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Analysis of p53 expression in partial hydatidiform mole and hydropic abortion

Frontiers in Biology 2017年第5期12卷 357-360页

作者： Parvin Kheradmand Maede Goudarzi Mina Tavakoli Ahvaz Jundishapour University of Medical Sciences Ahvaz Iran

BACKGROUND： Gestational trophoblastic disease （GTD） is a heterogeneous group of disorders characterized by abnormal trophoblast tissue. Molar and non-molar hydropic placental changes are the most common forms of GTD. Differential diagnosis of GTD is sometimes problematic. Recently, p53 expression was identified as a good marker for distinguishing GTD types. ALMS： Comparison of p53 expression in partial hydatidiform mole （PHM） and hydropic abortion. METHODS： In this prospective cross-sectional study, molar and non-molar hydropic pregnancy specimens were collected. Immunohistochemical staining, based on the Labeled Streptavidin Biotin （LSAB） technique, was carried out on multiple 4 Ixm paraffin block sections prepared from formalin-fixed trophoblastic tissues. Polymer-based Envision was used to assess p53 tumor suppressor protein immunoreactivity, p53 expression was then compared between both groups. RESULTS： In the study, 40 patients were included： 20 with confirmed PHM and 20 with hydropic pregnancy, p53 protein was positive in 60% of patients with PHM and 25% of patients with hydropic pregnancy. The p53 positive rate was significantly higher in patients with PHM （p = 0.027）. Moreover, patients with PHM had a significantly high grade of staining （p 〈 0.001）. CONCLUSION： Our findings indicate that immunohistochemical analysis of p53 protein can be used to distinguish PHM and hydropic pregnancy.

关键词： partial hydatidiform mole hydropic abortion p53 expression

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Twin pregnancy and partial hydatidiform mole following in vitro fertilization and embryos transfer： a novel case of placental mosaicism

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Chinese Medical Journal 2012年第24期125卷 4517-4519页

作者： SUN Cheng-juan ZHAO You-ping YU Song FAN Ling, WU Qing-qing LI Guang-hui ZHANG Wei-yuan Department of Obstetrics and Gynecology Department of Ultrasonography Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Twin pregnancy with mosaic partial hydatidiform mole （PHM） and survival of two healthy fetuses following in vitro fertilization and embryos transfer （IVF-ET） is a rare situation and is considered a challenge for management. A 32-year-old Chinese woman conceived twin pregnancy following IVF-ET. At 22 weeks＇ gestation, an additional intrauterine echogenic mass with features of PHM were shown by successive ultrasound examinations. At 35 weeks＇ gestation, two live male infants and two placentas were delivered by caesarean section （CS）. Histologic examination of the abnormal placenta confirmed mosaic PHM. Genetic study showed the abnormal placental mosaicism （expressed in molar-69XXY and normal vili-46XY）, co-existing with a hypospadia new-born （46XY） in one amniotic sac. However, the other one was normal. Serial serum β-hCG levels showed a declining trend and serum β-human chorionic gonadotropin （hCG） were undetectable at 6 months after delivery. The case demonstrated that it is possible to prolonged gestation by PHM under close surveillance during the entire pregnancy.

关键词： hydatidiform mole in vitro fertilization mosaicism partial hydatidiform mole twin pregnancy

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Analysis of Clinicopathologic Classification Features of hydatidiform mole Misdiagnosed as Missed Abortion Preoperatively

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Reproductive and Developmental Medicine 2019年第2期3卷 97-101页

作者： Yun-Hui Tang Yi-Hua Sun Jin Zhu Xiao-Ying Yao Department of Family Planning Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Pathology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China

Objective:To analyze clinicopathologic classification features of the cases that were diagnosed as missed abortion preoperatively but turn out to be hydatidiform mole(HM)***:A retrospective analysis was conducted on the patients who had a missed abortion in our hospital from 2017 to *** and pathological characteristics of different types of HMs were *** value of karyotype in HM was discussed based on the karyotype analysis of villi ***:A total of 278(11.2%)HM patients were misdiagnosed as missed ***-eye detection rate of HM was 26.61%,and sensitivity of transvaginal ultrasound on HM was 7.91%.One hundred and forty-seven(52.88%)HM cases could not be genotyped via pathological hematoxylin and eosin(HE)staining.70 HM patients underwent P57 immunohistochemistry,which had guiding significance to the *** addition,the karyotype diagnosis of the tissues from 15 cases basically matched their P57 ***:P57 should be listed as a routine test in hydatidiform pathological examination at the same time of HE staining,and what’s more,P57 expression is consistent with genotyping,which should be recommended for the patients with HM if observed by naked eye.

关键词： Complete hydatidiform mole Missed Abortion P57 partial hydatidiform mole

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