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Integrated liver proteomics and metabolomics identify metabolic pathways affected by pantothenic acid deficiency in Pekin ducks

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Animal Nutrition 2022年第4期11卷 1-14页

作者： Jing Tang Yongbao Wu Bo Zhang Suyun Liang Zhanbao Guo Jian Hu Zhengkui Zhou Ming Xie Shuisheng Hou State Key Laboratory of Animal Nutrition Key Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsInstitute of Animal SciencesChinese Academy of Agricultural Sciences100193BeijingChina

pantothenic acid deficiency(PAD)in animals causes growth depression,fasting hypoglycemia and impaired lipid and glucose ***,a systematic multi-omics analysis of effects of PAD on hepatic function has apparently not been *** investigated liver proteome and metabolome changes induced by PAD to explain its effects on growth and liver metabolic *** ducks(1-dold,n=128)were allocated into 2 groups,with 8 replicates and 8 birds per *** 16 d,all ducks had ad libitum access to either a PAD or a pantothenic acid adequate(control,CON)diet,formulated by supplementing a basal diet with 0 or 8 mg pantothenic acid/kg of diet,*** enlargement,elevated liver glycogen concentrations and decreased liver concentrations of triglyceride and unsaturated fatty acids were present in the PAD group compared to the CON *** on integrated liver proteomics and metabolomics,PAD mainly affected glycogen synthesis and degradation,glycolysis and gluconeogenesis,tricarboxylic acid(TCA)cycle,peroxisome proliferator-activated receptor(PPAR)signaling pathway,fatty acid beta oxidation,and oxidative *** proteins were confirmed by Western *** of proteins and metabolites involved in glycogen synthesis and degradation,glycolysis and gluconeogenesis implied that these processes were impaired in PAD ducks,which could have contributed to fasting hypoglycemia,liver glycogen storage,insufficient ATP production,and growth *** contrast,PAD also upregulated proteins and metabolites involved in fatty acid beta oxidation,the TCA cycle,and oxidative phosphorylation processes in the liver;presumably compensatory responses to produce *** inferred that PAD decreased liver triglyceride and unsaturated fatty acids by activating fatty acid beta oxidation and impairing unsaturated fatty acid *** findings contributed to our understanding of the mechanisms of PAD-induced changes in hepatic metabol

关键词： pantothenic acid Hepatic metabolism Proteomics Metabolomics Hypoglycemia

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Effects of pantothenic acid on growth performance,slaughter performance, lipid metabolism, and antioxidant function of Wulong geese aged one to four weeks

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Animal Nutrition 2016年第4期2卷 312-317页

作者： Baowei Wang Xiao Zhang Bin Yue Wenhua Ge Mingai Zhang Chuanxing Ma Min Kong Institute of High Quality Waterfowl Qingdao Agricultural University Nutrition and Feed Laboratory of China Agriculture Research System

This experiment was conducted to study the effects of pantothenic acid on the growth performance,slaughter performance, lipid metabolism, and antioxidant function of one-to four-week-old Wulong geese and determine the appropriate supplemental level of pantothenic acid. A total of 360 one-day-old Wulong geese were randomly divided into 6 groups with 6 replicates per group and 10 geese(5 males and 5 females) per replicate. The geese in group Ⅰ(control group) were fed a basal diet, and the geese in groups Ⅱ to Ⅵ(experimental groups) were given the basal diet supplemented with 8, 15, 30, 60, and120 mg/kg pantothenic acid, respectively. The experiment lasted for 4 weeks. Based on the results of unrelated comparative analysis, the body weight was the highest when the dietary pantothenic acid level was 27.57 mg/kg. When the dietary pantothenic acid level was 26.17 mg/kg, the average daily gain peaked. When the dietary pantothenic acid level was 15.50 mg/kg, the feed:gain ratio was the *** percentage of abdominal fat in groups Ⅲ and Ⅳ was significantly lower than that in group Ⅰ(P pantothenic acid in the diet of one-to four-week-old Wulong geese significantly

关键词： Production performance Lipid metabolism Antioxidant function pantothenic acid Wulong geese

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***＿（12）INTHESHRIMPPENAEUSCHINENSI

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中国水产科学 1995年第4期 48-55页

作者： Liu Tiebin, Zhang Jiameng , Li Aijie(Ocean University of Qingdao 266003)

ＳＴＵＤＩＥＳＯＮＴＨＥＯＰＴＩＭＡＬＲＥＱＵＩＲＥＭＥＮＴＳＯＦＰＡＮＴＯＴＨＥＮＩＣＡＣＩＤ．ＢＩＯＴＩＮ．ＦＯＬＩＣＡＣＩＤＡＮＤＢ＿（１２）ＩＮＴＨＥＳＨＲＩＭＰＰＥＮＡＥＵＳＣＨＩＮＥＮＳＩＳＬｉｕＴｉｅｂ... 详细信息

ＳＴＵＤＩＥＳＯＮＴＨＥＯＰＴＩＭＡＬＲＥＱＵＩＲＥＭＥＮＴＳＯＦＰＡＮＴＯＴＨＥＮＩＣＡＣＩＤ．ＢＩＯＴＩＮ．ＦＯＬＩＣＡＣＩＤＡＮＤＢ＿（１２）ＩＮＴＨＥＳＨＲＩＭＰＰＥＮＡＥＵＳＣＨＩＮＥＮＳＩＳＬｉｕＴｉｅｂｉｎ，ＺｈａｎｇＪｉａｍｅｎｇ，Ｌ...

关键词： Penaeus chinensis Vitamin pantothenic acid Biotin Folic acid Vitamin B12.

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