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Virus load and virus shedding of SARS-CoV-2 and their impact onpatient outcomes

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World Journal of Clinical Cases 2020年第24期8卷 6252-6263页

作者： Pei-Fen Chen Xia-Xia Yu Yi-Peng Liu Di Ren Min Shen Bing-Sheng Huang Jun-Ling Gao heng-Yang Huang Ming Wu Wei-Yan Wang Li Chen Xia Shi Zhao-Qing Wang Ying-Xia Liu Lei Liu Yong Liu Department of Respiratory Diseases Shenzhen Key Laboratory of Pathogen and ImmunityNational Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseasesShenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Expert Panel of Shenzhen 2019-nCoV Pneumonia The Second People’s Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseasesShenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina Medical AI Laboratory School of Biomedical EngineeringHealth Science CentreShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Buddhism and Science Research Laboratory Centre of Buddhist StudiesThe University of Hong KongPokfulamHong Kong 999077China ICU The Second People's Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Expert Panel of Shenzhen 2019-nCoV Pneumonia Shenzhen HospitalSouthern Medical UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND Understanding a virus shedding patterns in body fluids/secretions is importantto determine the samples to be used for diagnosis and to formulate infectioncontrol *** To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)shedding patterns and its risk *** All laboratory-confirmed coronavirus disease 2019 patients with completemedical records admitted to the Shenzhen Third People’s Hospital from January28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males;median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid(BALF) had the highest virus load compared with the other samples. The viralload peaked at admission (3.3 × 108 copies) and sharply decreased 10 d *** The viral load was associated with prolonged intensive care unit (ICU) *** in the ICU had significantly longer shedding time compared to those inthe wards (P 60 years [hazard ratio (HR) = 0.6;95% confidenceinterval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding,while chloroquine (HR = 22.8;95%CI: 2.3-224.6) was a protective *** BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads,which was associated with a prolonged ICU stay. Chloroquine was associatedwith shorter shedding duration and increased the chance of viral negativity.

关键词： COVID-19 Virus shedding Viral load patient outcome China Infectious disease

A risk score system for stratifying the risk of relapse in B cell acute lymphocytic leukemia patients after allogenic stem cell transplantation

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Chinese Medical Journal 2021年第10期134卷 1199-1208页

作者： Le-Qing Cao Yang Zhou Yan-Rong Liu Lan-Ping Xu Xiao-Hui Zhang Yu Wang Huan Chen Yu-Hong Chen Feng-Rong Wang Wei Han Yu-Qian Sun Chen-Hua Yan Fei-Fei Tang Xiao-Dong Mo Kai-Yan Liu Qiao-Zhen Fan Ying-Jun Chang Xiao-Jun Huang Peking University People’s Hospital&Peking University Institute of Hematology National Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences2019RU029BeijingChina

Background:For patients with B cell acute lymphocytic leukemia(B-ALL)who underwent allogeneic stem cell transplantation(allo-SCT),many variables have been demonstrated to be associated with leukemia *** this study,we attempted to establish a risk score system to predict transplant outcomes more precisely in patients with B-ALL after ***:A total of 477 patients with B-ALL who underwent allo-SCT at Peking University People’s Hospital from December 2010 to December 2015 were enrolled in this retrospective *** aimed to evaluate the factors associated with transplant outcomes after allo-SCT,and establish a risk score to identify patients with different probabilities of *** univariate and multivariate analyses were performed with the Cox proportional hazards model with time-dependent ***:All patients achieved neutrophil engraftment,and 95.4%of patients achieved platelet *** 5-year cumulative incidence of relapse(CIR),overall survival(OS),leukemia-free survival(LFS),and non-relapse mortality were 20.7%,70.4%,65.6%,and 13.9%,*** analysis showed that patients with positive post-transplantation minimal residual disease(MRD),transplanted beyond the first complete remission(≥CR2),and without chronic graft-versus-host disease(cGVHD)had higher CIR(Ppatients without MRD after transplantation,transplanted in CR1,and with cGVHD.A risk score for predicting relapse was formulated with the three above *** 5-year relapse rates were 6.3%,16.6%,55.9%,and 81.8%for patients with scores of 0,1,2,and 3(Ppatients with different risks of relapse,which could guide treatment.

关键词： B cell acute lymphocytic leukemia Allogeneic stem cell transplantation Minimal residual disease Disease status chronic graft-versus host disease patient outcome

Evaluation of Intraoperative Iatrogenic Lesions and Postoperative Complications in 1140 patients Treated for Carpal Tunnel Syndrome in the Orthopedic Surgery and Traumatology Department of the Moulins-Yzeure Hospital Center in France

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Surgical Science 2023年第12期14卷 705-711页

作者： Saint Luc Mungina Sedou Charlène Tshitala Jean-François Dumez Issifou Moumouni Kevin Ndangi Kibadi Kapay Department of Surgery of the University Clinics of Kinshasa Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Matete General Reference Hospital Kinshasa Democratic Republic of the Congo Department of Orthopedic Surgery and Traumatology Moulins-Yzeure Hospital Center Moulins France

Introduction: Carpal tunnel syndrome is a more common form of upper limb canal syndrome, resulting from compression of the median nerve in the carpal tunnel, but is particularly troublesome. Medical treatment is often unsuccessful, and surgical treatment usually involves transection of the annular ligament. The aim of this study was to assess iatrogenic intraoperative and postoperative complications, as well as patient outcomes following the use of conventional and endoscopic surgery in the surgical management of carpal tunnel syndrome. Hypothesis: Are nerve, vascular and tendon injuries of iatrogenic origin always present in the surgical management of carpal tunnel syndrome, even though this surgery is performed on an outpatient basis? patients and methods: This retrospective series is composed of 1140 patients, 230 men and 910 women, mean age 58.6 ± 16.4 years, operated on between 2010 and 2020 for carpal tunnel syndrome by conventional surgery and under endoscopy. Medical records, operative reports and consultation letters were consulted. All patients were reviewed regularly at one month post-op until recovery. Results: No nerve, vascular or tendon damage was noted, and at a maximum follow-up of 2 years, 20 patients had recurred, i.e. a 2.51% failure rate. Scar disunion was observed in 0.9%, wound infection in 0.9% and scar fibrosis in 0.9%. 92.98% of patients underwent outpatient surgery, irrespective of the type of anesthesia or surgical technique used. patients who stayed in hospital for a short time were suffering from carpal tunnel syndrome associated with compression of the ulnar nerve in Guyon’s canal, for which both the median and ulnar nerves were freed during the same operation, under general anaesthetic. All patients were able to return to their previous activity within 30 days of surgery. Conclusion: Intraoperative iatrogenic complications, notably nerve, vascular and tendon lesions, were not identified despite the large sample size. On the other hand

关键词： Carpal Tunnel Iatrogenic Complications patient outcome Surgical Treatment

Management of Penetrating Cranioencephalic Trauma Caused by Sharp Metal Objects—Therapeutic and Evolutionary Aspects: 12 Cases at the Renaissance University Hospital in N’Djamena

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Open Journal of Modern Neurosurgery 2024年第2期14卷 170-178页

作者： Goumantar Félicien Toudjingar Li-Iyane Olivier Ouambi Yannick Canton Kessely Donal Djasdé Mahouli Fata Vounki Momar Codé Ba Neurosurgery Unit of Center Hospitalier Universitaire la Renaissance N&#8217Djamena Chad Neurosurgery Unit of CHU la Ré f&#233rence Nationale N&#8217Djamena Chad Neurosurgery Department of Centre Hospitalier National Universitaire de Fann Dakar Senegal

Introduction: Cranioencephalic trauma caused by bladed weapons is rare, and that caused by sharp objects is exceptional. The aim of our study was to describe the clinical, therapeutic and evolutionary aspects. Materials and method: This was a descriptive and analytical study over a 48-month period at CHU la Renaissance from January 1, 2018 to December 31, 2021, concerning patients admitted for penetrating cranioencephalic trauma by pointed object. Results: Twelve cases, all male, of penetrating cranioencephalic sharp-force trauma were identified. The mean age was 34 ± 7 years, with extremes of 11 and 60 years. Farmers and herders accounted for 31% and 25% of cases respectively. The average admission time was 47 hours. Brawls were the circumstances of occurrence in 81.2% of cases. Knives (33%), arrows (25%) and iron bars (16.6%) were the objects used. Altered consciousness was present in 43.8% of cases, and focal deficit in 50%. Scannographic lesions were fracture and/or embarrhment (12 cases), intra-parenchymal haematomas (6 cases) and presence of object in place (4 cases). Surgery was performed in 11 patients. Postoperative outcome was favorable in 9 patients. After 12 months, 2 patients were declared unfit. Conclusion: Penetrating head injuries caused by sharp objects are common in Chad. Urgent surgery can prevent disabling after-effects.

关键词： Penetrating Trauma Skull Encephalon Sharp Object Surgery patient outcome