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Prospective research on the efficacy and safety of oxcarbazepine as monotherapy and add-on therapy for partial epilepsy

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Frontiers of Medicine 2009年第2期3卷 181-186页

作者： Huicong KANG Xiaoyan LIU Hu QI Feng XU Xiang LI Yuan WANG Zhiguang LIU Suiqiang ZHU Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The purpose of our research was to evaluate the efﬁcacy,tolerance,and safety of oxcarbazepine(OXC)as monotherapy and add-on therapy for partial *** carried out a prospective clinical follow-up trial at the epilepsy Center of Tongji Hospital,Tongji Medical College,Huazhong University of Science and ***-seven patients with partial epilepsy received OXC *** patients were randomly divided into a monotherapy group and an add-on therapy *** observed the efﬁcacy and safety in theﬁrst three months and the following three months respectively,and compared them with each *** was a signiﬁcant difference in the decrease of seizure frequency between the two groups(P=0.002).There was a signiﬁcant difference in the percentage of seizure-free between the monotherapy and the add-on therapy groups in theﬁrst three months(P=0.02),and there were also statistical differences in the 50%response rate(P=0.017)and the percentage of seizure-free in the following three months(P=0.019).No difference was found in the 50%response rate,the 75%response rate,and the percentage of seizure-free between theﬁrst three months and the following three months in the whole group and the two subgroups(P>0.05).The incidence rate of side effects due to the therapy was 19.40%(13 of 67).The side effects were mainly found in theﬁrst three *** is concluded that OXC is theﬁrst-line anti-epileptic drug(AED)for partial seizures,and could be used as the monotherapy and add-on therapy for newly diagnosed patients and patients that failed to tolerate or beneﬁt from other AEDs.

关键词： oxcarbazepine partial epilepsy

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A follow-up study on newer anti-epileptic drugs as add-on and monotherapy for partial epilepsy in China

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Chinese Medical Journal 2012年第4期125卷 646-651页

作者： Kang Hui-cong Hu Qi Liu Xiao-yan Liu Zhi-guang Zeng Zheng Liu Jian-lin Wang Min Liang Yan-ling Zhu Sui-qiang Huazhong Univ Sci & Technol Tongji Hosp Dept Neurol Wuhan 430030 Hubei Peoples R China

Background Recently,new anti-epileptic drugs （AEDs） have been more frequently selected to treat *** the present study,we evaluated the dynamic changes of efficacy and safety of three newer AEDs for treating partial epilepsy in *** Patients were collected sequentially and were divided into three groups which accepted oxcarbazepine （OXC）,lamotrigine （LTG） or topiramate （TPM） *** group included monotherapy and add-on therapy *** followed all patients for one year and recorded the indexes of efficacy and safety in *** A total of 909 patients finished the follow-up *** significant difference was found in proportion of patients with 〉 or =50% reduction,〉 or =75% reduction and 100% seizure reduction in the LTG and OXC groups between the first and the second six *** the TPM group there was a statistical difference between the first and the second six months in proportion of patients with 〉 or =50% reduction （P=-0.002）,〉 or =75% reduction （P 〈0.0001） and 100% seizure reduction （P=0.009） in the monotherapy subgroup,and about 〉 or =75% reduction and 100% seizure reduction in the add-on therapy subgroup （P 〈0.0001）.The efficacy between the add-on and monotherapy subgroups showed a statistical *** safety of the three newer AEDs was *** The three newer AEDs all showed good efficacy and tolerability for partial *** the efficacy can be maintained for at least one year.

关键词： new anti-epileptic drug partial epilepsy efficacy safety monotherapy add-on therapy

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partial epilepsy with antecedent febrile seizures plus characterized by antiepileptic drugs-induced seizure aggravation and loss of function of Nav1.1

Partial epilepsy with antecedent febrile seizures plus chara...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wei-Ping LIAO~*,Yi-Wu SHI,Yue-Sheng LONG,Yang ZENG,Tao SU,Na HE,Bing-Mei LI,Xiao-Rong LIU, Yong-Hong YI Institute of Neuroscience and the Second Affiliated Hospital,Guangzhou Medical College,Guangzhou 510260,China

＜正＞Objective Generalized epilepsy with febrile seizures plus（GEFS+）and severe myoclonic epilepsy in infancy（SMEI）are associated with sodium channel a-subunit type-1 gene（SCNIA）mutations,although previous studies failed to correlate the functional defects（funotypes）with *** seizures and partial epilepsy are the two common features of GEFS+ and *** is thus suspected that partial epilepsy with antecedent febrile seizures（PEFS+）may also be a phenotype of SCNIA *** aggravation induced by antiepileptic drugs（AEDs）,a feature of SMEI,is considered here as a clue to find SCNIA mutations in isolated PEFS+ patients. Methods Two isolated PEFS+ patients with AEDs-induced seizure aggravation were screened for mutations in SCNIA,SCN2A,SCN1B,and GABRG2 using denaturing high-performance liquid chromatography and direct *** biophysiological features of two newly defined mutants were studied in transfected tsA201 cells using whole-cell patch-clamp *** characterize PEFS+ biologically,the genotype-funotype-phenotype relationships in all previously reported SCNIA mutations were *** One PEFS+ patient each had heterozygous de novo mutations of c.2837G＞A/p.R946H and c.5295 T＞A/p.F1765L in SCNIA,which cause the loss of function of the *** the defining of PEFS+,classifying the funotype in detail,and considering the subtle differences in the amino acid substitution,a close genotype-funotype-phenotype relationship was found in epilepsies with SCNIA mutations at a submolecular ***+ is clinically mild,with also mild channel dysfunction and mutations outside the pore ***+ is clinically similar to GEFS+,but distinct from GEFS+ in its funotype and AEDs-induced seizure ***+ is much milder than SMEI clinically,similar to SMEI biophysiologically with features of loss of function but less in degree,structurally different from SMEI by substitutions without changes in polarity. Conclusions PEFS+ may

关键词： SCN1A channelopathy partial epilepsy febrile seizures sodium channel

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Long-term Effectiveness of Antiepileptic Drug Monotherapy in partial Epileptic Patients： A 7-year Study in an epilepsy Center in China

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Chinese Medical Journal 2015年第22期128卷 3015-3022页

作者： Fei Zhu Sen-Yang Lang Xiang-Qing Wang Xiao-Bing Shi Yun-Feng Ma Xu Zhang Ya-Nan Chen Jia-Tang Zhang Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Neurology China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background： It is important to choose an appropriate antiepileptic drug （AED） to manage partial epilepsy. Traditional AEDs, such as carbamazepine （CBZ） and valproate （VPA）, have been proven to have good therapeutic effects. However, in recent years, a variety of new AEDs have increasingly been used as first-line treatments for partial epilepsy. As the studies regarding the effectiveness of new drugs and comparisons between new AEDs and traditional AEDs are few, it is determined that these are areas in need of further research. Accordingly, this study investigated the long-term effectiveness of six AEDs used as monotherapy in patients with partial epilepsy. Methods： This is a retrospective, long-term observational study. Patients with partial epilepsy who received monotherapy with one of six AEDs, namely, CBZ, VPA, topiramate （TPM）, oxcarbazepine （OXC）, lamotrigine （LTG）, or levetiracetam （LEV）, were identified and followed up from May 2007 to October 2014, and time to first seizure after treatment, 12-month remission rate, retention rate, reasons for treatment discontinuation, and adverse effects were evaluated. Results： A total of 789 patients were enrolled. The median time of follow-up was 56.95 months. CBZ exhibited the best time to first seizure, with a median time to first seizure of 36.06 months （95% confidential interval： 30.64~4.07）. CBZ exhibited the highest 12-month remission rate （85.55%）, which was significantly higher than those of TPM （69.38%, P = 0.006）, LTG （70.79%, P= 0.001）, LEV （72.54%, P = 0.005）, and VPA （73.33%, P = 0.002）. CBZ, OXC, and LEV had the best retention rate, followed by LTG, TPM, and VPA. Overall, adverse effects occurred in 45.87% of patients, and the most common adverse effects were memory problems （8.09%）, rashes （7.76%）, abnormal hepatic function （6.24%）, and drowsiness （6.24%）. Conclusion： This study demonstrated that CBZ, OXC, and LEV are relatively effective in managing tbcal epilepsy as measured by time to first seizure, 12-

关键词： 12-month Remission Rate Antiepileptic Drug partial epilepsy Retention Rate

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