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The application of corticosteroids for pathological scar prevention and treatment:current review and update

Burns & Trauma 2023年第1期11卷 314-324页

作者： Meiying Sheng Yunsheng Chen Hua Li Yixin Zhang Zheng Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong University639 Zhizaoju RdShanghai 200011P.R.China Department of Burns and Plastic Surgery Shanghai Institute of Burns ResearchRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

The prevention and treatment of pathological scars remain *** are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar pruritus and ***,intralesional injections of corticosteroids are widely used in clinical *** require professional medical manipulation;however,the significant accompanying injection pain,repetition of injections and adverse effects,such as skin atrophy,skin pigmentation and telangiectasia,make this treatment modality an unpleasant experience for *** administration is,therefore,a promising non-invasive and easy-to-use method for corticosteroid administration for scar *** this review,we first summarize the mechanisms of action of corticosteroids in scar prevention and treatment;then,we discuss current developments in intralesional injections and the progress of transdermal delivery systems of corticosteroids,as well as their corresponding advantages and disadvantages.

关键词： Corticosteroids pathological scar Prevention and treatment Transdermal drug delivery Administration method

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Implantation Instrument on the Expression of Collagen-I and Cell Proliferation Markers in pathological scar

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Chinese Journal of Plastic and Reconstructive Surgery 2019年第2期1卷 16-20页

作者： Meng WANG Gang ZHANG Wen-guang ZHANG Qian HUANG Wan-hong CHEN Cheng WANG Shenzhen Longhua People’s Hospital Guangdong Province518109China The Fifth Affiliated Hospital of Zunyi Medical University Guangdong Province519100China Affiliated Hospital of Guangdong Medical University Guangdong Province524001China

Objective To explore the efficacyof scar Infusion Instrument on expression of Type I Collagen and Cell Proliferation Markers in pathological *** 70 cases patients with pathologic scar admitted in our hospital from Augst 2016 to July 2017 were randomly divided into study group and control *** control group was treated with scar *** treatment group was treated with scar ointment combined with scar The expression of COL-I in scar tissue was determined by enzyme-linked immunosorbent assay(ELISA).The expression of ki-67 nuclear protein was determined by immunohistochemical staining(sp).Results The efficacy of the study group was significantly better than the control group,the total efficiency of the study group was significantly higher than the control group after 6 months treatment(Pscarring device is more effective in the treatment of pathological scar,and its mechanism may be related to the better inhibition of COL-I and ki-67 nucleoprotein expression.

关键词： scarring instrumental pathological scar COL-I ki-67 nucleopro tein

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Using Zhang’s supertension-relieving suture technique with slowly-absorbable barbed sutures in the management of pathological scars:a multicenter retrospective study

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Burns & Trauma 2023年第1期11卷 550-559页

作者： Peiru Min Shunuo Zhang Dorsa Gholamali Sinaki Ping Yao Fuhua Hu Xin Wang Danya Zhou Jun Chai Yixin Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine639 ZhiZaoJu RoadHuangpu DistrictShanghai200011China Department of Plastic Surgery Hangzhou Plastic Surgery Hospital168 Shangtang RoadXiacheng DistrictHangzhou310000ZhejiangChina Department of Plastic and Reconstructive Surgery Ningbo Sixth Hospital1059 East Zhongshan RoadYinzhou DistrictNingbo315040ZhejiangChina Department of Burns and Plastic Surgery Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine197 RuiJinEr RoadHuangpu DistrictShanghai200020China

Background:An ideal tension-relieving suture should be efficient for>3 months to retrieve normal tensile *** preexisting suturing techniques provided tension elimination followed by relapse and scar proliferation due to absorption and cut-through of the *** study introduces a simple but effective suture technique developed by a senior author(ZYX)to solve this ***:A total of 120 patients with pathological scar(PS)had intervention treatment with the proposed suturing strategy at three centers from January 2018 to January 2021.A slowly absorbable 2-0 barbed suturewas used for subcutaneous tension relieving with a set-back from the wound edge and a horizontal interval between proposed inserting points of 1 *** Patient and Observer scar Assessment Scale(POSAS),scar width,perfusion and eversion of the wound edge were evaluated at 3-,6-and 12-month *** time needed to place the tension-relieving suture was recorded and relapse was monitored for 18 months ***:In total,76 trunks,32 extremities and 12 cervical PS were included,with an average subcutaneous tension-relieving suture time of 5 *** Patient and Observer scar Assessment Scale(POSAS)score decreased from 84.70±7.06 preoperatively to 28.83±3.09,26.14±1.92 and 24.71±2.00 at 3,6 and 12 months postoperatively,respectively(pscar widths were 0.17±0.08,0.25±0.09 and 0.33±0.10 cm,respectively,with perfusion significantly decreased from 213.64±14.97 to 112.23±8.18 at 6 months(pscar ***:Zhang’s suture technique provides a rapid and long-lasting tension-relieving effect with ideal scar appearances and lower relapse rates in the surgical management of PS.

关键词： pathological scar Tension-relieving Suture technique Tension

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Discussion on the mechanism of Salvia miltiorrhiza in treating pathological scars based on network pharmacology

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Journal of Chinese Pharmaceutical Sciences 2021年第10期30卷 813-821页

作者： Hongzhuang Zhang Zhiwei Yang Jianghe Zhang Yiming Zhang Shike Hou Zhenguo Wang Li Yan Dongli Fan The Second Affiliated Hospital of Army Military Medical University Chongqing 400037China Featured Medical Center of Chinese People's Armed Police Forces Tianjin 300162China

In the present study, we aimed to explore the mechanism of Salvia miltiorrhiza in the treatment of pathological scars(PS) by network pharmacology. The active ingredients and drug targets of Salvia miltiorrhiza were screened out through TCMSP database, the disease targets of PS in Gene Cards database were obtained, and Venn diagram analysis on drug targets and disease targets was performed, and the intersection was used as the target of Salvia miltiorrhiza for the treatment of PS. Cytoscape software was used to construct a drug-ingredient-target-disease network diagram. A protein-protein interaction network was constructed through String website, its key protein modules and hub genes were screened with Cytoscape software, and GO and KEGG enrichment analyses were performed in DAVID database. Fifty-nine active ingredients, 138 drug targets, and 90 targets of Salvia miltiorrhiza for the treatment of PS were screened out. Core ingredients, such as luteolin and tanshinone IIA, were obtained. The hub genes, such as VEGFA, TP53, JUN, STAT3, AKT1, MAPK1, and PTGS2, and signaling pathways, such as HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT, were screened out. Salvia miltiorrhiza might improve PS hypoxia, inflammation, and balance of proliferation and apoptosis of fibroblasts by regulating HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT signaling pathways. Moreover, it had the characteristics of multiple centers, multiple targets, and multiple pathways.

关键词： pathological scar Network pharmacology Salvia miltiorrhiza

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The Characteristics of Blood Supply and Tissue Hypoxia in pathological scars

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Chinese Medical Sciences Journal 2017年第2期32卷 113-118页

作者： ZifeiLi QingliangLiu XiaojunWang JieLuan Department of Aesthetic and Reconstructive Breast Surgery Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China Division of Plastic and Reconstructive Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking UnionMedical College Beijing 100730 China

Blood supply is believed to be an important aspect in the development of pathological scars. However, there are controversies about vascular distribution, vascular structure and blood flow in pathological scars. Additionally, hypoxic microenvironment plays an important role in the vascularization of pathological scar tissues, and hypoxic conditions can be reflected by metabolic indexes and some cytokines. Furthermore, the correlation between blood supply and tissue hypoxia is controversial. The aim of this article is to review the literature on the characteristics of blood supply and tissue hypoxia in pathological scars, from which we can see pathological scars have unique characteristics of blood supply that are closely associated with tissue hypoxia. Moreover, development in the treatment of pathological scars is herein reviewed.

关键词： pathological scar hypertrophic scar keloid blood flow hypoxia

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Macrophage Polarization in Skin Wound Healing:Progress in Biology and Therapeutics

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Journal of Shanghai Jiaotong university(Science) 2022年第2期27卷 264-280页

作者： Chen Lu Cheng Liying Chen Tian Zhang Yuguang Zhang Jianming Department of Plastic and Reconstructive Surgery the Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai200011China National Research Center for Translational Medicine Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Research and Development Center Shanghai Jahwa United Co.Ltd.Shanghai201700China

The morphological and functional barriers caused by pathological scars are extremely painful for *** to now,pathological scar poses a big unmet medical challenge for plastic surgeons and dermatologists *** polarization has shown a non-negligible effect on wound healing and scar ***,the role of macrophages in wound healing and pathological scar formation is still *** summarize the latest data on probing biological functions of macrophage polarization in wound healing and scar formation and target macrophages in wound healing,we particularly paid attention to studies on different groups of macrophages,the transition among those groups,and modulators regulating the transition process.A comprehensive understanding of macrophage polarization in wound healing is certain to facilitate the development of new and efficient therapeutic modalities for pathological scar.

关键词： macrophage polarization wound healing skin regeneration pathological scar macrophage targeted drug

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