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Changes in peripapillary retinal nerve fiber layer thickness in patients with primary open-angle glaucoma after deep sclerectomy

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World Journal of Ophthalmology 2011年第1期1卷 4-10页

作者： Asaad A Ghanem Salah M Mady Hatem El-Said El-wady Mansoura Oph-thalmic Center Faculty of Medicine Mansoura University 35516 Mansoura Egypt Department of Ophthalmology Benha Univer-sity 2465 Benha Egypt

AIM： To assess changes in peripapillary retinal nerve fiber layer （RNFL） thickness and visual field （VF） in patients with glaucoma after reduction of intraocular pressure （IOP）. METHODS： Thirty-five consecutive patients with bilat-eral high tension glaucoma were included in the study. Thirty-five eyes underwent monocular deep sclerectomy （surgery group） and the medically treated fellow eyes served as controls （control group）. Quantitative analyses of the peripapillary RNFL thickness by optical coherence tomography （OCT） and global VF indices by automated perimetry were performed before surgery and six months after surgery in both eyes. The changes in RNFL thickness overall and by quadrant were evalu-ated and studied with respect to age, best-corrected visual acuity （BCVA）, preoperative global VF indices, postoperative IOP changes, and postoperative changes in global VF indices. Changes observed in RNFL thickness and VF indices were compared between eyes after surgery and fellow eyes. RESULTS： Six months after surgery, the overall IOP decreased from a baseline mean of 24.5 ± 3.2 mmHg to 11.5 ± 2.7 mmHg （P 〈 0.001） at the time of OCT testing. A signifcant increase in the overall mean RNFL thickness was observed after surgery （P 〈 0.001）. The preoperative VF mean deviation was significantly cor-related with a postoperative increase in the RNFL thick-ness （P 〈 0.075）. No correlation was found between RNFL thickness changes and age, BCVA, or changes in the global VF indices. There was no significant difference between eyes with an IOP reduction of more than 50% and those with a reduction in IOP less than 30% （ P = 0.312）.CONCLUSION： A signifcant increase in the peripapil-lary RNFL thickness was associated with IOP reduction by glaucoma filtration surgery as measured by OCT.

关键词： peripapillary retinal nerve fiber layer thickness Optical coherence tomography Visual field indices Glaucoma medication Deep sclerectomy

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Optical coherence tomography evaluation of retinal nerve fiber layer thickness in non-arteritic anterior ischemic optic neuropathy and primary open angle glaucoma:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1370-1380页

作者： Yu-Xin Tong Xin-Yu Zhang Yi He Zong-Lin Chen Bing Jiang Department of Ophthalmology Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic Disease Changsha 410011Hunan ProvinceChina Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of General Surgery Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM:To assess the differences in average and sectoral peripapillary retinal nerve fiber layer(p RNFL)thickness using spectral domain optical coherence tomography(SD-OCT)in patients with non-arteritic anterior ischemic neuropathy(NAION)compared with those with primary open angle glaucoma(POAG).METHODS:A comprehensive literature search of the Pub Med,Cochrane Library,and Embase databases were performed prior to October,*** that compared the p RNFL thickness in NAION eyes with that in POAG eyes with matched mean deviation of the visual fields were *** weighted mean difference(WMD)with 95%confidence interval(CI)was used to pool continuous ***:Ten cross-sectional studies(11 datasets)comprising a total of 625 eyes(278 NAION eyes,347 POAG eyes)were included in the qualitative and quantitative *** pooled results demonstrated that the superior p RNFL was significantly thinner in NAION eyes than in POAG eyes(WMD=-6.40,95%CI:-12.22 to-0.58,P=0.031),whereas the inferior p RNFL was significant thinner in POAG eyes than in NAION eyes(WMD=11.10,95%CI:7.06 to 15.14,P≤0.001).No difference was noted concerning the average,nasal,and temporal p RNFL thickness(average:WMD=1.45,95%CI:-0.75 to 3.66,P=0.196;nasal:WMD=-2.12,95%CI:-4.43 to 0.19,P=0.072;temporal:WMD=-1.24,95%CI:-3.96 to 1.47,P=0.370).CONCLUSION:SD-OCT based evaluation of inferior and superior p RNFL thickness can be potentially utilized to differentiate NAION from POAG,and help to understand the different pathophysiological mechanisms between these two *** longitudinal studies and studies using eight-quadrant or clock-hour classification method are required to validate the obtained findings.

关键词： non-arteritic anterior ischemic optic neuropathy primar y open angle glaucoma optical coherence tomography peripapillary retinal nerve fiber layer thickness

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