检索结果-南通市图书馆

perineural invasion as a prognostic factor in patients with stage Ⅰ-Ⅲ rectal cancer –5-year follow up

World Journal of Gastrointestinal Oncology 2020年第5期12卷 592-600页

作者： Milica Stojkovic Lalosevic Tamara Milovanovic Marjan Micev Mirjana Stojkovic Sanja Dragasevic Milos Stulic Ivan Rankovic Vladimir Dugalic Zoran Krivokapic Aleksandra Pavlovic Markovic Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaBelgrade 11000Serbia School of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Digestive Surgery-First Surgical Clinic Clinical Center of SerbiaBelgrade 11000Serbia

BACKGROUND Rectal cancer(RC)is one of the most common diagnosed cancers,and one of the major causes of cancer-related death *** of the current guidelines rely on TNM classification regarding therapy regiments,however recent studies suggest that additional histopathological findings could affect the disease *** To determine whether perineural invasion alone or in combination with lymphovascular invasion have an effect on 5-years overall survival(OS)of RC *** A prospective study included newly diagnosed stage I-III RC patients treated and followed at the Digestive Surgery Clinic,Clinical Center of Serbia,between the years of 2014–*** patients had their diagnosis histologically confirmed in accordance with both TMN and Dukes *** addition,the patient’s demographics,surgical details,postoperative pathological details,differentiation degree and their correlation with OS was *** Of 245 included patients with stage Ⅰ-Ⅲ RC,lymphovascular invasion(LVI)was identified in 92 patients(38%),whereas perineural invasion(PNI)was present in 46 patients(19%).Using Kaplan-Meier analysis for overall survival rate,we have found that both LVI and PNI were associated with lower survival rates(P<0.01).Moreover when Cox multiple regression model was used,LVI,PNI,older age,male gender were predictors of poor prognosis(HR=5.49;95%CI:2.889-10.429;P<0.05).CONCLUSION LVI and PNI were significant factors predicting worse prognosis in early and intermediate RC patients,hence more aggressive therapy should be reserved for these patients after curative resection.

关键词： Lymphovascular invasion perineural invasion Rectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

perineural invasion status, Gleason score and number of positive cores in biopsy pathology are predictors of positive surgical margin following laparoscopic radical prostatectomy

引用

Asian Journal of Andrology 2017年第4期19卷 468-472页

作者： Rong Yang Kai Cao Tao Han Yi-Feng Zhang Gu-Tian Zhang Lin-Feng XU Hui-Bo Lian Xiao-Gong Li Hong-Qian Guo Department of Urology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 China Department of Urology Nanjing Children's Hospital Nanjing 210008 China Department of Pathology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 China

This study was designed to define possible preoperative predictors of positive surgical margin after laparoscopic radical prostatectomy. We retrospectively analyzed the records of 296 patients with prostate cancer diagnosed by prostate biopsy, and eventually treated with laparoscopic radical prostatectomy. The prognostic impact of age, prostate volume, preoperative prostate-specific antigen, biopsy Gleason score, maximum percentage tumor per core, number of positive cores, biopsy perineurat invasion, capsule invasion on imaging, and tumor laterality on surgical margin was assessed. The overall positive surgical margin rate was 29.1%. Gleason score, number of positive cores, perineural invasion, tumor laterality in the biopsy specimen, and prostate volume significantly correlated with risk of positive surgical margin by univariate analysis （P 〈 0.05）. Gleason score （odds ratio [OR] = 2.286, 95% confidence interval [95% CI] = 1.431-3.653, P= 0.001）, perineural invasion （OR = 4.961, 95% CI = 2.656-9.270, P〈 0.001）, and number of positive cores （OR = 4.403, 95% CI = 1.878-10.325, P = 0.001） were independent predictors of positive surgical margin at the multivariable logistic regression analysis. Patients with perineural invasion, higher biopsy Gleason scores and/or a large number of positive cores in biopsy pathology had more possibility of capsule invasion. The positive surgical margin rate in patients with capsule invasion （49.5%） was much higher than that with localized disease （17.8%）. In contrast, prostate volume showed a protective effect against positive surgical margin （OR = 0.572, 95% CI = 0.346-0.945, P = 0.029）. Gleason score, perineural invasion, and number of positive cores in the biopsy specimen were preoperative independent predictors of positive surgical margin after laparoscopic radical prostatectomy while prostate volume was a protective factor against positive surgical margin.

关键词： needle biopsy perineural invasion positive surgical margin prostatectomy prostatic neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Midkine promotes perineural invasion in human pancreatic cancer

引用

World Journal of Gastroenterology 2014年第11期20卷 3018-3024页

作者： Jun Yao Wen-Yao Li Shuo-Guo Li Xiao-Shan Feng She-Gan Gao Department of Oncology First Affiliated HospitalHenan University of Science and Technology

AIM: To investigate midkine (MK) and syndecan-3 protein expression in pancreatic cancer by immunohistochemistry, and to analyze their correlation with clinicopathological features, perineural invasion, and prognosis.

关键词： Midkine Syndecan-3 Pancreatic cancer Neurite growth perineural invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Radiomics for predicting perineural invasion status in rectal cancer

引用

World Journal of Gastroenterology 2021年第33期27卷 5610-5621页

作者： Mou Li Yu-Mei Jin Yong-Chang Zhang Ya-Li Zhao Chen-Cui Huang Sheng-Mei Liu Bin Song Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Chengdu Seventh People’s HospitalChengdu 610213Sichuan ProvinceChina Department of Research Collaboration R&D CenterBeijing Deepwise&League of PHD Technology Co.LtdBeijing 100080China

BACKGROUND perineural invasion(PNI),as a key pathological feature of tumor spread,has emerged as an independent prognostic factor in patients with rectal cancer(RC).The preoperative stratification of RC patients according to PNI status is beneficial for individualized treatment and improved ***,the preoperative evaluation of PNI status is still *** To establish a radiomics model for evaluating PNI status preoperatively in RC *** This retrospective study enrolled 303 RC patients in a single institution from March 2018 to October *** patients were classified as the training cohort(n=242)and validation cohort(n=61)at a ratio of 8:2.A large number of intraand peritumoral radiomics features were extracted from portal venous phase images of computed tomography(CT).After deleting redundant features,we tested different feature selection(n=6)and machine-learning(n=14)methods to form 84 *** best performing classifier was then selected to establish ***,the clinicoradiological model(combined model)was developed by combining Rad-score with clinical *** models for predicting PNI were compared using receiver operating characteristic curve(ROC)analysis and area under the ROC curve(AUC).RESULTS One hundred and forty-four of the 303 patients were eventually found to be *** factors including CT-reported T stage(cT),N stage(cN),and carcinoembryonic antigen(CEA)level were independent risk factors for predicting PNI *** established Rad-score by logistic regression analysis after selecting features with the L1-based *** combined model was developed by combining Rad-score with cT,cN,and *** combined model showed good performance to predict PNI status,with an AUC of 0.828[95%confidence interval(CI):0.774-0.873]in the training cohort and 0.801(95%CI:0.679-0.892)in the validation *** comparison of the models,the combined model achieved a higher AUC than the clinic

关键词： Radiomics perineural invasion Rectal cancer Computed tomography Preoperative prediction Model building

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

perineural invasion in Pancreatic Cancer： Advanced Research in the Neuro-cancer Interactions

引用

Clinical oncology and cancer researeh 2010年第6期7卷 337-341页

作者： Xiao-hong SHEN Medical College of Nankai University Tianjin 300071. China.

Pancreatic Cancer （PCa） is characterized by prominently local nerve alterations and perineural invasion （PNI）, which frequently affects the extrapancreatic nerve plexus, causing severe pain and retropancreatic tumor extension. It precludes curative resection, promotes local recurrence, and at the last negatively influences the prognosis of patients. Recent research on PNI in PCa has revealed the critical involvement of numerous nerve- or cancer cell-derived molecules in vitro and in vivo. However, the mechanisms contributing to alteration and invasion of intrapancreatic nerves and the spread of cancer cells along extrapancreatic nerves in pancreatic cancer patients are still poorly understood. This review focuses on perineural invasion in pancreatic cancer and provides an outline of the characteristics and molecular mechanisms of perineural invasion in pancreatic cancer.

关键词： perineural invasion pancreatic cancer pancreatic neuropathy.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

引用

Cancer Communications 2021年第8期41卷 642-660页

作者： Jingbo Li Rui Kang Daolin Tang Department of Surgery UT Southwestern Medical CenterDallasTexas 75390USA

Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignant disease with a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous *** works have revealed that the dynamic interaction between cancer cells and neuronal cells leads to perineural invasion(PNI),a clinical pathological feature of *** formation and function of PNI are dually regulated by molecular(e.g.,involving neurotrophins,cytokines,chemokines,and neurotransmitters),metabolic(e.g.,serine metabolism),and cellular mechanisms(e.g.,involving Schwann cells,stromal cells,T cells,and macrophages).Such integrated mechanisms of PNI not only support tumor development,growth,invasion,and metastasis but also mediate the formation of pain,all of which are closely related to poor disease prognosis in *** review details the modulation,signaling pathways,detection,and clinical relevance of PNI and highlights the opportunities for further exploration that may benefit PDAC patients.

关键词： neurotrophins pancreatic ductal adenocarcinoma perineural invasion schwann cells tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

引用

World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan Liu Bai-Jin-Tao Sun Chuan Zhang Bing Li Xiao-Xuan Yu Yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer perineural invasion Magnetic resonance imaging Radiomics Nomogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

引用

BIOCELL 2024年第6期48卷 923-934页

作者： BINGJIE LI WENBO CAO JINJING XIAO YIXIAO CHEN QIYING WEI MINGJIN YUE SAIJUN MO Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouChina Collaborative Innovation Center of Henan Province for Cancer Chemoprevention ZhengzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment ZhengzhouChina Department of Research and Development Henan Tianxing Education and Media Company LimitedZhengzhouChina

perineural invasion(PNI),a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread,has the capacity to extend well beyond the primary tumor site,inﬁltrating distant regions devoid of lymphatic or vascular *** often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of *** its clinical signiﬁcance,the underlying molecular mechanisms of PNI remain elusive,complicating the development of speciﬁc and efﬁcacious diagnostic and therapeutic *** the realm of cancer research,non-coding RNAs(ncRNAs)have attracted considerable attention due to their multifaceted roles and cancer-speciﬁc expression proﬁles,positioning them as promising candidates for applications in cancer diagnostics,prognostics,and *** the various types of ncRNAs,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)have emerged as inﬂuential players in *** involvement is increasingly recognized as a contributing factor to tumor progression and therapeutic *** study synthesizes and explores the diverse functions and mechanisms of ncRNAs in relation to PNI in *** comprehensive review aims to shed light on cutting-edge perspectives that could pave the way for innovative diagnostic and therapeutic approaches to address the challenges posed by PNI in oncology.

关键词： perineural invasion Non-coding RNA Diagnose and treatment Cancer Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma

引用

World Journal of Gastrointestinal Oncology 2019年第12期11卷 1126-1140页

作者： Livia Petrusel Ioana Rusu Daniel Corneliu Leucuta Radu Seicean Ramona Suharoschi Paula Zamfir Andrada Seicean Department of Gastroenterology Regional Institute of Gastroenterology and HepatologyIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400162Romania Department of Pathology Regional Institute of Gastroenterology and HepatologyIuliu Hatieganu University of Medicine and Pharmacy Cluj-NapocaCluj-Napoca 400162Romania Medical Informatics and Biostatistics Department Iuliu Hatieganu University of Medicine and Pharmacy Cluj-NapocaCluj-Napoca 400012Romania First Surgery Clinic Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400006Romania Faculty of Food Science and Technology University of Agricultural Sciences and Veterinary Medicine Cluj-NapocaCluj-Napoca 400372Romania

BACKGROUND Cachexia is responsible for the low quality of life in pancreatic adenocarcinoma(PDAC).The rapid disease progression and patient deterioration seems related to perineural invasion,but the relationship between cachexia and perineural invasion for the evolution of the disease has been rarely *** perineural invasion is difficult to be highlighted,a biomarker such as the neurotrophic factor Midkine(MK)which promotes the neuronal differentiation and the cell migration could be ***,Activin(ACV)has been described as cachexia related to ***,their role for assessing and predicting the disease course in daily practice is not *** To assess the relationship between perineural invasion and cachexia and their biomarkers,MK and ACV,respectively,and their prognostic *** This study included prospectively enrolled patients with proven adenocarcinoma and a matched group of controls without any *** with other causes of malnutrition were *** plasma levels of ACV and MK were analyzed using western blotting and were correlated with the clinicopathological features and survival *** results were validated by immunohistochemical analyses of the pancreatic tumor tissue of the patients included in the study and a supplementary group of surgically resected specimens from patients with a benign *** The study comprised 114 patients with PDAC,125 controls and a supplementary group of 14 benign pancreatic tissue *** and MK were both overexpressed more frequently in the plasma of patients with PDAC than in the controls(63% vs 32% for ACV,Pperineural invasion(P=0.03)and diabetes(P=0.002),but with no influence on *** correlation between clinicopathological factors and ACV expression was ***

关键词： Pancreatic adenocarcinoma Cachexia perineural invasion Activin Midkine Biomarker Survival Metastases Endosonography Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer

引用

World Journal of Gastroenterology 2017年第40期23卷 7232-7241页

作者： Yan-Hui Yang Jiang-Bo Liu Yang Gui Liang-Liang Lei Shui-Jun Zhang Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou University Department of Hepatobiliary Surgery First Affiliated Hospital College of Clinical Medicine Henan University of Science and Technology Department of General Surgery First Affiliated Hospital College of Clinical Medicine Henan University of Science and Technology Henan Key Laboratory of Digestive Organ Transplantation Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities Zhengzhou Key Laboratory of Hepatobiliary Pancreatic Diseases and Organ Transplantation

AIM To investigate the relationship between autophagy and perineural invasion(PNI), clinical features, and prognosis in patients with pancreatic cancer. METHODS Clinical and pathological data were retrospectively collected from 109 patients with pancreatic ductal adenocarcinoma who underwent radical resection at the First Affiliated Hospital of Zhengzhou University from January 2011 to August 2016. Expression levels of the autophagy-related protein microtubuleassociated protein 1 A/1 B-light chain 3(LC3) and PNI marker ubiquitin carboxy-terminal hydrolase(UCH) in pancreatic cancer tissues were detected by immunohistochemistry. The correlations among LC3 expression, PNI, and clinical pathological features in pancreatic cancer were analyzed. The patients were followed for further survival analysis. RESULTS In 109 cases of pancreatic cancer, 68.8%(75/109) had evidence of PNI and 61.5%(67/109) had high LC3 expression. PNI was associated with lymph node metastasis, pancreatitis, and CA19-9 levels(P invasion(P invasion, whereas only neural invasion itself was an independent factor for high LC3 expression. Univariate analysis showed that LC3 expression, neural invasion, and CA19-9 level were related to the overall survival of pancreatic cancer patients(P invasion and LC3 expression are independent risk factors for pancreatic cancer with a poor prognosis.

关键词： Pancreatic cancer perineural invasion Autophagy Clinical pathological features Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：