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Efficacy of a traditional persian medicine preparation for radiation-induced xerostomia:a randomized,open-label,active-controlled trial

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Journal of Integrative Medicine 2017年第3期15卷 201-208页

作者： Ghazaleh Heydarirad Hossein Rezaeizadeh Rasool Choopani Seyed Hamdollah Mosavat Ahmad Ameri Department of traditional Medicine School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran 15167-45811 Iran Department of traditional Medicine School of Traditional Medicine Tehran University of Medical Science Tehran 16687-53961 Iran Research Center for traditional Medicine and History of Medicine Shiraz University of Medical SciencesShiraz 71356-44144 Iran Essence of Parsiyan Wisdom Institute Traditional Medicine and Medicinal Plant Incubator Shiraz University of Medical Sciences Shiraz 71356-44144 Iran Department of Radiation Oncology Imam Hossein Hospital Shahid Beheshti University of Medical SciencesTehran 19946-15611 Iran

BACKGROUND： Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers （HNC）. However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE： Synthesizing the traditional use ofAIcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life （QOL） of HNC patients with radiation-induced xerostomia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect ofA. digitata and M. sy/vestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix （artificial saliva）. Patients were enrolled from the Imam Hossein Hospital＇s oncology clinic in Shahid Beheshti University of Medica Sciences. Tehran, Iran. MAIN OUTCOME MEASURES： Primary outcome measures in this trial were changes in patients＇ QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module （EORTC QLQ-H＆N 35）. RESULTS： Between-group analysis showed that the intervention group patients obtained significantly lower （better） total EORTC QLQ-H＆N 35 scores as compared to the control group at the end of the intervention period （P = 0.007）. Mean scores of dry mouth of EORTC QLQ-H＆N 35 was also significantly lower （better） in the intervention group as compared to the control group （P = 0.017）.

关键词： xerostomia medicine persian traditional hollyhocks common mallow cancer

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