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Cystic micropapillary neoplasm of peribiliary glands withconcomitant perihilar cholangiocarcinoma

World Journal of Gastroenterology 2016年第7期22卷 2391-2397页

作者： Tsuneyuki Uchida Yusuke Yamamoto Takaaki Ito Yukiyasu Okamura Teiichi Sugiura Katsuhiko Uesaka Yasuni Nakanuma Division of Hepato-Biliary-Pancreatic Surgery Shizuoka Cancer Center HospitalSunto-gunShizuoka 4118777Japan Division of Diagnostic Pathology Shizuoka Cancer Center HospitalSunto-gunShizuoka 4118777japan

We report a case of a 75-year-old man with cystic micropapillary neoplasm of peribiliary glands detected preoperatively by radiologic examination. Enhanced computed tomography showed a low-density mass 2.2 cm in diameter in the right hepatic hilum and a cystic lesion around the common hepatic duct. cholangiocarcinoma, right hepatectomy with caudate lobectomy and bile duct resection were performed. Pathological examination revealed perihilar cholangiocarcinoma mainly involving the right hepatic duct. The cystic lesion was multilocular and covered by columnar lining epithelia exhibiting increased proliferative activity and p53 nuclear expression; it also contained foci of micropapillary and glandular proliferation. Therefore, the lesion was diagnosed as a cystic micropapillary neoplasm of peribiliary glands and resembled flat branch-type intraductal papillary mucinous neoplasm of the pancreas. Histological examination showed the lesion was discontinuous with the perihilar cholangiocarcinoma. Immunohistochemistry showed the cystic neoplasm was strongly positive for MUC6 and that the cholangiocarcinoma was strongly positive for MUC5 AC and S100 P. These results suggest these two lesions have different origins. This case warrants further study on whether this type of neoplasm is associated with concomitant cholangiocarcinoma as observed in pancreatic intraductal papillary mucinous neoplasm with concomitant pancreatic duct adenocarcinoma.

关键词： Intraductal papillary neoplasm of thebile duct peribiliary gland Gastric type Perihilar cholangiocarcinoma

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Participation of peribiliary glands in biliary tract pathophysiologies

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World Journal of Hepatology 2013年第8期5卷 425-432页

作者： Saya Igarashi Yasunori Sato Xiang Shan Ren Kenichi Harada Motoko Sasaki Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine

AIM:To investigate the roles of peribiliary glands around the bile ducts in the pathophysiology of the biliary ***:The expression of fetal pancreatic markers,pancreatic duodenal homeobox factor 1(PDX1)and hairy and enhancer of split 1(HES1)and endodermal stem/progenitor(S/P)cell markers[CD44s,chemokine receptor type 4(CXCR4),SOX9 and epithelial cell adhesion molecule(EpCAM)]were examined immunohistochemically in 32 normal adult livers(autopsy livers)and 22 hepatolithiatic livers(surgically resected livers).The latter was characterized by the proliferation of the peribiliary *** was performed using formalin-fixed,paraffin-embedded tissue sections after *** PDX1and HES1 were expressed in both the nucleus and cytoplasm of epithelial cells,only nuclear staining was ***9 was expressed in the nucleus,while CD44s,CXCR4 and EpCAM were expressed in the cell *** frequency and extent of the expression of these molecules in the lining epithelia and peribiliary glands were evaluated semi-quantitatively based on the percentage of positive cells:0,1+(focal),2+(moderate)and 3+(extensive).RESULTS:In normal livers,PDX1 was infrequently expressed in the lining epithelia,but was frequently expressed in the peribiliary *** contrast,HES1was frequently expressed in the lining epithelia,but its expression in the peribiliary glands was focal,suggesting that the peribiliary glands retain the potential of differentiation toward the pancreas and the lining epithelia exhibit properties to inhibit such *** unique combination was also seen in hepatolithiatic *** expression of endodermal S/P cell markers varied in the peribiliary glands in normal livers:SOX9 and EpCAM were frequently expressed,CD44s infrequently,and CXCR4 almost not at *** expression of these markers,particularly CD44s and CXCR4,increased in the peribiliary glands and lining epithelia in hepatolithiatic *** increa

关键词： Biliary tree peribiliary glands Pancreatic duodenal homeobox factor 1 Stem cells Differentiation Pancreas

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Intra-hepatic and extra-hepatic cholangiocarcinoma:New insight into epidemiology and risk factors

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World Journal of Gastrointestinal Oncology 2010年第11期2卷 407-416页

作者： Vincenzo Cardinale Rossella Semeraro Alessia Torrice Manuela Gatto Cristina Napoli Maria Consiglia Bragazzi Raffaele Gentile Domenico Alvaro Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche Sapienza University of Rome00185 RomeItaly

Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary *** is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest that intra-hepatic CCA(IH-CCA) and EH-CCA are biologically different cancers,giving further support to a number of recent epidemiological studies showing large differences in terms of incidence,mortality and risk *** purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH-with EH-CCA.

关键词： Liver flukes Viral hepatitis Liver stem cells peribiliary glands Epidemiology Extra-hepatic cholangiocarcinoma Risk factors Primary sclerosing cholangitis Intra-hepatic cholangiocarcinoma Liver cirrhosis

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Pediatric intrahepatic bile duct adenoma-rare liver tumor: A case report

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World Journal of Gastrointestinal Surgery 2019年第11期11卷 414-421页

作者： Anup Kumar Roy Nrityen Nath Das Department of Surgery Downtown HospitalGuwahatiAssam 781006India Hepato-biliary and Liver Transplant Center Downtown HospitalGuwahatiAssam 781006India

BACKGROUND Intrahepatic bile duct adenoma(BDA)is one of the rarest of the rare benign tumors of the liver in the pediatric age *** arises from the epithelial lining of intrahepatic bile *** overall incidence of BDA is 1.3%of all primary benign liver *** case reports of this rare tumor occurring in adult population are present in the literature and to date,only one pediatric case has been reported *** SUMMARY An 18-month-old male child presented with chief complaints of mass per abdomen for 8 *** tomography abdomen revealed a well-defined exophytic solid tumor arising from the posteroinferior margin of the right lobe of the liver with heterogenous enhancement and cystic changes,suggesting a suspicion of ***-anatomical liver resection was done and a tumor of 10 cm×9.5 cm was *** of the specimen was conclusive with the diagnosis of intrahepatic bile duct adenoma,which was further supported by immunohistochemistry panel *** post-operative period was *** follow-up,the child was doing well and had no postoperative *** Intrahepatic bile duct adenoma in children is very rare and to date only one case has been *** is the second pediatric case of intrahepatic bile duct adenoma in the *** this is the first ever case of such a large tumor presenting in a child.

关键词： Bile duct adenoma peribiliary gland hamartoma Benign liver tumor Pediatric liver tumor Case report

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Multiple cells of origin in cholangiocarcinoma underlie biological,epidemiological and clinical heterogeneity

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 94-102页

作者： Vincenzo Cardinale Guido Carpino Lola Reid Eugenio Gaudio Domenico Alvaro Department of MedicoSurgical Sciences and Biotechnologies Polo PontinoSapienza University of Rome00137 RomeItaly Department of Health Sciences University of Rome "Foro Italico"000135 RomeItaly Department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of Rome000137 RomeItaly Department of Cell and Molecular Physiology Biomedical EngineeringProgram in Molecular Biology and BiotechnologyUNC School of MedicineChapel HillNC 27599United States Eleonora Lorillard Spencer-Cenci Foundation 00156 RomeItaly

Recent histological and molecular characterization of cholangiocarcinoma(CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological ***,different stem cell niches have been recently described in the liver and biliarytree,suggesting this as the basis of the heterogeneity of intrahepatic(IH)-and extrahepatic(EH)-CCAs,which are two largely different tumors from both biological and epidemiological points of *** complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver *** recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic,prognostic and,hopefully,therapeutic categories of IH-and EH-CCAs.

关键词： Intrahepatic cholangiocarcinoma Extrahepatic cholangiocarcinoma Cholangiocarcinoma classification Cholangiolocarcinoma Cells of origin Cancer stem cells peribiliary glands Biliary tree stem/progenitor cells Human hepatic stem cells Risk factors Targeted therapies

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