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A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery

引用

Bioactive Materials 2022年第4期7卷 355-366页

作者： Dawei Jin Shuofei Yang Shuting Wu Meng Yin Haizhu Kuang Department of Cardiothoracic Surgery Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dong Fang RoadShanghai200127People’s Republic of China Department of Vascular Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong University160 Pujian RoadShanghai200127People’s Republic of China Department of Pharmacy The Third Affiliated Hospital(The Affiliated Luohu Hospital)of Shenzhen UniversityShenzhen518001Guangdong ProvincePeople’s Republic of China

pericardial barrier destruction,inflammatory cell infiltration,and fibrous tissue hyperplasia,trigger adhesions after cardiac *** are few anti-adhesion materials that are both functional and sutureable for pericardial ***,a few studies have reported on the mechanism of preventing pericardial ***,a functional barrier membrane with sutureability was developed via a modified electrospinning *** was composed of poly(L-lactide-co-caprolactone)(PLCL)nanofibers,poly(vinyl alcohol)(PVA)aerogel,and melatonin,named *** PPMT had a special microstructure manifested as a staggered arrangement of nanofibers on the surface and a layered macroporous aerogel structure in a *** providing the porosity and hydrophilicity obtained from PVA,the structure also had suitable mechanical properties for stitching due to the addition of PLCL ***,it inhibited the proliferation of fibroblasts by suppressing the activation of Fas and P53,and achieved anti-inflammatory effects by affecting the activity of inflammatory cells and reducing the release of pro-inflammatory factors,such as interleukin 8(IL-8)and tumor necrosis factorα(TNF-α).Finally,in vivo transplantation showed that it up-regulated the expression of matrix metalloproteinase-1(MMP1)and tissue inhibitor of metalloproteinase-1(TIMP1),and down-regulated the expression of Vinculin and transforming growth factorβ(TGF-β)in the myocardium,thereby reducing the formation of ***,these results demonstrate a great potential of PPMT membrane for practical application to anti-adhesion.

关键词： Anti-Adhesion PVA aerogel-Based membrane Sutureability Modified electrospinning technology pericardial reconstruction

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