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Immunoglobulin G4-related kidney disease involving the renal pelvis and perirenal fat:A case report

World Journal of Clinical Cases 2022年第8期10卷 2510-2515页

作者： Jun-Wei He Qian-Ming Zou Jun Pan Shu-Sheng Wang Song-Tao Xiang Department of Urology the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Immunoglobulin(Ig)G4-related disease(Ig G4-RD)is an autoimmune disease associated with chronic and progressive inflammation and *** is difficult to differentiate Ig G4-RD involving the kidney from infectious diseases and malignancy on *** SUMMARY We report the case of a 51-year-old Chinese man whose abdominal computed tomography scan showed diffuse bilateral enlargement of the kidneys and perirenal fat,thickening of the renal pelvic walls,and hydronephrosis of the right *** laboratory test results showed a serum creatinine level of 464μmol/*** patient was diagnosed with acute renal failure and was started on intermittent *** tests revealed high serum Ig G4 levels(20.8 g/L)and an enlarged right submaxillary lymph *** and histopathological examination of the enlarged node led to the diagnosis of Ig *** corticosteroid therapy,his serum creatinine level quickly decreased to near normal *** Ig G4-RD affecting the renal pelvis or perirenal fat is rare,with atypical imaging *** consultation is critical for accurate diagnosis and treatment of this *** cases should undergo biopsy to avoid misdiagnosis.

关键词： Immunoglobulin G4-related disease Renal pelvic perirenal fat Case report

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Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats

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The Journal of Biomedical Research 2012年第3期26卷 219-225页

作者： Yaping Wang Yan Song Meng Suo Xin Jin Gang Tian Department of Cardiology the First Affiliated Hospital of Medical CollegeXi'an Jiaotong UniversityXi'anShaanxi 710061China.

We sought to investigate the effects of telmisartan on high-fat diet-induced hypertension and to explore the possible underlying mechanisms. Rats receiving high-fat diet were randomly divided into two groups, the tel- misartan group （n = 9） and the high-fat diet group （n = 10）. The control group consisted of age-matched rats on a regular diet （n = 10）. At the end of the treatment, the body weight, blood pressure, insulin sensitivity and serum adiponectin levels of all rats were examined, and their visceral fat was extracted and weighed. Our results showed that telmisartan improved insulin resistance and dyslipidemia and increased serum adiponectin levels. Telmisar- tan also lowered both systolic blood pressure and diastolic blood pressure, and decreased the accumulation of perirenal fat associated with high-fat diet. Furthermore, telmisartan increased adiponectin mRNA expression in the perirenal fat. Correlation analysis showed that both systolic blood pressure and diastolic blood pressure were positively correlated with perirenal fat. These effects of telmisartan may be mediated through decreases in perirenal fat and contributed to the improvement of perirenal fat function. Our findings suggested a strong link between perirenal fat and high-fat diet-induced hypertension, and identified telmisartan as a potential drug for the treatment of obesity-related hypertension.

关键词： telmisartan high-fat diet hypertension perirenal fat adiponectin

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