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Diabetic foot ulcers: A devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities

引用

World Journal of Diabetes 2022年第12期13卷 1106-1121页

作者： Gamze Akkus Murat Sert Department of Endocrinology Cukurova UniversityAdana 33170Turkey Department of Internal Medicine Cukurova University Medical FacultyAdana 33170Turkey

Diabetic foot ulcer is a devastating complication of diabetes mellitus and significant cause of mortality and morbidity all over the world and can be complex and *** development of foot ulcer in a diabetic patient has been estimated to be 19%-34%through their *** pathophysiology of diabetic foot ulcer consist of neuropathy,trauma and,in many patients,additional peripheral arterial *** particular,diabetic neuropathy leads to foot deformity,callus formation,and insensitivity to trauma or *** standard algorithms in diabetic foot ulcer management include assessing the ulcer grade classification,surgical debridement,dressing to facilitate wound healing,offloading,vascular assessment(status and presence of a chance for interventional vascular correction),and infection and glycemic *** especially surgical procedures are sometimes inevitable,they are poor predictive factors for the prognosis of diabetic foot *** novel treatment modalities such as nonsurgical debridement agents,oxygen therapies,and negative pressure wound therapy,topical drugs,cellular bioproducts,human growth factors,energy-based therapies,and systematic therapies have been available for patients with diabetic foot ***,it is uncertain whether they are effective in terms of promoting wound healing related with a limited number of randomized controlled *** review aims at evaluating diabetic foot ulcer with regard to all *** will also focus on conventional and novel adjunctive therapy in diabetic foot management.

关键词： Diabetic foot ulcer peripheric artery disease Macrovascular complications Neuropathy Wagner classification Intralesionar growth factor treatment

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