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periplaneta americana extract promotes infectious diabetic ulcers wound healing by downregulation of LINC01133/SLAMF9

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Chinese Journal of Natural Medicines 2024年第7期22卷 608-618页

作者： YANG Yuhang HUANG Jun LI Xintian LIN Renjing WANG Xiaoyan XIAO Ge ZENG Juanni WANG Zhenquan Department of Anorectal Disease 1 The Second Affiliated Hospital of Hunan University of Traditional Chinese MedicineChangsha 410005China Department of Anorectal Disease 3 The Second Affiliated Hospital of Hunan University of Traditional Chinese MedicineChangsha 410005China Laboratory of Vascular Biology and Translational Medicine Medical SchoolHunan University of Chinese Medicine/Hunan Provincial Key Laboratory of Vascular Biology and Translational MedicineChangsha 410208China

Wound healing in diabetic ulcers remains a significant clinical challenge,primarily due to bacterial infection and impaired *** americana extract(PAE)has been widely used to treat diabetic wounds,yet its underlying mechanisms are not fully *** study aimed to elucidate these mechanisms by analyzing long non-coding RNA(lncRNA)expressions in the wound tissues from diabetic anal fistula patients treated with or without PAE,using high-throughput *** blood monocytes from patients were differentiated into M0 macrophages with human macrophage colony-stimulating factor(hMCSF)and subsequently polarized into M1 macrophages with *** results indicated that LINC01133 and SLAMF9 were downregulated in wound tissues of patients treated with ***,PAE suppressed M1 macrophage polarization and enhanced human umbilical vein endothelial cell(HUVEC)proliferation,migration,and *** effects were diminished when LINC01133 or SLAMF9 were ***,LINC01133 was shown to upregulate SLAMF9 through interaction with *** of SLAMF9 reversed the effects of LINC01133 silencing on macrophage polarization and HUVEC *** conclusion,PAE facilitates the healing of infected diabetic ulcers by downregulating the LINC01133/SLAMF9 pathway.

关键词： periplaneta americana extract Infectious diabetic ulcers M1 macrophage polarization LINC01133 SLAMF9

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periplaneta americana extract used in patients with systemic inflammatory response syndrome

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World Journal of Emergency Medicine 2016年第1期7卷 50-54页

作者： Hong-wei Zhang Li-you Wei Gang Zhao Ya-jing Yang Shu-zheng Liu Zhen-yu Zhang Zhang Jing Yan-ling Hu Department of Intensive Care Unit The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology) Tangshan 063000 China Department of Orthopedics The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology) Tangshan 063000 China Department of Clinical Laboratory The Second Hospital of Tangshan (Affiliated Orthopedic Hospital of North China University of Science and Technology) Tangshan 063000 China Department of Intensive Care Unit People's Hospital of Tangshan Tangshan 063001 China

BACKGROUND:periplaneta americana extract is recognized to have a positive effect on gastrointestinal *** study aimed to investigate the effects of periplaneta americana extract on immune function,nutrition status and gastrointestinal complications of early enteral nutrition patients with systemic inflammatory response syndrome(SIRS).METHODS:Patients with SIRS were randomly divided into two groups:treatment and control *** patients in the two groups received conventional therapy including enteral nutrition,but periplaneta americana extract,an additional Chinese medicine,was given to the patients in the treatment *** the beginning of treatment(0 day)and 1,3,and 7 days after treatment,the levels of immunoglobulin(Ig A),total lymphocyte count(TLC),total protein(TP)and prealbumin(PA)were respectively tested in patients'venous *** incidences of bloating,diarrhea,aspiration pneumonia and high blood sugar at 7 days after treatment were *** mortality of the patients in 28 days was ***:At 3 and 7 days after treatment,the levels of Ig A and TLC in the treatment group were higher than those in the control group(P0.05).CONCLUSION:periplaneta americana extract could reduce gastrointestinal complications and improve immune function and nutritional status in patients with systemic inflammatory response syndrome.

关键词： periplaneta americana extract Systemic inflammatory response syndrome Gastrointestinal function immune function Nutritional status Enteral nutrition

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Protective effect of periplaneta americana extract on intestinal mucosal barrier function in patients with sepsis

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Journal of Traditional Chinese Medicine 2013年第1期33卷 70-73页

作者： Hongwei Zhang Liyou Wei Zhenyu Zhang Shuzheng Liu Gang Zhao Jing Zhang Yanling Hu The Department of Intensive Care Unit The second Hospital of Tangshan The Department of Orthopaedics The second Hospital of Tangshan The Department of Intensive Care Unit People's Hospital of Tangshan

OBJECTIVE： To investigate the effect of the periplaneta americana extract on the intestinal mucosal barrier and prognostic implications in patients with sepsis. METHODS： Sixty and six patients with sepsis were assigned randomly to treatment group （32 cases） and control group （32 cases）. The extractfrom periplaneta americana plus conventional medication for sepsis was administered to the treatment group, while the control group only received conventional treatment. The gastrointestinal function scores and acute physiology and chronic health evaluation II （APACHE 11 ） scores of all subjects were documented at baseline, at days 1, 3 and 7 after treatment respectively and their blood endotoxin was tested at the same time points as well. The incidence of death was recorded for both groups throughout the trial. RESULTS： At days 3 and 7 after treatment, gastrointestinal function score, APACHE II, and endotoxin level in treatment group wasbetter than that in con- trol group and the difference between them was significant （both P〈0~05）. Although the incidence of death in treatment group was less than that in control group, the difference between the two groups was not significant （P〉 0.05）. CONCLUSION： The extract of periplaneta ameri- cana had protective effect on intestinal mucosal barrier and could improve the condition and prog- nosis in patients with sepsis.

关键词： periplaneta americana extract Sepsis APACHE Endotoxins Gastrointestinal diseases

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