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World Journal of Diabetes 2024年第6期15卷 1280-1290页

作者： Guang-An Li Jun Huang Li Fan Department of Echocardiography The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND peripheral vascular disease(PVD)is a common complication of type 2 diabetes mellitus(T2DM).Patients with T2DM have twice the risk of PVD as nondiabetic *** To evaluate left ventricular(LV)systolic function by layer-specific global longitudinal strain(GLS)and peak strain dispersion(PSD)in T2DM patients with and without *** Sixty-five T2DM patients without PVD,57 T2DM patients with PVD and 63 normal controls were enrolled in the ***-specific GLS[GLS of the epimyocardium(GLSepi),GLS of the middle myocardium(GLSmid)and GLS of the endocardium(GLSendo)]and PSD were *** operating characteristic(ROC)analysis was performed to calculate the sensitivity and specificity of LV systolic dysfunction in T2DM patients with *** calculated Pearson’s correlation coefficients between biochemical data,echocardiographic characteristics,and layer-specific GLS and *** There were significant differences in GLSepi,GLSmid and GLSendo between normal controls,T2DM patients without PVD and T2DM patients with PVD(PT2DM patients without PVD>T2DM patients with PVD in the absolute value of GLS(P<0.001).PSD differed significantly between the three groups,and the trend ranking was as follows:normal controls

关键词： Type 2 diabetes mellitus peripheral vascular disease Speckle tracking echocardiography Global longitudinal strain Peak strain dispersion

Gemcitabine-induced peripheral vascular disease and prolonged response in a patient with metastatic pancreatic adenocarcinoma:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1372-1378页

作者： Moinard-Butot Fabien Poprawa Elodie Schohn Anna Pietro Addeo Benabdelghani Meher Department of Medical Oncology Institut de Cancérologie Strasbourg EuropeStrasbourg 67200France Department of Supportive Care Institut de cancérologie Strasbourg EuropeStrasbourg 67200France Hepato-Pancreato-Biliary Surgery and Liver Transplantation Hôpitaux Universitaires de StrasbourgStrasbourg 67200France

BACKGROUND Gemcitabine is an antimetabolite used in the treatment of pancreatic *** of the side effects of gemcitabine is vascular ***,we report the case of a patient treated with gemcitabine who had peripheral vascular disease concomi-tant with a prolonged antitumor *** SUMMARY A 75-year-old man was diagnosed with locally recurrent pancreatic *** response was achieved after 9 mo of *** the same time,the patient reported peripheral vascular disease without *** was suspended,and after one month the Positron Emission Tomography(PET)scan showed locoregional tumor *** was resumed and partial response was obtained,but peripheral vascular disease *** Our results suggest that the appearance of peripheral vascular disease may be related to a prolonged response to gemcitabine.

关键词： Gemcitabine Pancreatic cancer peripheral vascular disease Prolonged tumor response Case report

Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis

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Chronic diseases and Translational Medicine 2017年第4期3卷 230-241页

作者： Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang Department of Epidemiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

UNASSIGNED:Several studies have investigated the association of angiotensin-converting enzyme () gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities.;UNASSIGNED:We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies. Random-effect models were applied to estimate the pooled odds ratio () with a 95% confidence interval (), regardless of between-study heterogeneity.;UNASSIGNED:A total of 13 studies with 1966 cases and 6129 controls were included in this meta-analysis. The pooled s for the association between I/D polymorphism and PVD risk were not statistically significant in the overall population under all genetic models. In further ethnicity-stratified analyses, we found a statistically significant association of I/D polymorphism with PVD susceptibility in Asians under most models. However, the association among Caucasians did not reach statistical significance.;UNASSIGNED:I/D polymorphism might be associated with susceptibility to PVD in the Asian population, but there was no clear evidence indicating a similar significant relationship among Caucasians.

关键词： Angiotensin-converting enzyme Insertion/deletion polymorphism Meta-analysis peripheral vascular disease

Is it necessary to stent renal artery stenosis patients before cardiopulmonary bypass procedures？

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Chinese Medical Journal 2011年第10期124卷 1453-1457页

作者： ZHENG Bin YAN Hong-bing LIU Rui-fang CHENG Shu-juan WANG Jian ZHAO Han-jun SONG Li Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Acute kidney injury （AKI） is associated with poor prognosis after cardiopulmonary bypass. The aim of this retrospective study was to investigate whether stent implantation before cardiopulmonary bypass has beneficial effect on development of AKI in renal artery stenosis （RAS） *** In this retrospective study, patients with abnormal baseline serum creatinine （SCr, 〉106 μmol/L） were not included. Included patients （n=69） were divided into two groups. Group 1 included 31 RAS patients receiving no stent implantation before cardiopulmonary bypass. Group 2 included 38 RAS patients having received stent implantation just before cardiopulmonary bypass. To assess AKI after cardiopulmonary bypass, serum urea nitrogen, SCr and creatinine clearance were recorded at baseline, at the end of operation, during the first and second postoperative 24 *** Baseline characteristics were similar between groups. Serum urea nitrogen, SCr, creatinine clearance before and after cardiopulmonary bypass were also similar class groups. Incidence of AKI in group 1 was not significantly different from group 2. In group 1, AKI defined by RIFLE between occurred in 7 （22.6%） patients： 5 （16.1%） with RIFLE-R,2 （6.5%） with RIFLE-I, and no patients with RIFLE-F. In group 2, 10 patients （26.3%） had an episode of AKI during hospitalization： 6 （15.8%） had RIFLE-R, 4 （10.5%） had RIFLE-I, and no patients had *** There are no data suggesting that it is necessary to stent RAS patients with normal SCr before cardiopulmonary bypass. However, it cannot be concluded that RAS is not associated with AKI after cardiopulmonary bypass

关键词： renal insufficiency cardiopulmonary bypass peripheral vascular disease renal artery

Lower Extremity Ulcers in Patients with Systemic Sclerosis

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Open Journal of Rheumatology and Autoimmune diseases 2022年第1期12卷 35-45页

作者： Marta B. Bean Chris T. Derk Department of Medicine University of Pennsylvania Philadelphia USA Division of Rheumatology Clinical Medicine University of Pennsylvania Philadelphia USA

Introduction: Cutaneous manifestations of systemic sclerosis (SSc) include skin ulceration;4% - 12% of patients with SSc develop lower extremity ulcers of various etiologies. Limited data, significant morbidity, and substantial cost of wound care led us to undertake this study to describe and identify risk factors. Methods: After Institutional Review Board approval, we identified 30 patients with SSc and lower extremity ulcers over a 10-year period at a single center with an SSc clinic, which were included in a descriptive analysis. Results: Median age of onset of lower extremity ulcers was 59.5 years (range 20 - 84). Ninety percent of patients were female, 60% were Caucasian, 63% had limited SSc, 13% diffuse SSc and 23% an overlap syndrome. Immunomodulators or steroids were prescribed in 53%;hypercoagulable state identified in 16%. Ulcers were attributed to venous stasis (27%), SSc (20%), trauma (20%), arterial disease (17%), and multifactorial/unknown (17%). In patients with ulcers attributed to SSc, age at onset was lower (45.5 vs 59.5 years). Biopsies generally did not contribute to management. Multidisciplinary treatment was routine;20% required amputation, 10% endovascular intervention, 20% frequent surgical debridement, 10% hyperbaric oxygen, 26% local treatment and antibiotics and 13% received immunosuppression for wound treatment. Conclusion: Lower extremity ulcers are a serious clinical problem in patients with SSc. The clinical exam, venous dopplers, ankle-brachial indices and assessment of vascular risk factors helped define causality. In younger patients, ulcers were more frequently attributed to SSc and these patients were more likely to be on immunosuppressants/DMARDS, possibly indicating severe phenotype of SSc.

关键词： Lower Extremity Ulcers Systemic Sclerosis Scleroderma peripheral vascular disease Venous Stasis

peripheral interventions and antiplatelet therapy: Role in current practice

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World Journal of Cardiology 2017年第7期9卷 583-593页

作者： Pahul Singh Yenal Harper Carrie S Oliphant Mohamed Morsy Michelle Skelton Raza Askari Rami N Khouzam Department of Medicine Division of Cardiovascular DiseasesUniversity of Tennessee Health Science Center Methodist University Hospital Department of Clinical Pharmacy University of Tennessee College of Pharmacy Department of Biology Emory University

peripheral arterial disease(PAD) is a common disorder associated with a high risk of cardiovascular mortality and continues to be under-recognized. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease. Management includes exercise program, pharmacologic therapy and revascularization including endovascular and surgical approach. The optimal revascularization strategy, endovascular or surgical intervention, is often debated due to the paucity of head to head randomized controlled studies. Despite significant advances in endovascular interventions resulting in increased utilization over surgical bypass, significant challenges still remain. Platelet activation and aggregation after percutaneous transluminal angioplasty of atherosclerotic arteries are important risk factors for re-occlusion/restenosis and life-threatening thrombosis following endovascular procedures. Antiplatelet agents are commonly prescribed to reduce the risk of myocardial infarction, stroke and death from cardiovascular causes in patients with PAD. Despite an abundance of data demonstrating efficacy of antiplatelet therapy in coronary artery disease and cerebrovascular disease, there is a paucity of clinical information, clinical guidelines and randomized controlled studies in the PAD population. Hence, data on antiplatelet therapy in coronary interventions is frequently extrapolated to peripheral interventions. The aim of this review article is to elucidate the current data on revascularization and the role and duration of antiplatelet and anticoagulant therapy in re-vascularized lower limb PAD patients.

关键词： peripheral arterial disease peripheral vascular disease Antiplatelet therapy Revascularization