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Comparison of PAMG-1 and phIGFBP-1 Tests for the Prediction of Preterm Delivery in Patients with Preterm Labor

Open Journal of Obstetrics and Gynecology 2017年第3期7卷 358-368页

作者： Marija Hadzi-Lega Josephine Theresia Maier Hanns Helmer Lars Hellmeyer Ana Daneva Markova Anastasika Poposka Department of Obstetrics and Gynecology State University Hospital of Skopje Skopje Republic of Macedonia Department of Obstetrics and Gynecology Vivantes Klinikum im Friedrichshain Berlin Germany Division of Obstetrics and Maternal-Fetal Medicine Medical University Vienna Vienna Austria Department of Orthopedics State University Hospital of Skopje Skopje Republic of Macedonia

Objective: To compare PAMG-1 and phIGFBP-1 tests in predicting impending spontaneous preterm delivery within 7 days upon presentation in pregnant women with symptoms of preterm labor. Study Design: From September 2014 to April 2015 women with singleton gestation, symptoms of preterm labor, GA 22 - 35, participated in this prospective cohort study upon admission. Recruited patients had intact membranes and a minimal cervical dilatation of ≤3 cm. Vaginal swabs for phIGFBP-1 and PAMG-1 were taken in addition to routine treatment. Biochemical test results were blinded and had no effect on management of patients. Results: A total of 96 patients were screened for inclusion into the trial;57 met the inclusion criteria for final analysis. The PAMG-1 test was positive in 5.7% of patients, while phIGFBP-1 test was positive in 29.8% of patients. The prediction of spontaneous preterm delivery within 7 days of admission in patients with a cervical length Conclusion: Our study supports the high negative predictability of biochemical tests to rule out spontaneous preterm labor in patients with a short cervix. However, our study strongly suggests that the PAMG-1 test is more accurate for predicting imminent spontaneous preterm delivery as compared to phIGFBP-1. These findings can significantly reduce economic burden caused by unnecessary admission and treatment of patients suspected of preterm labor. Such a reduction in the use of corticosteroids and tocolytics would lead to a reduction in the short and long term health effects associated with the use of therapeutic drugs like corticosteroids, antibiotics and tocolytics.

关键词： Preterm Labour/Labor Preterm Birth phIGFBP-1 parto Sure PAMG-1

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