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ppargc1a rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2021年第25期27卷 3863-3876页

作者： Rui-Nan Zhang Feng Shen Qin Pan Hai-Xia Cao Guang-Yu Chen Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Clinical Epidemiology Research Center Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China

BACKGROUND The association between ppargc1a rs8192678 and nonalcoholic fatty liver disease(NAFLD)requires further *** addition,it is still unknown whether ppargc1a rs8192678 is associated with hepatic histological features in NAFLD in the Chinese *** To investigate the interaction between ppargc1a rs8192678 and nonalcoholic steatohepatitis(NASH),and whether this polymorphism is associated with hepatic histological *** Fifty-nine patients with liver biopsy-proven NAFLD and 93 healthy controls were recruited to a cohort representing the Chinese Han *** SAF(steatosis,activity,and fibrosis)scoring system was used for hepatic histopathological *** polymorphisms of ppargc1a rs8192678 and patatin-like phospholipase domain-containing protein 3(PNPLA3)rs738409 were *** intrahepatic mRNA expression of ppargc1a was evaluated by real-time polymerase chain *** Thirty-seven patients with NAFLD had NASH,of which 12 were *** ppargc1a rs8192678 risk A allele(carrying GA and AA genotypes)had the lowest P value in the dominant model;the odds ratio(OR)for NAFLD was 2.321[95%confidence interval(CI):1.121-4.806].After adjusting for age,sex,and the PNPLA3 rs738409 risk G allele,the ppargc1a rs8192678 A allele was a risk factor for NAFLD(OR 2.202,95%CI:1.030-4.705,P=0.042).The genetic analysis showed that patients with NAFLD,moderate-to-severe steatosis(S2-3),and Activity 2-4(A≥2)were more likely to carry A in ppargc1a rs8192678(OR 5.000,95%CI:1.343-18.620,P=0.012;and OR 4.071,95%CI:1.076-15.402,P=0.031).The multivariate logistic regression analysis showed that ppargc1a rs8192678 risk A allele was also independently associated with S2-3,A≥2,and NASH(OR 6.190,95%CI:1.508-25.410,P=0.011;OR 4.506,95%CI 1.070-18.978,P=0.040;and OR 6.337,95%CI:1.135-35.392,P=0.035,respectively)after adjusting for age,sex,body mass index,and PNPLA3 rs738409 risk G *** results also showed that this polymorphism was as

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis ppargc1a rs8192678 polymorphism Steatosis Activity

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