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The Influence of HIF-1α Expression on Apoptosis and Number of T Lymphocyte in peyer’s patches after Burn with Delayed Fluid Resuscitation in Rats at Plateau

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surgical science 2016年第9期7卷 390-399页

作者： Cheng Zhang Yi Liu Ming Ma shifan Zhang Department of Burns and Plastic surgery Lanzhou General Hospital Lanzhou China Department of Thoracic surgery Lanzhou General Hospital Lanzhou China

Objective: To research the expression of hypoxia inducible factor-1 alpha (HIF-1 alpha) on the apoptosis and number of T lymphocyte in peyer’s patches after severe burn on plateau in rats. Methods: Wistar rats (n = 130) were subjected to deep thickness burn injury (30% TBsA, III degree), at two different altitudes. 60 of them were given delayed fluid resuscitation (DFR, n = 30 at each altitude) 6 h after burn at different altitude;60 of them were carried out immediate fluid resuscitation (IFR, n = 30 at each altitude);10 rats were subjected to 37°C warm water as sham burn (sG, n = 10). The peyer’s patches were harvested from the ileum of rats at different time point after burn respectively. The expression of HIF-1 alpha, CD3(+) and the apoptosis and number of T lymphocyte in peyer’s patches were detected by tissue microarray technology and immunohistochemistry. Results: The apoptosis was higher in DFR group than that in IFR group. The increase in HIF-1 alpha expression was observed mainly on cell nucleus in T lymphocytes. The expression levels of HIF-1 alpha in peyer’s patches were much higher in DFR group and IFR group than those in sG, and they were higher at high altitude (3848 metres) than those at lower altitude (1517 metres), and also higher in DFR group compared with IFR group (all P ssion levels of CD3sup>+sup> in peyer’s patches were much lower in DFR group and IFR group than those in sham group, and the lowest value appeared at 12 hours after burn (all P sion: High expression of HIF-1 alpha may induce the apoptosis of T lymphocytes in peyer’s patches after severe burn with delayed fluid resuscitation in rats at plateau.

关键词： Delayed Fluid Resuscitation peyer’s patches Apoptosis HIF-1α Burn Plateau

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Oral nanoparticles containing naringenin suppress atherosclerotic progression by targeting delivery to plaque macrophages

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Nano Research 2023年第1期16卷 925-937页

作者： Mengran Guo Zhongshan He Zhaohui Jin Lingjing Huang Jingmei Yuan shugang Qin Xinchun Wang Lili Cao Xiangrong song Department of Critical Care Medicine Department of Anesthesiology and Translational Neuroscience CenterDepartment of Clinical PharmacyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China First Affiliated Hospital of the Medical College Shihezi UniversityShihezi 832008China College of Medicine Chengdu UniversityChengdu 610000China

Atherosclerosis is the main cause of ischemic stroke and myocardial infarction *** have shown unique benefits for atherosclerosis treatment by targeting the lesional macrophages of ***,most of the nanocarriers are administered intravenously,which is inconvenient and may cause ***,we developed an oral lipid-polymer based nanoparticles(FA-LNPs)decorated with folic acid,which can not only effectively overcome intestinal mucosal-epithelial barrier by increasing the transmembrane transport through intestinal epithelial and the accumulation in peyer’s patches but also actively target to the aortic plaque sites and accumulate in lesional ***,naringenin(Nrg),one of the antiinflammation drugs,was designed to be the oral nanomedicine(FA-LNPs/Nrg)for the first time via the encapsulation of ***-LNPs/Nrg presented highly anti-atherosclerotic *** the atherosclerotic ApoE−/−mice were treated by FALNPs/Nrg via oral administration for three months,the aortic lesion area,plaque area,and necrotic core area of the aortic root were significantly ***,the lipid-related blood parameters recovered to normal *** study provides a promising approach to atherosclerosis treatment based on the novel oral targeting delivery system.

关键词： atherosclerosis macrophages peyer’s patches oral delivery folic acid naringenin

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self-assembled aggregations in Coptidis Rhizoma decoction dynamically regulate intestinal tissue permeability through peyer's patch-associated immunity

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Chinese Herbal Medicines 2021年第3期13卷 370-380页

作者： Qing-qing Zhang Ye Yang Rong-rong Ren Qing-qing Chen Jing-jing Wu Yu-yu Zheng Xiao-hui Hou Yu-feng Zhang Ming-song Xue Deng-ke Yin school of Pharmacy Anhui University of Chinese MedicineHefei 230012China Institute of Pharmaceutics Anhui Academy of Chinese MedicineHefei 230012China Engineering Technology Research Center of Modernized Pharmaceutics Education Office of Anhui ProvinceHefei 230012China state Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Objective:To investigate the dynamic regulation of self-assembled aggregations(sAA)in Coptidis Rhizoma decoction on the permeability of intestinal tissue and the mechanism ***:The effects of sAA on berberine(Ber)absorption were respectively analyzed in an in situ intestinal perfusion model and in an Ussing Chamber jejunum model with or without peyer’s patches(PPs).The expression levels of ZO-1,Occludin and Claudin-1 were detected by immunofluorescence to evaluate the tight junction(TJ)between intestinal epithelium *** expression levels of T-box-containing protein expressed in T cells,signal transducers and activators of tranion-6,retinoic acid receptor-related orphan receptor ct and forkhead box P3 in PPs were detected by the reverse transcription-polymerase chain reaction and the secretions of interferon-c(IFN-c),interleukin-4(IL-4),interleukin-17(IL-17)and transforming growth factor-b(TGF-b)in PPs were evaluated by immunohistochemistry,to reflect the differentiation of T lymphocyte in PPs to helper T(Th)cell 1,Th2,Th17 and regulatory T(Treg)*** confirm the correlation between sAA in Coptidis Rhizoma decoction,PPs-associated immunity and intestinal epithelium permeability,sAA were administrated on an Ussing Chamber jejunum model with immunosuppressed PPs and evaluated its influences on intestinal tissue permeability and TJ proteins ***:sAA in Coptidis Rhizoma decoction could dose-dependently promote Ber absorption in jejunum segment,with the participation of *** dose-dependent and dynamical regulations of sAA on permeability of intestinal tissue and TJ proteins expression level between intestinal epithelium cells occurred along with the dynamically changed T lymphocyte differentiation and immune effectors secretion in *** administration of sAA on immunosuppressed PPs exhibited dose-dependent PPs activation,inducing dynamic promotion on intestinal tissue permeability and inhibition on TJ proteins ***:

关键词： Coptidis Rhizoma decoction intestinal absorption intestinal mucosal immunity peyer’s patches self-assembled aggregations

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selected Aspects of Camel Immune system and Immune Responses

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Open Journal of Veterinary Medicine 2021年第6期11卷 177-211页

作者： saeed Y. Al Ramadan Kazem T. Al-Mohammed salem Ibrahim H. Alshubaith Ahmed M. Al-Ali salah Abohelaika Mohammed s. Moqbel Ahmed M. Alluwaimi Department of Anatomy College of Veterinary Medicine King Faisal University Al-Ahsaa Saudi Arabia Animal Resources Management Ministry of Environment Water and Agriculture Al-Ahsaa Saudi Arabia Environmental Health Department Al-Ahsaa Municipality Al-Ahsa Saudi Arabia Central Biotechnology Laboratory Veterinary Teaching Hospital College of Veterinary Medicine King Faisal University Al-Ahsaa Saudi Arabia Clinical Pharmacology Department Qatif Central Hospital Ministry of Health Saudi Arabia Department of Microbiology and Parasitology College of Veterinary Medicine King Faisal University Al-Ahsaa Saudi Arabia

The camel economy is of considerable importance for arid countries. In the last decade, studies about camel immune system and immune responses have recorded increasing interest. However, drawing a comprehensive pictur... 详细信息

The camel economy is of considerable importance for arid countriesspan>. In the last decade, studies about camel immune system and immune responses have recorded increasing interest. However, drawing a comprehensive picture of the camel immune system remains far from reached. A major part of this review is to cover the studies of the primary and secondary immune organs and the markers of the camel immune cells and certain lymphoid tissues. At the same time, immune responses to different diseases and the nature of effective immunity were included, with an emphasis on the most important zoonotic diseases in camels such as MERS CoV;brucellosis. New findings on the diversity mechanisms of camel immunoglobulin genes were addressed. However, detail of the mechanism of MHC-restricted cellular immunity and the mechanism of B lymphocyte activation in camels await further attention. Interestingly, the gross and the histological structure of the lymphoid tissues of the camel’s thymus, tonsils, and peyer’s patches have indicated significant differences from other animals in terms of structure and function. The most peculiar CD expression, such as LPAM-I, MAdCAM-1 and CX3CR1, in certain camel cells and tissues refers to possible extraordinary mechanisms of immune hemostasis in camel in span style="font-family:"">comparison to other ruminants. The widely applied immunodiagnostic techniques to control camel diseases and to assist in improving the camel resistance were considered. Extensive studies of the camel immune system were greatly hampered by lack of specific reagents to camel markers and low funds in the field of camel i

关键词： Camel CX3CR1 Heavy Chain Antibody MERs-CoV peyer’s patches

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