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Innate recognition of microbial-derived signals in immunity and inflammation

Science China(Life Sciences) 2016年第12期59卷 1210-1217页

作者： Yue Zhang Chunli Liang Department of General Surgery East HospitalTongji University School of Medicine

Microbes generate a vast array of different types of conserved structural components called pathogen-associated molecular patterns(PAMPs),which canbe recognized by cells of the innate immune *** recognition of "nonself" signatures occurs through host pattern recognition receptors(prrs),suggesting that microbial-derived signals are good targets for innate immunity to discriminate between self- and *** PAMP-prr interactions trigger multiple but distinct downstream signaling cascades,subsequently leading to production of proinflammatory cytokines and interferons that tailor immune responses to particular *** prr signals have been associated with various inflammatory diseases and fine regulation of prr signaling is essential for avoiding excessive inflammatory immune responses and maintaining immune *** this review we summarize the ligands and signal transduction pathways of prrs and highlight recent progress of the mechanisms involved in microbe-specific innate immune recognition during immune responses and inflammation,which may provide new targets for therapeutic intervention to the inflammatory disorders.

关键词： microbial-derived components prr signaling immune regulation innate immunity inflammation

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The roles of microglia in viral encephalitis:from sensome to therapeutic targeting

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Cellular & Molecular Immunology 2021年第2期18卷 250-258页

作者： Chintan Chhatbar Marco Prinz Institute of Neuropathology Medical FacultyUniversity of FreiburgFreiburgGermany Center for Basics in NeuroModulation(NeuroModulBasics) Faculty of MedicineUniversity of FreiburgFreiburgGermany Signalling Research Centres BIOSS and CIBSS University of FreiburgFreiburgGermany

Viral encephalitis is a devastating disease with high mortality,and survivors often suffer from severe neurological *** are innate immune cells of the central nervous system(CNS)parenchyma whose turnover is reliant on local *** express a diverse range of proteins,which allows them to continuously sense the environment and quickly react to *** inflammatory conditions such as CNS viral infection,microglia promote innate and adaptive immune responses to protect the ***,during viral infection,a dysregulated microglia-T-cell interplay may result in altered phagocytosis of neuronal synapses by microglia that causes neurocognitive *** this review,we summarize the current knowledge on the role of microglia in viral encephalitis,propose questions to be answered in the future and suggest possible therapeutic targets.

关键词： microglial activation viral encephalitis neurocognitive issues purinergic signaling prr signaling

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