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Serotonin-2A receptor-activated pkctheta pathway in mediating longterm facilitation in rats with chronic intermittent hypoxia - the pre-Btzinger complex as a critical site for respiratory plasticity

Serotonin-2A receptor-activated PKCtheta pathway in mediatin...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yingying LIU,Jinping LIU,Xiaoyan WEI,Caiyun ZHAO,Haojun WANG,Jianhong DUAN,Sanjue HU,Gong JU Institute of Neurosciences,The Fourth Military Medical University,Xi''an,710032,China

＜正＞Respiratory behavior expresses diverse forms of plasticity by alterations in breathing *** of respiratory plasticity often leads to diseases,such as sudden infant death syndrome or obstructive sleep ***-term facilitation（LTF） is the most frequently studied model for respiratory *** intermittent hypoxia（AIH）,three to five short-term hypoxia episodes,induces phrenic LTF（pLTF）,whereas chronic intermittent hypoxia（CIH）,lasting for days or weeks’ stimulus episodes,evokes additional neuroplasticity and augmented *** previous studies,however,were mostly concentrated on phrenic neuroplasticity in high-cervical spinal *** pre-B（o|¨）tzinger complex（pre-B（o|¨）tC）,a critical kernel of respiratory rhythmogenesis in the ventrolateral medulla oblongata,has been obscure until *** established a CIH pLTF model through hypobaric hypoxia in adult *** goal was to determine whether the pre-B＆ouml;tC is required for ***-induced CIH rats generated the augmentation of the short-term hypoxic phrenic response and the enhanced pLTF.5-HT2A receptors in the pre-B（o|¨）tC were found localized to sites consistent with active internalization and externalization（re-sensitivity） in the CIH rats and not in ***-protein kinase C（PPKC） theta isoform and P-PKC substrates were highly expressed in the pre-B（o|¨）tC in CIH *** close association of P-pkctheta with the postsynaptic membrane was especially *** application of ketanserin,a 5-HT2A receptor specific antagonist,abolished pLTF in CIH rats,and pkctheta-pseudosubstrate,a pkctheta inhibitor,blocked pLTF in most CIH rats *** particular,a full abolishment of phrenic nerve activity was found in some CIH rats receiving both ketanserin and pkctheta-pseudosubstrate,indicating a strengthened effect of 5-HT2A receptor and pkctheta on *** on the neurochemical evidence of highly-activated 5-HT2A receptors and enhanced expressions of P-pkctheta and

关键词： long-term facilitation chronic intermittent hypoxia 5-HT2A receptor pkctheta pre-Btzinger complex rat

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