methods have been gradually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis,including DNA super-barcoding, DNA-based rapid detection, multiplex ligation-dependent probe amplification, hyperspectral imaging combined with artificial intelligence, 3D biologically printed organoids,omics-based artificial intelligence, microfluidic chips, organ-on-a-chip, signal transduction pathwayrelated reporter gene assays, and the zebrafish thrombosis model. The applications of these emerging biotechniques in pharmaceutical analysis have been discussed in this review.

关键词： Biotechnology pharmaceutical analysis Rawmaterials Manufacturing control Quality analysis

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

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Science China Chemistry 2011年第5期54卷 812-815页

作者： LI QingNing WU XiaoJing ZHAO Juan WU ChangYu WANG XueMei State Key Laboratory of Bioelectronics Southeast University Nanjing 210096China Medical School Ningbo UniversityNingbo 315211China

In this study,we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore,this new nano-interface and Au-MCNT modified electrode could be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications.

关键词： pharmaceutical analysis electrochemical detection anticancer drugs gold nanoparticles multi-walled carbon nanotubes