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Recurrence in node-negative advanced gastric cancer:Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series

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World Journal of Gastroenterology 2017年第45期23卷 8000-8007页

作者： Gian Luca Baiocchi Sarah Molfino Carla Baronchelli Simone Giacopuzzi Daniele Marrelli Paolo Morgagni Maria Bencivenga Luca Saragoni Carla Vindigni Nazario Portolani Maristella Botticini Giovanni De Manzoni Department of Clinical and Experimental Sciences University of Brescia Department of Pathology Spedali Civili di Brescia 1st Department of General Surgery Borgo Trento HospitalUniversity of Verona Department of Human Pathology and Oncology Surgical OncologyUniversity of Siena Department of General Surgery Morgagni-Pierantoni Hospital Department of Pathology Morgagni-Pierantoni Hospital Department of Pathology Azienda Ospedaliera Universitaria Senese IGIER Università Bocconi

AIM To analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up. METHODS We enrolled 41 patients treated with curative gastrectomy for p T2-4 a N0 gastric carcinoma between 1992 and 2010,who developed recurrence(Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer,and compared them with 437 p T2-4 a N0 patients without recurrence(Group 2). We analyzed lymphatic embolization,microvascular infiltration,perineural infiltration,and immunohistochemical determination of p53,Ki67,and HER2 in Group 1 and in a subgroup of Group 2(Group 2 bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics. RESULTS T4 a stage and diffuse histotype were associated with recurrence in the group of p N0 patients. In-depth pathological analysis of two homogenous groups of p N0 patients,with and without recurrence during longterm follow-up(groups 1 and 2 bis),revealed two striking patterns: lymphatic embolization and perineural infiltration(two parameters that pathologists can easily report),and p53 and Ki67,represent significant factors for *** The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up.

关键词： N0 gastric cancer Recurrence Prognostic factors pathological analysis Lymphatic embolization Perineural infiltration p53 Ki67

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Auxiliary Diagnosis of Papillary Thyroid Carcinoma Based on Spectral Phenotype

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Phenomics 2023年第5期3卷 469-484页

作者： Bailiang Zhao Yan Wang Menghan Hu Yue Wu Jiannan Liu Qingli Li Min Dai Wendell QSun Guangtao Zhai Shanghai Key Laboratory of Multidimensional Information Processing East China Normal UniversityShanghai 200241China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Pathology The Second People’s Hospital of WuhuWuhu 241000AnhuiChina Ophthalmology Department Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 610101China Department of Oral Maxillofacial Head Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Image Communication and Information Processing Shanghai Jiao Tong UniversityShanghai 200240China

Thyroid cancer,a common endocrine malignancy,is one of the leading death causes among endocrine *** diagnosis of pathological section analysis suffers from diagnostic delay and cumbersome operating ***,we intend to construct the models based on spectral data that can be potentially used for rapid intraoperative papillary thyroid carcinoma(PTC)diagnosis and characterize PTC *** alleviate any concerns pathologists may have about using the model,we conducted an analysis of the used bands that can be interpreted pathologically.A spectra acquisition system was first built to acquire spectra of pathological section images from 91 *** obtained spectral dataset contains 217 spectra of normal thyroid tissue and 217 spectra of PTC *** data of the corresponding patients were collected for subsequent model interpretability *** experiment has been approved by the Ethics Review Committee of the Wuhu Hospital of East China Normal *** spectral preprocessing method was used to process the spectra,and the preprocessed signal respectively optimized by the first and secondary informative wavelengths selection was used to develop the PTC detection *** PTC detection model using mean centering(MC)and multiple scattering correction(MSC)has optimal performance,and the reasons for the good performance were analyzed in combination with the spectral acquisition process and composition of the test *** model interpretable analysis,the near-ultraviolet band selected for modeling corresponds to the location of amino acid absorption peak,and this is consistent with the clinical phenomenon of significantly lower amino acid concentrations in PTC ***,the absorption peak of hemoglobin selected for modeling is consistent with the low hemoglobin index in PTC *** addition,the correlation analysis was performed between the selected wavelengths and the clinical data,and the results show:the ref

关键词： Interpretable pathologic model pathological analysis Intraoperative detection Spectral phenotype

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Correlation between Central and Lateral Neck Dissection in Differentiated Thyroid Carcinoma

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 109-115页

作者： Olivia Mazzaschi Marine Lefevre Bruno Angelard Nathalie Chabbert-Buffet Jean Lacau St.Guily Sophie Perie Department of Otolaryngology-Head and Neck Surgery Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Pathology Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Obstetrics Gynaecology and Reproductive Medicine-Endocrinology SectionFaculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance

Objective: To determine the histopathological correlation between central and lateral neck metastasis in differentiated thyroid carcinoma, and its potential therapeutic impact. Although the central neck dissection (CND) is recommended in differentiated thyroid carcinoma, the indication for lateral neck dissection (LND) remains controversial. Design: Retrospective study. Methods and Main Outcome Measures: pathological analysis of systematic ipsilateral central neck dissection (CND) and LND performed with total thyroidectomy in differentiated thyroid carcinoma was retrospectively reviewed according to “side” and to “patient”. Results: A total of 56 sides (46 patients) were suitable for analysis. analysis by “side” revealed that CND and LND dissection samples were both negative in 15 cases, both positive in 32, CND was positive and LND was negative for 8 cases and CND was negative and LND was positive in 1 case. The combined presence of positive LND and positive CND was therefore observed in 32/40 “sides” and 26/46 “patients”. analysis by “side” of the impact of the treatment decision to perform ipsilateral LND only in patients with positive CND and vice versa demonstrated a sensitivity, specificity, and accuracy of 97%, 65%, and 84%, respectively. Conclusions: In most cases, the presence of positive LND was associated with positive ipsilateral CND. The very low prevalence of positive LND in patients with negative CND may justify LND as a second step procedure only in patients with positive CND, except in the case of documented lateral neck metastasis.

关键词： Central Neck Dissection Lateral Neck Dissection Differentiated Thyroid Carcinoma pathological analysis Thyroid Carcinoma Neck Metastasis

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