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XB130 inhibits healing of diabetic skin ulcers through the pi3k/akt signalling pathway

World Journal of Diabetes 2023年第9期14卷 1369-1384页

作者： Xin-Lin Zhu Dong-Ying Hu Zhao-Xiang Zeng Wei-Wei Jiang Tian-Yang Chen Tian-Cheng Chen Wan-Qing Liao Wen-Zhi Lei Wen-Jie Fang Wei-Hua Pan Department of Dermatology Shanghai Key Laboratory of Medical MycologyChangzheng HospitalNaval Medical UniversityShanghai 200003China Department of Vascular Surgery Department of Vascular SurgeryChanghai HospitalNavy Medical UniversityShanghai 20003China

BACkGROUND Diabetic skin ulcers,a significant global healthcare burden,are mainly caused by the inhibition of cell proliferation and impaired ***130 is an adaptor protein that regulates cell proliferation and ***,the role of XB130 in the development of diabetic skin ulcers remains *** To investigate whether XB130 can regulate the inhibition of proliferation and vascular damage induced by high ***,we aim to determine whether XB130 is involved in the healing process of diabetic skin ulcers,along with its molecular *** We conducted RNA-sequencing analysis to identify the key genes involved in diabetic skin *** investigated the effects of XB130 on wound healing using histological *** addition,we used reverse transcription-quantitative polymerase chain reaction,Western blot,terminal deoxynucleotidyl transferasemediated dUTP nick end labeling staining,immunofluorescence,wound healing,and tubule formation experiments to investigate their effects on cellular processes in human umbilical vein endothelial cells(HUVECs)stimulated with high ***,we performed functional analysis to elucidate the molecular mechanisms underlying diabetic skin *** RNA-sequencing analysis showed that the expression of XB130 was up-regulated in the tissues of diabetic skin *** of XB130 promoted the healing of skin wounds in mice,leading to an accelerated wound healing process and shortened wound healing *** the cellular level,knockdown of XB130 alleviated high glucose-induced inhibition of cell proliferation and angiogenic impairment in *** of the pi3k/akt pathway removed the proliferative effects and endothelial protection mediated by *** The findings of this study indicated that the expression of XB130 is up-regulated in high glucose-stimulated diabetic skin ulcers and *** of XB130 promotes cell proliferation and angiogenesis via the pi3k/akt

关键词： XB130 Diabetes mellitus Diabetic skin ulcers pi3k/akt signalling pathway

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