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In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from paecilomyces hepiali

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Food Science and Human Wellness 2023年第4期12卷 1204-1211页

作者： Akang Dan Yushi Chen Yongqi Tian Shaoyun Wang College of Biological Science and Technology Fuzhou UniversityFuzhou 350108China College of Chemical Fuzhou UniversityFuzhou 350108China

The purpose of this study was to explore the potential of the development and application of paecilomyces hepiali,a fungus with edible and medicinal value,as a foodborne antioxidant and anti-aging *** n-butanol extract(PHE)from rice cultures was selected for anti-aging experiment because of significant free radical scavenging activity in *** vivo,PHE could significantly prolong the mean lifespan,50%survival days,and the maximum lifespan of Drosophila on a high-fat *** is amazing that the mean lifespan increased from 19.1 days to 32.9 days,50%survival days increased from 15.7 days to 34.3 days,and the maximum lifespan extended from 44.7 days to 52.7 days,when the high-fat female Drosophila model was fed with 10μg/mL *** research showed that PHE reduced the accumulation of peroxide products and increased the activity of antioxidant ***,through antioxidant activity tracking,dimerumic acid(compound 1,the IC_(50) value of 3.4μg/mL on DPPH free radicals scavenging activity),4,5-dihydroxy-3-methoxypentanoic acid(compound 2,new compound),and thymidine(compound 3)were isolated from *** is worth mentioning that dimerumic acid,the major antioxidant compound of PHE(content up to 3%),was discovered in *** for the first *** was concluded that PHE showed excellent anti-aging activity at a very low concentration on fat diet-induced high fat Drosophila melanogaster,and dimerumic acid may be its main material *** results indicated that PHE had the potential to be developed as antioxidant and anti-aging agent in the healthcare industry.

关键词： paecilomyces hepiali Anti-aging Drosophila Dimerumic acid

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Multigene phylogeny of the family Cordycipitaceae (Hypocreales): new taxa and the new systematic position of the Chinese cordycipitoid fungus paecilomyces hepiali

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Fungal Diversity 2020年第4期103卷 1-46页

作者： Yuan-Bing Wang Yao Wang Qi Fan Dong-E Duan Guo-Dong Zhang Ru-Qin Dai Yong-Dong Dai Wen-Bo Zeng Zi-Hong Chen Dan-Dan Li De-Xiang Tang Zhi-Hong Xu Tao Sun Thi-Tra Nguyen Ngoc-Lan Tran Van-Minh Dao Can-Ming Zhang Luo-Dong Huang Yong-Jun Liu Xiao-Mei Zhang Da-Rong Yang Tatiana Sanjuan Xing-Zhong Liu Zhu L.Yang Hong Yu Yunnan Herbal Laboratory School of Ecology and Environmental ScienceYunnan UniversityKunming 650091China The International Joint Research Center for Sustainable Utilization of Cordyceps Bioresources in China and Southeast Asia Yunnan UniversityKunming 650091China The Research Center of Cordyceps Development and Utilization of Kunming Yunnan Herbal Biotech Co.Ltd.Kunming 650106China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Fungal Diversity and Green Development Kunming 650201China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China College of Evironment and Resources Wenshan UniversityWenshan 663099China Institute of Biological Resources of Gaoligong Mountains Baoshan UniversityBaoshan 678000China Institute of Regional Research and Development Ministry of Science and TechnologyHanoiVietnam YiKangBao Biotech Co. LtdShangri-La 674400China School of Chemical Science and Engineering Yunnan UniversityKunming 650091China College of Basic Medicine Yunnan University of Chinese MedicineKunming 650500China Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming 650223China Laboratorio de Taxonomíay Ecología de Hongos Universidad de Antioquiacalle 67 No.53-12108A.A.1226MedellinColombia State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

The phylogeny and systematics of cordycipitoid fungi have been extensively studied in the last two ***,systematic positions of some taxa in the family Cordycipitaceae have not yet been thoroughly *** this study,a new phylogenetic framework of Cordycipitaceae is reconstructed using multigene(nrSSU,nrLSU,tef-1α,rpb1 and rpb2)sequence data with large-scale taxon *** addition,ITS sequence data of species belonging to the Lecanicillium lineage in the family Cordycipitaceae are used to further determine their phylogenetic *** on molecular phylogenetic data together with morphological evidence,two new genera(Flavocillium and Liangia),16 new species and four new combina-tions are *** the new genus Flavocillium,one new species *** and three new combinations previously described as Lecanicillium,namely ***,*** and ***,are *** genus Liangia is built by the new species *** with Lecanicillium-like asexual morph,isolated from an entomopathogenic fungus Beauveria *** to the absence of paecilomyces hepiali,an economically and medically significant fungus,in the earlier phylogenetic analyses,its systematic position has been puzzling in both business and academic communities for a long ***,*** is recharacterized using the holotype material along with seven additional *** is assigned to the genus Samsoniella(Cordycipitaceae,Hypocreales)possessing Cordyceps-like sexual morph and Isaria-like asexual morph,and thus a new combination,namely *** is *** additional nine new species in Samsoniella are described:***,***,***,***,***,***,***,*** and *** new species in Cordyceps are described:***,***,*** and *** yunnanense,isolated from synnemata of Akanthomyces waltergamsii,is described as a new species.

关键词： Cordycipitaceae Cordyceps Flavocillium Liangia paecilomyces hepiali Phylogeny Samsoniella

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Advances in research on chemical constituents and pharmacological effects of paecilomyces hepiali

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Food Science and Human Wellness 2021年第4期10卷 401-407页

作者： Akang Dan Yujia Hu Ruyan Chen Xiangyang Lin Yongqi Tian Shaoyun Wang School of Biological Science and Technology Fuzhou UniversityFuzhou 350108China

paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps *** main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and *** to the huge development potential of *** in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the *** this paper,the chemical constituents and their pharmacological effects of *** are reviewed,which can provide reference for the development and application of ***.

关键词： paecilomyces hepiali Chemical constituents Pharmacological effects

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Maturational alterations of the differential fungal expressions of at least six mutant genotypes of Ophiocordyceps sinensis in natural Cordyceps sinensis

Maturational alterations of the differential fungal expressi...

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海峡两岸第十届菌物学暨第三届食药用菌学术研讨会

作者： ZHU Jia-Shi~(1,2,3*) YAO Yi-Sang~3 GAO Ling~3 LI Xiao-Hong~4 ZHAO Jian-Qing~4 1 Nuskin Center for Anti-Aging research,Provo,UT 84601,USA 2 School of Pharmacy,Shihezi University,Shihezi,Xinjiang 832000,China 3 Pharmanex Beijing Clinical Pharmacology Center,Beijing 100088,China 4 CapitalBio Co.,Changping,Beijing 102206,China

＜正＞冬虫夏草（Cordyceps sinensis）因其生长成熟过程中的形态变化而得名,又因其阴阳双补的临床功效而名扬天下。数百年来这味名贵中药用于医疗保健、疾病治疗和病后康复。现代科学研究验证了冬虫夏草

关键词： Cordyceps sinensis GC- and AT-biased genotypes of Ophiocordyceps sinensis transition mutation transversion mutation differential fungal expression of mutant genotypes paecilomyces hepiali Hirsutella sinensis

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