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Natural Products and Bioprospecting 2018年第3期8卷 151-169页

作者： Conrad V.Simoben Fidele Ntie-Kang Sergi H.Akone Wolfgang Sippl Institute of Pharmacy Martin-Luther University of Halle-WittenbergWolfgang-Langenbeck-Str.406120 Halle(Saale)Germany Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63Buea 00237Cameroon Institute of Pharmaceutical Biology and Biotechnology Heinrich-Heine-UniversityUniversitaetsstrasse1Geb.26.23Duesseldorf 40225Germany Department of Chemistry Faculty of ScienceUniversity of DoualaPO Box 24157Douala 00237Cameroon

parasitic diseases continue to represent a threat on a global scale,particularly among the poorest countries in the world.This is particularly because of the absence of vaccines,and in some cases,resistance against available drugs,currently being used for their treatment.In this review emphasis is laid on natural products and scaffolds from African medicinal plants(AMPs)for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases.In the discussion,emphasis has been laid on alkaloids,terpenoids,quinones,flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma,Trypanosoma and Leishmania species.In each subparagraph,emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds.Suggestions for future drug development from African medicinal plants have also been provided.This review covering 167 references,including 82 compounds,provides information published within two decades(1997-2017).

关键词： African medicinal plants Leishmaniasis Natural products parasitic diseases Schistosomiasis Trypanosomiasis

Effects of parasitic diseases on the Cardiovascular System

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Journal of Biosciences and Medicines 2022年第6期10卷 90-102页

作者： Tao Zhang Jun Jiang Jianfa Liu Department of Parasitology Ningbo University School of Medicine Ningbo China Department of Cardiology Fenghua People’s Hospital Ningbo China Department of Infectious Disease School of Medicine The Affiliated Hospital of Ningbo University Ningbo China

The parasitic disease can significantly affect the cardiovascular system through various mechanisms;even though it is traditionally regarded as a disease characterized by parasitic sites’ mechanical damage and some immune responses. Recent studies have shown that the role of parasitic factors in the cause of death due to cardiovascular events cannot be ignored. Considering the worldwide prevalence of parasitic diseases, exploring the effects of parasitic diseases on the cardiovascular system becomes increasingly essential. Here we summarize the latest understanding of common parasitic infections, explore the possible mechanisms of cardiovascular responses to parasitic infections, and propose feasible strategies for preventing and treating parasite-induced cardiac reactions.

关键词： Parasite parasitic diseases Chagas Cardiomyopathy Cardiovascular System

Foodborne parasitic diseases in China:A scoping review on current situation,epidemiological trends,prevention and control

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Asian Pacific Journal of Tropical Medicine 2021年第9期14卷 385-400页

作者： Langui Song Qingxing Xie Zhiyue Lv The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhenGuangdongChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikouChina NHC Key Laboratory of Control of Tropical diseases the First Affiliated HospitalHainan Medical UniversityHaikouChina Key Laboratory of Tropical Disease Control Sun Yat-sen UniversityMinistry of EducationGuangzhouChina

Objective:Foodborne parasitic diseases,although with a declining overall incidence rate,are still endangering local public safety.This review aims to describe the current situation and epidemiological trends of foodborne parasitic diseases in China in order to explore possible reasons contributors to its high prevalence in some areas,and propose strategies for prevention and control accordingly.Methods:A scoping review was conducted by searching Pub Med,CNKI,Wanfang,CQVIP,Embase,and the Cochrane Library using search formula"foodborne parasitic diseases(or foodborne parasites)"AND"China".Studies on foodborne parasitic diseases in China were considered,but only articles in English or Chinese published between January 1980 and June 2020 were retrieved.Included studies were screened according to the eligibility criteria:1)diseases consistent with the WHO definition of foodborne parasitic diseases;2)the food carriers were included in the WHO food classification;3)data related to epidemiology,pathogenicity,and prevention and control;4)Foodborne parasitic diseases cases or outbreaks in China.Results:A total of 111 out of 665 records were included and summarized.The prevalence of clonorchiasis,angiostrongyliasis,echinococcosis,trichinellosis and cysticercosis was still increasing although the infection rate of soil-transmitted nematodes has substantially decreased in recent years.Diverse eating habits,close contact with animals,and urbanization were contributing factors to the increase.Conclusions:Foodborne parasitic diseases remain an important public health issue in China with the progress of economic globalization and food diversification.We should manage to raise public awareness about the prevention and control of foodborne parasitic diseases,improve health and safety inspections,as well as public health practice.

关键词： Foodborne diseases parasitic diseases China Preventive medicine

Imported parasitic diseases in China's Mainland:current status and perspectives for better control and prevention

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Infectious diseases of Poverty 2018年第1期7卷 770-780页

作者： Lan-Gui Song Xing-Da Zeng Yan-Xia Li Bei-Bei Zhang Xiao-Ying Wu Dong-Juan Yuan Ai He Zhong-Dao Wu Department of Parasitology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080GuangdongChina Key Laboratory of Tropical diseases Control(SYSU) Ministry of EducationGuangzhou 510080GuangdongChina Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou 510080GuangdongChina Jiangxi Provincial Testing Center of Medical Apparatus and Instruments Nanchang 330029JiangxiChina School of Public Health Fudan UniversityShanghai 200433China

Background:The high prevalence of parasitic diseases leads to millions of deaths and disabilities each year in developing countries.China has also been greatly affected by parasitic infections,including filariasis,leishmaniasis,malaria,schistosomiasis,and soil-transmitted nematodosis.However,the situation in China improved dramatically after comprehensive parasitic disease control efforts were strengthened,leading to the elimination of filariasis in 2006 and to significant control over other diseases.However,imported parasitic disease cases are inevitable,and such cases have increasingly been reported as a result of enhanced globalization and international or regional cooperation.These imported diseases represent a major obstacle to the elimination of several parasitoses,such as malaria.Main text:This paper reviews imported cases of parasitic diseases in China's Mainland,particularly malaria and schistosomiasis,based on data reported separately by the Chinese annual reports and from other published papers.We summarize the new challenges that face parasitic disease control efforts in China's Mainland and perspectives regarding better control.We argue that both the provision of professional education and updated training for medical care personnel and the management and surveillance of people entering China are essential.We recommend that Chinese migrant workers should be considered a priority group for health education and that public awareness of imported diseases should be emphasized.Furthermore,we underscore the importance of investigating the distribution of introduced/potential vectors,parasite susceptibility,and improvements in diagnostic techniques and drug stocks.Conclusions:Imported cases have become the main challenge to the elimination of several parasitoses,such as malaria and schistosomiasis,in China's Mainland.China should act to meet these challenges,which are closely associated with national biological safety.

关键词： parasitic diseases Imported disease China

Parasitology should not be abandoned:data from outpatient parasitological testing in Guangdong,China

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Infectious diseases of Poverty 2017年第1期6卷 1061-1066页

作者： Lan-Gui Song Xiao-Ying Zheng Da-Tao Lin Guang-Xi Wang Zhong-Dao Wu Department of Parasitology of Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control(SYSU) Ministry of EducationGuangzhou 510080China Provincial Engineering Technology Research Center for Biological Vector Control GuangzhouGuangdong 510080China Southwest Medical University LuzhouSichuan 646000China

Over the past six decades,the Chinese government made parasitoses with a high disease burden,including soiltransmitted nematode infections,malaria,leishmaniasis,filariasis,and schistosomiasis,a public health priority because they were seen to be crucial impediments to the development of rural areas.As a result,these debilitating parasitic diseases that used to be widely prevalent have been well controlled or eliminated.Consequently,less attention has been paid to parasitic infection during the rapid development of the economy,especially in developed areas.However,our investigations conducted in the parasitological laboratory of Sun Yat-sen University(Guangzhou,Guangdong,China)show that emerging parasitic diseases still threaten many people’s health,with 340 of 880 outpatients(38.6%)receiving a diagnosis of parasitic disease,among whom 201(59.1%)had clonorchiasis and 120(35.3%)had taeniasis/cysticercosis.Furthermore,our doctors are not equipped with sufficient parasitology knowledge because this discipline is not able to maintain attraction.Many parasitic infections that result in severe consequences are treatable and preventable,but the phenomena of misdiagnosis and missed diagnosis are common and merit attention.

关键词： parasitic diseases Parasitology Guangdong Province P.R.China

The epidemiological models of Karl-Peter Hadeler

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Infectious Disease Modelling 2018年第1期3卷 171-175页

作者： Klaus Dietz Department of Medical Biometry(Emeritus) University of Tübingen72076TübingenGermany

The most frequently cited articles out of KP Hadeler's 45 papers with epidemiological applications are summarized.parasitic diseases which increase the death rate of the hosts proportional to the integer number of parasites present were described by integral equations for the generating function of the age-and time-dependent number of parasites.A model was derived for a population structured by the continuous level of parasitic infection.Stimulated by the spread of AIDS a new class of epidemic models was developed which take into account explicitly the formation and separation of pairs.For predator-prey populations with parasitic infections threshold conditions for the persistence of the predator were derived.The interaction of epidemics and demography was analysed.Several epidemiological conditions led to backward bifurcations associated with multiple infective stationary states.

关键词： Epidemic models parasitic diseases Pair formation Predator-prey populations Epidemics and demography Backward bifurcation

Microbe/Bug-Busters Visit the Interactive House: An Itinerant Scenographic Device for Health Education

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Open Journal of Animal Sciences 2021年第2期11卷 333-353页

作者： Ana Márcia Suarez-Fontes Juliana Almeida-Silva Sarah Cristina dos Santos Silva Letícia Sant’Anna de Souza Daniele Brum de Souza Conceição Suarez Fontes de Araújo Lima Marcos André Vannier-Santos Laboratório de Inovações em Terapia Ensino e Bioprodutos (LITEB) Instituto Oswaldo Cruz (IOC)—Funda&#231&#227o Oswaldo Cruz (Fiocruz) Rio de Janeiro Brazil

The term Ecology is derived from οἶκος (Greek “house” or environment), but our habitations usually overlooked in ecology or environmental studies. The expression “at home” usually means safety and comfort, but at home we are under risk of innumerous parasitic/microbial infections and contaminations/ envenomation. During the COVID-19 pandemic we were forced to stay at home, but the virus and other pathogens were also home-delivered. Education for health is highly effective in health promotion, particularly in poor areas. Thus, prophylactic interventions approaching household environment are required. The present activity aims community empowerment and engagement in controlling parasitic diseases and other infections such as Chagas disease, leishmaniasis, malaria, arboviruses etc. Inspired on the use of a house maket by Dr. Virgínia Schall to demonstrate Aedes mosquitoes breeding sites. We also employ house makets displaying pathogen vectors breeding/hiding sites. Although some makets can be opened, revealing intradomiciliary milieu, we intended to offer the public a literally “insider” view of this largely overlooked scenery. The “Interactive House”, also known as “House with no viruses and other bugs” is an educative, interactive, ludic device elaborated on an inflatable igloo, with furniture and utensils crafted using reused/recycled or low-cost materials. Live mosquito larvae were placed at peridomicile in water-accumulating plant pot saucer, leaves-clogged gutter, used tire, dog water bowl as well as within the domicile, in the shower drain trap. Evidengue®, crafted in cloth to bloc

关键词： Science Communication Health Education One Health Environmental Health parasitic diseases