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Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance

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Bioactive Materials 2022年第10期7卷 359-371页

作者： Yumin Zhang Zujian Feng Jinjian Liu Hui Li Qi Su Jiamin Zhang Pingsheng Huang Weiwei Wang Jianfeng Liu Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciencesand Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300192PR China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Science and Peking Union Medical CollegeTianjin300192PR China

Radioresistance reduces the antitumor efficiency of radiotherapy and further restricts its clinical application,which is mainly caused by the aggravation of immunosuppressive tumor microenvironment(ITM).Especially tumor-associated macrophages(TAMs)usually display the tumor-promoting M2 phenotype during high-dose fractional radiotherapy mediating radiotherapy ***,the toll like receptor agonist TLR7/8a was conjugated with radiosensitive peptide hydrogel(Smac-TLR7/8 hydrogel)to regulate TAMs repolarization from M2 type into M1 type,thus modulating the ITM and overcoming the *** Smac-TLR7/8 hydrogel was fabricated through self-assembly with nanofibrous morphology,porous structure and excellent ***γ-ray radiation,Smac-TLR7/8 hydrogel effectively polarized the macrophages into M1 ***,combined with radiotherapy,TAMs repolarization regulated by Smac-TLR7/8 hydrogel could increase tumor necrosis factor secretion,activate antitumor immune response and effectively inhibit tumor ***,TAMs repolarization rebuilt the ITM and elicited the immunogenic phenotypes in solid tumors,thus enhanced the PD1-blockade efficacy through increasing tumor infiltrating lymphocytes(TILs)and decreasing Treg cells in two different immune activity tumor mice ***,this study substantiated that recruiting and repolarization of TAMs were critical in eliciting antitumor immune response and overcoming radioresistance,thus improving the efficacy of radiotherapy and immunotherapy.

关键词： Radioresistance Tumor-associated macrophage Polarization Immunosuppressive tumor microenvironment peptide hydrogel

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An amelogenin-based peptide hydrogel promoted the odontogenic differentiation of human dental pulp cells

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Regenerative Biomaterials 2022年第1期9卷 511-521页

作者： Xinxin Li Zhaoxia Yu Shihui Jiang Xiaohua Dai Guanhua Wang Yue Wang Zhimou Yang Jie Gao Huiru Zou State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction Tianjin Stomatological HospitalThe Affiliated Stomatological Hospital of Nankai UniversityTianjin 300041China School of Medicine Nankai UniversityTianjin 300071China

Amelogenin can induce odontogenic differentiation of human dental pulp cells(HDPCs),which has great potential and advantages in dentine-pulp complex ***,the unstability of amelogenin limits its further *** study constructed amelogenin self-assembling peptide hydrogels(L-gel or D-gel)by heating-cooling technique,investigated the effects of these hydrogels on the odontogenic differentiation of HDPCs and explored the underneath *** critical aggregation concentration,conformation,morphology,mechanical property and biological stability of the hydrogels were characterized,*** effects of the hydrogels on the odontogenic differentiation of HDPCs were evaluated via alkaline phosphatase activity measurement,quantitative reverse transcription polymerase chain reaction,western blot,Alizarin red staining and scanning electron *** mechanism was explored via signaling pathway *** showed that both the L-gel and D-gel stimulated the odontogenic differentiation of HDPCs on both Day 7 and Day 14,while the D-gel showed the highest enhancement ***,the D-gel promoted calcium accumulation and mineralized matrix deposition on Day *** D-gel activated MAPK-ERK1/2 pathways in HDPCs and induced the odontogenic differentiation via ERK1/2 and transforming growth factor/smad ***,our study demonstrated that the amelogenin peptide hydrogel stimulated the odontogenic differentiation and enhanced mineralization,which held big potential in the dentine-pulp complex regeneration.

关键词： amelogenin peptide hydrogel odontogenic differentiation human dental pulp cells

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Self-assembly Mechanism and Application of Environmental Responsive peptide hydrogel

Self-assembly Mechanism and Application of Environmental Res...

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第十届全国化学生物学学术会议

作者： Xiushuang Yuan Zhuqing Liu ShiZhong Luo Beijing key Laboratory of Bioprocess College of Life Science and Technology Beijing University of Chemical Technology

A novel environmental responsive peptide hydrogel, which exhibits response to pH and redox, was presented. In our study, a series of experiments were conducted to characterize the pH and redox response. The hydrogels were characterized by circular dichroism, rheology, TEM, atomic force microscopy, et al. Results confirm that electrostatic interactions between positive and negative charges are the driving forces for peptide self-assembly, as well as the changes in hydrophobicity of Methionine residues. With good self-healing effect, no cell toxicity, the peptide hydrogel has very promising developing potential and application value in drug delivery.

关键词： peptide hydrogel pH redox peptide self-assembly

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Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery

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Chinese Chemical Letters 2022年第4期33卷 1936-1940页

作者： Jie Li Zhongshi Wang Han Han Zhonghua Xu Shasha Li Ying Zhu Yuejian Chen Liang Ge Yuan Zhang Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqing 400038China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China School of Pharmacy Xinjiang Medical UniversityUrumqi 830054China Nanjing aifarui Pharmaceutical Technology Co. Ltd.Nanjing 210009China

Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide *** octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence.

关键词： peptide hydrogel pH Sensitivity Antitumor Drug delivery Targeted therapy

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hydrogel-supported poly(L-lactic acid) and polystyrene microsphere-based three-dimensional culture systems for in vitro cell expansion

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Frontiers of Materials Science 2024年第2期18卷 129-137页

作者： Huaying Hao Lihong Sun Jiaxuan Chen Jun Liang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China College of Light Industry Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China College of Food Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China

The in vitro expansion of stem cells is important for their application in different life science fields such as cellular tissue and organ *** objective of this paper was to achieve static cell culture in vitro through peptide hydrogel-supported microspheres(MSs).The peptides,with their gel-forming properties,microstructures,and mechanical strengths characterized,were found to have good support for the MSs and to be *** internal structures of poly(L-lactic acid)microspheres(PLLA-MSs)and polystyrene microspheres(PS-MSs)made in thelaboratory were observed and statistically analyzed in terms of particle size and pore size,following which the co-cultured MSs with cells were found to have good cell *** addition,three-dimensional(3D)culturing of cells was performed on the peptide and microcarrier composite scaffolds to measure cell viability and cell *** results showed that the peptides could be stimulated by the culture medium to self-assembly form a 3D fiber network *** the peptide-Ms composite scaffold-based cell culture system,further enhancement of the cell culture effect was *** peptide-Ms composite scaffolds have great potential for the application in 3D cell culture and in vitro cellexpansion.

关键词： microcarrier microsphere peptide hydrogel cell scaffold three-dimensional culture cell expansion

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peptide hydrogelation triggered by enzymatic induced pH switch

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 76-81页

作者： Wei Cheng Ying Li Nanjing Stomatological Hospital Medical School of Nanjing University Jiangsu Engineering Technology Research Centre of Environmental Cleaning Materials Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlJiangsu Joint Laboratory of Atmospheric Pollution ControlCollaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science &Technology National Laboratory of Solid State Microstructures Nanjing University

It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve hydrogels with optimal *** we report the hydrogelation of peptide hydrogelators by an enzymatically induced pH switch,which involves the combination of glucose oxidase and catalase with D-glucose as the substrate,in which both the gelation kinetics and thermodynamics can be controlled by the concentrations of *** novel hydrogelation method could result in hydrogels with higher mechanical stability and lower hydrogelation *** further illustrate the application of this hydrogelation method to differentiate different D-glucose levels.

关键词： glucose oxidase and catalase peptide hydrogel pH switch mechanical properties

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Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor

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Bio-Design and Manufacturing 2022年第1期5卷 153-162页

作者： Yafeng Jing Anhe Wang Jieling Li Qi Li Qingquan Han Xuefang Zheng Hongyu Cao Shuo Bai College of Life Science and Biotechnology DalianUniversityDalian 116622China State Key Laboratory of Biochemical Engineering Instituteof Process EngineeringChinese Academy of SciencesBeijing 100190China College of Environmental and Chemical Engineering DalianUniversityDalian 116622China

Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical properties similar to those of body ***,the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process *** overcome this issue,hydrophilic conductive polydopamine(PDA)-doped polypyrrole(PPy)nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel *** tech-nique creates a complete conductive network and allows visible light to pass *** strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency,but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection,as evidenced by the experimental data.

关键词： Conductivity Transparency peptide hydrogel Polypyrrole-polydopamine nanoparticles Wearable biosensor

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Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation

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Regenerative Biomaterials 2020年第1期7卷 99-107页

作者： Chen-Chen Zhao Lian Zhu Zheng Wu Rui Yang Na Xu Liang Liang Institute of Biology and Medicine College of Life Sciences and HealthWuhan University of Science and TechnologyWuhan 430081China The First College of Clinical Medical Science China Three Gorges University&Yichang Central People’s HospitalYichang 443003 China

Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the *** self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix,hydration environment and serving as drug delivery *** our study,resveratrol,a polyphenol compound with anti-inflammatory effect,is loaded into peptide-hydrogel(Fmoc-FFGGRGD)to form a wound dressing(Pep/RES).Resveratrol is slowly released from the hydrogel in situ,and the release amount is controlled by the loading *** in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of *** Pep/RES hydrogels are used as wound dressings in rat skin damage *** results suggest that the Pep/RES dressing can accelerate wound healing rate,exhibit well-organized collagen deposition,reduce inflammation and eventually prevent scar *** Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.

关键词： resveratrol peptide hydrogel wound healing inflammation

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Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells

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Regenerative Biomaterials 2021年第2期8卷 1-12页

作者： Ling Zhang Na Xiong Yanfei Liu Lili Gan Key Laboratory of Cell Engineering of Guizhou Province Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

In vivo,stem cells reside in a three-dimensional(3D)extracellular microenvironment in which complicated biophysical and biochemical factors regulate their *** of the stem cellmatrix interactions is an ideal approach for controlling the stem cell *** study investigates the effects of the incorporation of cell-adhesive ligands in 3D self-assembling peptide hydrogels to modulate stem cell survival,proliferation,maintenance of stemness,and osteogenic *** results show that the composite hydrogels were non-cytotoxic and effective for maintaining human amniotic mesenchymal stem cell(hAMSC)survival,proliferation and phenotypic *** expression levels of pluripotent markers were also upregulated in the composite *** inductive media conditions,mineral deposition and mRNA expression levels of osteogenic genes of hAMSCs were *** increasing expression of integrin aand b-subunits for hAMSCs indicates that the ligandintegrin interactions may modulate the cell fate for hAMSCs in composite hydrogels.

关键词： peptide hydrogel cell-adhesive ligand human amniotic mesenchymal stem cells stemness maintenance osteogenesis differentiation integrin

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peptide self‐assembly as a strategy for facile immobilization of redox enzymes on carbon electrodes

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Carbon Energy 2023年第11期5卷 15-30页

作者： Itzhak Grinberg Oren Ben‐Zvi Lihi Adler‐Abramovich Iftach Yacoby Department of Oral Biology The Goldschleger School of Dental MedicineFaculty of MedicineTel Aviv UniversityTel AvivIsrael The Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel AvivIsrael The Center for the Physics and Chemistry of Living Systems Tel Aviv UniversityTel AvivIsrael School of Plant Sciences and Food Security The George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Redox-enzyme‐mediated electrochemical processes such as hydrogen production,nitrogen fixation,and CO_(2) reduction are at the forefront of the green chemistry *** scale up,the inefficient two‐dimensional(2D)immobilization of redox enzymes on working electrodes must be replaced by an efficient dense 3D *** of 3D electrodes was demonstrated by embedding enzymes in polymer ***,several requirements,such as simple immobilization,prolonged stability,and resistance to enzyme leakage,still need to be *** study presented here aims to overcome these gaps by immobilizing enzymes in a supramolecular hydrogel formed by the self‐assembly of the peptide hydrogelator *** the self‐assembly process avoids the need for tedious and potentially harmful chemistry,allowing the rapid loading of enzymes on a 3D electrode under mild *** the[FeFe]hydrogenase enzyme,high enzyme loads,prolonged resistance against electrophoresis,and highly efficient hydrogen production are ***,this enzyme retention is shown to arise from its interaction with the peptide ***,this method is successfully used to retain other redox enzymes,paving the way for a variety of enzyme‐mediated electrochemical applications.

关键词： 3D electrode enzymes encapsulation H2 production hydrogenase peptide hydrogel

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