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Recurrence in node-negative advanced gastric cancer:Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series

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World Journal of Gastroenterology 2017年第45期23卷 8000-8007页

作者： Gian Luca Baiocchi Sarah Molfino Carla Baronchelli Simone Giacopuzzi Daniele Marrelli Paolo Morgagni Maria Bencivenga Luca Saragoni Carla Vindigni Nazario Portolani Maristella Botticini Giovanni De Manzoni Department of Clinical and Experimental Sciences University of Brescia Department of Pathology Spedali Civili di Brescia 1st Department of General Surgery Borgo Trento HospitalUniversity of Verona Department of Human Pathology and Oncology Surgical OncologyUniversity of Siena Department of General Surgery Morgagni-Pierantoni Hospital Department of Pathology Morgagni-Pierantoni Hospital Department of Pathology Azienda Ospedaliera Universitaria Senese IGIER Università Bocconi

AIM To analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up. METHODS We enrolled 41 patients treated with curative gastrectomy for p T2-4 a N0 gastric carcinoma between 1992 and 2010,who developed recurrence(Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer,and compared them with 437 p T2-4 a N0 patients without recurrence(Group 2). We analyzed lymphatic embolization,microvascular infiltration,perineural infiltration,and immunohistochemical determination of p53,Ki67,and HER2 in Group 1 and in a subgroup of Group 2(Group 2 bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics. RESULTS T4 a stage and diffuse histotype were associated with recurrence in the group of p N0 patients. In-depth pathological analysis of two homogenous groups of p N0 patients,with and without recurrence during longterm follow-up(groups 1 and 2 bis),revealed two striking patterns: lymphatic embolization and perineural infiltration(two parameters that pathologists can easily report),and p53 and Ki67,represent significant factors for *** The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up.

关键词： N0 gastric cancer Recurrence Prognostic factors Pathological analysis Lymphatic embolization perineural infiltration p53 Ki67

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Current status of nerve infiltration by skip metastases in colorectal cancer

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Oncology and Translational Medicine 2024年第3期10卷 126-131页

作者： Jie Zhou Yan-Wei Gao Ya-Dong Ji Ri-Na Su Shuang Zhang Ze-He Li Inner Mongolia Medical University Hohhot 010000Inner MongoliaChina Abdominal Tumor Surgery Inner Mongolia Autonomous Region People’s HospitalHohhot 010017Inner MongoliaChina Baotou Medical College Baotou 014000Inner MongoliaChina Gastroenterology Department Arongqi People’s HospitalHulun Buir 021000Inner MongoliaChina

Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in *** China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 *** accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over *** infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of *** often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and *** symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with *** commonly include local pain,paresthesia,andmotor *** helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the *** of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted *** resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its *** cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor *** conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease *** detection and treatment are vital to improving prognosis.

关键词： Neve invasion in colorectal Skip metastases perineural infiltration

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