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paraparesis caused by transarterial chemoembolization:A case report

World Journal of Hepatology 2010年第7期2卷 289-291页

作者： Kashif Tufail Victor Araya Ashaur Azhar David Hertzog Kamran Khanmoradi Jorge Ortiz Department of Hepatology Albert Einstein Medical Center Department of Radiology Albert Einstein Medical Center Department of Transplant Surgery Albert EinsteinMedical Center

Transarterial chemoembolization (TACE) is an effective modality for the treatment of Hepatocellular Carcinoma. It is used to treat small tumors and to downstage large tumors to meet liver transplant criteria. TACE can be associated with multiple side effects, including fever, right upper quadrant pain, nausea, vomiting, hepatic failure, hepatic encephalopathy, cholecystitis and pancreatitis. Neurological complications after TACE are rare, usually caused by cerebral embolism, and confirmed by means of imaging studies. Spinal cord ischemia secondary to TACE is extremely rare and can lead to significant morbidity. We report a case of paraparesis caused by TACE with normal imaging and nerve conduction studies, suggestive of localized vasculitis.

关键词： Transarterial chemoembolization paraparesis Spinal cord ischemia Hepatocellular carcinoma

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Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Clinical presentation and pathophysiology

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World Journal of Neurology 2015年第3期5卷 68-73页

作者： Jean-Pierre Louboutin Department of Basic Medical Sciences University of the West Indies Mona Campus

Human T-cell lymphotropic virus type 1(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP) is a slowly progressive neurodegenerative disorder in which lesions of the central nervous system cause progressive weakness, stiffness, and a lower limb spastic paraparesis. In some cases, polymyositis, inclusion bodymyositis, or amyotrophic lateral sclerosis-like syndromes are associated with HTLV-1. TSP was first described in Jamaica in 1888 and known as Jamaican peripheral neuritis before TSP was related to HTLV-1 virus, the first retrovirus being identified, and the disease is since named HAM/TSP. There is no established treatment program for HAM/TSP. Prevention is difficult in lowincome patients(i.e., HTLV-1 infected breast feeding mothers in rural areas, sex workers). Thus, there is a need for new therapeutic avenues. Therapeutic approaches must be based on a better understanding, not only of clinical and clinicopathological data, but also of the pathophysiology of the affection. Consequently, a better understanding of existing or newly developed animal models of HAM/TSP is a prerequisite step in the development of new treatments.

关键词： Tropical spastic paraparesis Human T-cell lymphotropic virus type-1 Polymyositis Animal models Retroviruses Myelopathy Human T-cell lymphotropic virus type 1-associated myelopathy Pathogenesis

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Role of post-translational modifications of HTLV-1 Tax in NF-κB activation

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World Journal of Biological Chemistry 2010年第1期1卷 13-20页

作者： Noula Shembade Edward W Harhaj Department of Micro-biology and Immunology Sylvester Comprehensive Cancer CenterUniversity of MiamiMiller School of MedicineMiamiFL 33136United States

Human T-cell leukemia virus type 1(HTLV-1),the first human retrovirus discovered,is the etiological agent of adult-T-cell leukemia/*** HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene expression by constitutively activating nuclear factor-κB(NF-κB).Tax activation of NF-κB is critical for the immortalization and survival of HTLV-1-infected T *** this review,we summarize the present knowledge on mechanisms underlying Tax-mediated NF-κB activation,with an emphasis on post-translational modifications of Tax.

关键词： Adult-T-cell leukemia/lymphoma Human T-cell leukemia virus type 1 Nuclear factor-κB Human T-cell leukemia virus type 1-associated myelopathy/ tropical spastic paraparesis IKK

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