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Ultrastructural Pathology of Nerve Cells in Mouse Brain Infected with Epidemic B Encephalitis Virus

Journal of Medical Colleges of PLA(China) 1989年第2期4卷 151-157页

作者：盛鹏晏良遂 Department of Pathology Third Military Medical CollegeChongqing

An animal model of epidemic(Japanese)B encephalitis was estabilisged by injecting theJin Wei Yah 1 stain of B encephalitis virus into the peritoneal cavity of *** ultrastructuralchanges of the nerve cells in their brains were studied,special attention being paid to some types ofnerve cell in the cerebellar *** infectet Purkinje cells and especially the granular cells showedspecial and inter,sting pathological *** were compared with the changes found in the in-fected nerve cells in the cerebral cortex,diencephalon and mesencephalon.A radiating structure consisting of a microveside-microtubule aggregation body at the centerand endoplastic reticulum or virus replication multivesicular structures around it was often found in thein fected nerve *** morphological features were described in detail,and its significance and the se-quenoe of events of its development *** the late stage of infection,virus particles were found in the nuclei of part of the *** is considered that they entered the nuclei from the cytoplasm during or after the death of theinfected *** observation smade in this study have comfimed in the granular cell of the cerebellum theidea of Chert et *** the encephalitis B virus particle can he formed in the perinudear cistem ofthe infected nerve cell,and have brought forth further information in this *** way of releaseof the virus particles from the infected nerve cells observed in this study is fundamentally consistentwith that observed by Chen et *** most of the virus particles left the nerve cell via the cell pro-

关键词： nerve cell ultrastructural pathology experimental B encephalitis mice virus replication perinuclear cistern radiating structure virus particles,necrotic cell nucleus

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Inflammatory bowel disease serology in Asia and the West

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World Journal of Gastroenterology 2013年第37期19卷 6207-6213页

作者： Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan Department of Gastroenterology St Vincent’s HospitalFitzroy 3065MelbourneAustralia Department of Medicine University of Melbourne Department of Medicine Imperial College Department of Gastroenterology Box Hill Hospital Department of Medicine and Therapeutics Chinese University of Hong Kong Inflammatory Bowel Disease Center Department of GastroenterologySourasky Medical Center

AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease ***:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient *** eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both *** CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD *** and titres of ALCA,ACCA and AMCA did not differ between CD in the two *** of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ***:Serologic CD responses differ between HK Asian and Australian Caucasian *** genetic,environmental or disease pathogenic factors may account for these differences.

关键词： Crohn’s disease Ulcerative colitis Serological antibodies Asia Ethnic Anti-Saccharomyces cervisiae antibodies Anti-chitobioside antibodies Antilaminaribioside antibodies Anti-mannobioside antibodies Atypical perinuclear anti-neutrophil cytoplasmic antibodies

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Isolated gastric Crohn's disease

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World Journal of Clinical Cases 2013年第2期1卷 71-73页

作者： Sachin B Ingle Chitra R Hinge Sarita Dakhure Smita S Bhosale Department of Pathology and Anaesthesia MIMSR Medical College

Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterized by segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine in about 30%. The stomach is rarely the sole or predominant site of CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. Isolated stomach involvement is very unusual presentation accounting for less than 0.07% of all gastrointestinal CD. The diagnosis is difficult to establish in cases of atypical presentation as in isolated gastroduodenal disease. In the absence of any other source of disease and in the presence of nonspecific upper GI endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent stud-ies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.

关键词： Gastrointestinal tract Crohn’s disease perinuclear anti-neutrophil cytoplasmic antibody Anti-Saccharomycescervisia antibody

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Crohn's disease with gastroduodenal involvement: Diagnostic approach

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World Journal of Clinical Cases 2015年第6期3卷 479-483页

作者： Sachin B Ingle Baban D Adgaonkar Nawab P Jamadar Saleha Siddiqui Chitra R Hinge Department of Pathology MIMSR Medical College Department of Physiology MIMSR Medical College Department of Anesthesia MIMSR Medical College

Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterizedby segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine is about 30%. Isolated involvement of stomach is an extremely unusual presentation of the disease accounting for less than 0.07% of all gastrointestinal CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. The diagnosis is difficult to establish in such cases with atypical presentation. In the absence of any other source of disease and in the presence of nonspecific upper gastrointestinal endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent studies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.

关键词： Gastrointestinal tract Crohn’s disease Isolated gastric involvement perinuclear anti-neutrophil cytoplasmic antibody Anti-Saccharomycescervisia antibody

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