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paget’s disease of bone: Report of 11 cases

World Journal of Clinical Cases 2021年第14期9卷 3478-3486页

作者： Xin-Yu Miao Xian-Ling Wang Zhao-Hui Lyu Jian-Ming Ba Yu Pei Jing-Tao Dou Wei-Jun Gu Jin Du Qing-Hua Guo Kang Chen Yi-Ming Mu Department of Endocrinology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Endocrinology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China

BACKGROUND paget’s disease of bone(PDB)is a rare metabolic bone disease in China and is characterized by increased bone resorption and disorganized bone *** main clinical symptoms of PDB are focal or multiple bone pain and deformity with high *** disease has high missed diagnosis and misdiagnosis *** report summarizes the clinical manifestations,imaging and pathological features,and treatments of 11 patients with PDB at our hospital from 1993 to 2020 in order to improve the recognition and prognosis of *** sUMMARY There were eight male and three female patients whose average age was 48.7±11.0 years with a PDB course of 1-16 *** patients had bone pain and bone deformities in different parts of the body,the majority of which involved the long *** examinations revealed elevated serum alkaline phosphatase(ALP)in all patients with an average of 618±460 IU/L(normal range 0-130 IU/L),and serum calcium and phosphorus levels were in the normal *** showed that osteolysis was usually combined with osteosclerosis and/or bone deformities in single or multiple bones.^(99m)Tc-methylene diphosphonate bone scintigraphy revealed increased radionuclide uptake in the bone *** patients underwent bone tissue biopsy,and the typical pathological changes were a mosaic structure of the bone trabeculae with irregularly arranged cement lines and multinuclear *** of the 11 patients were effectively treated with *** Early diagnosis of the rare disease PDB can be made through elevated ALP levels and typical presentations on bone X-ray and from bone tissue biopsy.

关键词： paget’s disease of bone Metabolic bone diseases Chinese Case report

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