检索结果-南通市图书馆

CDS:A Fold-change Based Statistical Test for Concomitant Identification of Distinctness and Similarity in Gene Expression Analysis

引用

Genomics,Proteomics & Bioinformatics 2012年第3期10卷 127-135页

作者： Nicolas Tchitchek José Felipe Golib Dzib Brice Targat Sebastian Noth Arndt Benecke Annick Lesne Institut des Hautes Etudes Scientifiques Bures-sur-Yvette 91440France Centre National de la Recherche Scientifique USR3078Bures-sur-Yvette 91440France Laboratoire de Physique Théorique de la Matière Condensée CNRS UMR7600Université Pierre et Marie Curie-Paris 6Paris 75005France

The problem of identifying differential activity such as in gene expression is a major defeat in biostatistics and *** important,however much less frequently studied,is the question of similar activity from one biological condition to *** foldchange,or ratio,is usually considered a relevant criterion for stating difference and similarity between ***,no statistical method for concomitant evaluation of similarity and distinctness currently exists for biological *** microarray,digital PCR(dPCR),and Next-Generation Sequencing(NGS) technologies frequently provide a means of coefficient of variation estimation for individual *** fold-change,and by making the assumption that measurements are normally distributed with known variances,we designed a novel statistical test that allows us to detect concomitantly,thus using the same formalism,differentially and similarly expressed genes(http://***).Given two sets of gene measurements in different biological conditions,the probabilities of making type I and type II errors in stating that a gene is differentially or similarly expressed from one condition to the other can be ***,a confidence interval for the fold-change can be ***,we demonstrate that the assumption of normality can be relaxed to consider arbitrary distributions *** Concomitant evaluation of Distinctness and Similarity(CDS) statistical test correctly estimates similarities and differences between measurements of gene *** implementation,being time and memory efficient,allows the use of the CDS test in high-throughput data analysis such as microarray,dPCR,and NGS ***,the CDS test can be applied to the comparison of single measurements(N:1) provided the variance(or coefficient of variation) of the signals is known,making CDS a valuable tool also in biomedical analysis where typically a single measurement per

关键词： Statistical test Fold-change Distinctness Similarity Gene expression Single measurement patient study

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：