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Natural diatomite particles： Size-, dose- and shape- dependent cytotoxicity and reinforcing effect on injectable bone cement

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Journal of Materials Science & Technology 2018年第6期34卷 1044-1053页

作者： Xiang Zhang Huilin Yang Song Li Gaowu Qin Lei Yang College of Chemistry Chemical Engineering and Materials Science Orthopaedic Institute Soochow University Suzhou 215006 China Key LaboratoryforAnisotropy and Texture of Materials (Ministry of Education) School of Materials Science and Engineering Northeastern University Shenyang 110819 China International Research Center for Translational Orthopaedics (IRCTO) Soochow University Suzhou 215006 China

Natural diatomite （DT） is the ancient deposit of diatom skeleton with many regular pores of 50-200 nm and also an abundant source of biogenic silica. Although silica is considered biologically safe and there is an increasing interest of using natural diatomite for biomedical applications, the toxicity information about natural diatomite is still missing. Here, cytotoxicity of natural diatomite on osteoblasts and fibroblasts were compared to hydroxyapatite and the relationships between cytotoxicity and diatomite sizes, dose, geometry or impurity were systematically investigated. Cell adhesion and interaction with diatomite particles were also fluorescently observed, The results clearly suggested a size-, dose- and shape-dependent cytotoxicity of natural diatomite. Disk-shaped diatomite particles with average size of 30μm in diameter revealed the least toxicity, while the diatomite particles with irregular shapes and sizes less than 10 μm were remarkably toxic. Diatomite particles with proper sizes were then selected to investigate the reinforcing effect on injectable calcium phosphate bone cement. Results showed that diatomite significantly improved the compressive strength of bone cement but did not alter the injectability of the cement, This work provided important biocompatibility information of natural diatomite and demonstrated the feasibility of using selected diatomite as bone implant material.

关键词： Biocompatibility Size and shape effect Bone cement particle silica kyphoplasty

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