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Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor

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Journal of Pharmaceutical Analysis 2017年第5期7卷 324-331页

作者： Gema M.Durán Tomás E.Benavidez Ana M.Contento Angel Ríos Carlos D.García Department of Analytical Chemistry and Food Technology University of Castilla-La Mancha IRICA (Regional Institute of Applied Scientific Research) Department of Chemistry Clemson University219 Hunter Laboratories

A simple methodology was developed to quantify penicillamine(PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots(Cu-GQDs). The proposed strategy combines the advantages of carbon dots(over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response(in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.

关键词： Graphene quantum dots One-step synthesis Fluorescence quenching penicillamine Pharmaceutical preparations

penicillamine and auto-immunity:Relationship or coincidence?

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World Journal of Immunology 2017年第1期7卷 9-10页

作者： Sofia Santos Raquel Faria Department of Nephrology Centro Hospitalar do Porto Department of Medicine Centro Hospitalar do Porto

Drug induced lupus is an established and recognised entity,and penicillamine is one of the drugs that induce *** the uncertainty remains:Could penicillamine trigger autoimmunity in a broad-spectrum or in a particular ... 详细信息

关键词： penicillamine Auto-immunity Drug induced lupus

Clinical Efficacy and Safety of Chelation Treatment with Typical penicillamine in Cross Combination with DMPS Repeatedly for Wilson's Disease

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第5期33卷 743-747页

作者：徐三清李旭芳朱慧云刘艳方峰陈玲 Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Pediatrics Guangzhou Women and Children’s Medical Center

The aim of this study was to assess the clinical efficacy and safety of chelation treatment with penicillamine （PCA） in cross combination with sodium 2, 3-dimercapto-l-propane sulfonate （DMPS） repeatedly in patients with Wilson＇s disease （WD）. Thirty-five patients with WD were enrolled. They were administrated intravenous DMPS in cross combination with oral PCA alternately which was practiced repeatedly, all with Zinc in the meantime. During the treatment, clinical observations and 24-h urine copper excretion as well as adverse effects of medicines were recorded and analyzed. Although the incidence of adverse effects was not significantly different after either intravenous DMPS or oral PCA treatment, levels of 24-h urine copper tended to be higher after short-term intravenous DMPS than that of oral PCA. Adverse effects in the course of intravenous DMPS were mainly neutropenia, thrombocy- topenia, allergic reaction and bleeding tendency. As compared with oral PCA alone or intravenous DMPS alone, such repeated cross combination treatment could as much as possible avoid continued drug adverse effects or poor curative effect and had less chance to stop treatment in WD patients. Im- proved or recovered liver fimction in 71% of the patients, alleviated neurologic symptoms in 50% of the patients, and disappeared hematuria in 70% of the patients could be observed during the follow-up pe- riod of 6 months to 5 years after such combined chelation regimen. Chelation treatment repeatedly with oral penicillamine in cross combination with intravenous DMPS alternately could be more beneficial for WD patients to relieve symptoms, avoid continued drug adverse effects and maitain lifelong therapy.

关键词： Wilson's disease sodium 2, 3-dimercapto-l-propane sulfonate penicillamine efficacy adverse effects

Detection of Penicillin via Surface Plasmon Resonance Biosensor

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Chemical Research in Chinese Universities 2012年第5期28卷 792-796页

作者： ZHANG Ying JIN Wei YANG Meng-chao ZHANG Ti-qiang ZHOU Chao XIE Fei SONG Qi REN Hao JIN Qin-han MU Ying Research Center for Analytical Instrumentation Institute of Cyber-systems and ControlState Key Laboratory of Industrial Control TechnologyDepartment of Control Science and TechnologyZhejiang UniversityHangzhou 310058PR.China

A method of using Au colloid to capture the decomposed product of penicillin, penicillamine, on a surface plasmon resonance（SPR） biosensor for the quantitative determination of penicillin was developed. Based on the de-composition of penicillin to generate penicillamine and penilloaldehyde, a high sensitive biosensor for detecting penicillin was also developed. In our experiment, it was penicillamine rather than penicillin that has been measured. This is because penicillamine contains a functional group that makes it self-assembling on Au colloid to increase the molecular weight so as to improve the surface plasmon resonance signal. On a UV-Vis spectrophotometer, a high concentration of penicilliamine-Au complex was determined, indicating that penicillamine was already well combined with Au colloid. The method, using the combination of Au colloid with penicillamine, proved to detect penicillin.

关键词： Surface plasmon resonance(SPR) Biosensor penicillamine Au colloid

Liver transplantation in Wilson's disease: Single center experience from Saudi Arabia

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World Journal of Hepatology 2013年第3期5卷 127-132页

作者： Musthafa Chalikandy Peedikayil Hamad Ibrahim Al Ashgar Abdullah Al Mousa Mohammed Al Sebayel Khalid Al Kahtani Faisal Aba Alkhail Department of Medicine King Faisal Specialist Hospital and Research Center Liver Transplantation and Hepatobiliary Surgery King Faisal Specialist Hospital and Research Center

AIM: To determine liver transplantation outcomes in Wilson's disease (WD) patients, focusing on neurological manifestations. METHODS: This retrospective study assessed data from 16 WD patients (nine males, 56%) who had liver transplants between 1991 and 2007. Survival, graft function, and neurological complications were assessed during a follow-up period of up to 15 years. In addition, each patient's medical record was reviewed in detail to find the type of Wilson's disease (hepatic or hepatic plus neurological WD), indication for liver transplantation, use of chelating agents prior to transplantation, immediate and long term complications following transplantation, the donor details, and the pathology of explanted liver. RESULTS: End-stage liver disease was the indication for transplantation in all 16 WD patients. Four patients displayed WD-related neurological symptoms in addition to liver disease. Living-related liver transplantation was done in three cases. One patient died on postoperative day 6 due to primary graft non-function. Oneyear post liver transplant survival was 94%. Neurological manifestations of all four patients disappeared during their follow-up. Four patients developed acute cellular rejection, but all responded to treatment. One patient developed chronic ductopenic rejection after 15 years post-transplantation and their graft failed; this patient is currently waiting for re-transplantation. Fourteen patients (88%) are still living. The long-term average survival is currently 10.5 years, with a current median survival of 8 years. Long-term graft survival is currently 81%. CONCLUSION: Shortand long-term survival in WD patient liver transplantation was excellent, and neurological and psychological WD manifestations disappeared during long-term follow-up.

关键词： Wilson’s disease Liver transplantation Neurological Psychiatric penicillamine Saudi Arabia Transplantation

Wilson's disease: A review of what we have learned

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World Journal of Hepatology 2015年第29期7卷 2859-2870页

作者： Kryssia Isabel Rodriguez-Castro Francisco Javier Hevia-Urrutia Giacomo Carlo Sturniolo Gastroenterology and Endoscopy Policlinico Abano Terme35031 Abano TermePaduaItaly Gastroenterology Hospital San Juan de DiosApdo Postal 10138-1000San JoséCosta Rica Department of Surgery Oncology and GastroenterologyPadua University Hospital Hospital CIMA Apdo Postal 10201San JoséCosta Rica

Wilson's disease(WD), which results from the defective ATP7 B protein product, is characterized by impaired copper metabolism and its clinical consequences vary from an asymptomatic state to fulminant hepatic failure, chronic liver disease with or without cirrhosis, neurological, and psychiatric manifestations. A high grade of suspicion is warranted to not miss cases of WD, especially less florid cases with only mild elevation of transaminases, or isolated neuropsychiatric involvement. Screening in first and second relatives of index cases is mandatory, and treatment must commence upon establishment of diagnosis. Treatment strategies include chelators such as D-penicillamine and trientine, while zinc salts act as inductors of methallothioneins, which favor a negative copper balance and a reduction of free plasmatic copper. As an orphan disease, research is lacking in this field, especially regarding therapeutic strategies which are associated with better patient compliance and which could eventually also reverse established injury.

关键词： Wilson's disease Wilson disease Chelatingagents penicillamine Zinc Copper Orphan disease Liver transplantation