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A focus on parietal cells as a renewing cell population

World Journal of Gastroenterology 2010年第5期16卷 538-546页

作者： Sherif M Karam Department of Anatomy Faculty of Medicine and Health Sciences United Arab Emirates University Al-Ain PO Box 17666 United Arab Emirates

The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthymidine radioautography in combination with electron microscopy, it was possible to demonstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem cells anchored in the isthmus region are responsible for the production of parietal cells. The stem cells give rise to three main progenitors: prepit, preneck and preparietal cells. parietal cells develop either directly from the noncycling preparietal cells or less commonly via differentiation of the cycling prepit and preneck cell progenitors. The formation of a parietal cell is a sequential process which involves diminishment of glycocalyx, production of cytoplasmic tubulovesicles, an increase in number and length of microvilli, an increase in number and size of mitochondria, and fi nally, expansion and invagination of the apical membrane with the formation of an intracellular canalicular system. Little is known about the genetic counterparts of these morphological events. However, the time dimension of parietal cell production and the consequences of its alteration on the biological features of the gastric gland are well documented. The production of a new parietal cell takes about 2 d. However, mature parietal cells have a long lifespan during which they migrate bidirectionally while their functional activity for acid secretion gradually diminishes. Following an average lifespan of about 54 d, in mice, old parietal cells undergo degeneration and elimination. Various approaches for genetic alteration of the development of parietal cells have provided evidence in support of their role as governors of the stem/progenitor cell proliferation and differentiation programs. Revealing the dynamic features and the various roles of parietal cells would help

关键词： cell differentiation cell dynamics cell renewal Oxyntic gland Oxyntic mucosa parietal cell Preparietal cell

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Effect of Mica Monomer Powder on Chief and parietal cells as well as G and D cells in Gastric Mucosa of Chronic Atrophic Gastritis in Rats

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Chinese Journal of Integrative Medicine 2008年第2期14卷 111-116页

作者：朱方石姒健敏王良静王冬飞陈萍 Academy of Traditional Chinese Medicine of Jiangsu Province Sir Run Run Shaw Clinical Medical Institute Zhejiang University

Objective： To study the regulative action of mica monomer powder preparation on the chief and parietal cells as well as G and D cells in the gastric mucosa of the experimental atrophic gastritis （CAG） rats. Methods： Intervention therapy was given to the experimental CAG rats at three different doses of mica monomer powder preparation to evaluate the changes of chief and parietal cells as well as G and D cells in the gastric mucosa and the histopathological changes of gastric mucosa. Results： Mica monomer powder preparation at three different doses could increase the amount of chief and parietal cells as well as G and D cells in gastric mucosa of the experimental CAG rats and alleviate and control the inflammation of gastric mucosa and the atrophy of gastric mucosa glands. Especially, better effects were shown in the mid and high dose groups. Conclusion： Mica has the pharmacological action of protecting the gastric mucosa, promoting the regeneration of gastric glands, enhancing blood flow of the gastric mucosa, and consequently improving the inflammatory responses of the gastric mucosa. One of the mechanisms is associated with promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism including gut hormone secretion （gastrin and somatostatin） by increasing the number of chief and parietal cells as well as G and D cells.

关键词： mica chronic atrophic gastritis chief cell parietal cell G cell D cell

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Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1031-1041页

作者： P.Trevisi D.Luise F.Correa S.Messori M.Mazzoni J.P.Lallès P.Bosi Department of Agricultural and Food Sciences University of BolognaViale G.Fanin 4640127 BolognaItaly Present Address:World Organisation for Animal Health(OIE) Scientific Secretariat for the STAR-IDAZ International Research Consortium on animal health12 rue de Prony75017 ParisFrance Department of Veterinary Sciences University of BolognaVia Tolara di SopraOzzano nell’Emilia(BO)BolognaItaly INRAE Human Nutrition DivisionSite of Theix63122 Saint-Genès-ChampanelleFrance

Background:Scarce is knowledge on the process regulating the development of acid secretion,orexigenic signaling,and chemosensing in the stomach of young *** of early microbial encounters by suckling pigs can interact with the gut maturation,by the induction of different molecular *** goal was to assess if the age of offspring and the maternal environment,influenced by sow antibiotic treatment peripartum,could affect gastric morphology and the expression of genes involved in the control of hydrochloric secretion,feed intake,taste,and inflammation in offspring ***:84 pigs from sows fed a diet with amoxicillin(on-d10 to+d21 from farrowing,ANT)or without(CON)were sacrificed at d14,d21,d28(weaning)or *** of oxyntic(OXY),pyloric(PY)and cardiac mucosae close to OXY were collected and parietal and enteroendocrine cells(EECs)were *** gene expression of a set of 11 key genes(ATP4A,SSTR2,GAST,GHRL,MBOAT4,PCSK1,GNAT1,TAS1R1,TAS1R3,IL8 and TNF)was assessed by *** addition,40 offspring obtained from the same ANT and CON sows were offered a normal or a fatenriched diet for 4 weeks between 140 and 169 d of age,and then OXY and PY were ***:The number of parietal and EECs increased with age(P<0.001).ATP4A increased with age(within suckling,P=0.043,post-weaning ***,P<0.001),SSTR2 increased only after weaning(P<0.001).In OXY,GHRL increased during suckling(P=0.012),and post-weaning as a trend(P=0.088).MBOAT4 tended to increase during suckling(P=0.062).TAS1R1 increased from suckling to post-weaning period(P=0.001)and was lower in ANT offspring(P=0.013).GNAT1 in PY was higher in ANT offspring(P=0.041).Antibiotic treatment of sows peripartum increased expression of GHRL and MBOAT4 in OXY of growing-finishing offspring aged 5 ***:Data show that sensing for umami taste and ghrelin regulation can be affected by maternal environment,but the development of acid secretion,orexigenic signaling and taste

关键词： Enteroendocrine cell Gastrin Ghrelin parietal cell Stomach Taste receptor

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